Aliases for NMRK1 Gene
External Ids for NMRK1 Gene
Previous HGNC Symbols for NMRK1 Gene
Previous GeneCards Identifiers for NMRK1 Gene
Nicotinamide adenine dinucleotide (NAD+) is essential for life in all organisms, both as a coenzyme for oxidoreductases and as a source of ADP-ribosyl groups used in various reactions. Nicotinic acid and nicotinamide, collectively known as niacin, are the vitamin precursors of NAD+. Nicotinamide riboside kinases, such as NRK1, function to synthesize NAD+ through nicotinamide mononucleotide using nicotinamide riboside as the precursor (Bieganowski and Brenner, 2004 [PubMed 15137942]).[supplied by OMIM, Mar 2008]
GeneCards Summary for NMRK1 Gene
NMRK1 (Nicotinamide Riboside Kinase 1) is a Protein Coding gene. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and NAD metabolism. Gene Ontology (GO) annotations related to this gene include kinase activity and ribosylnicotinamide kinase activity. An important paralog of this gene is NMRK2.
UniProtKB/Swiss-Prot Summary for NMRK1 Gene
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). The enzyme also phosphorylates the antitumor drugs tiazofurin and 3-deazaguanosine.