Aliases for NMRAL1 Gene
External Ids for NMRAL1 Gene
Previous GeneCards Identifiers for NMRAL1 Gene
This gene encodes an NADPH sensor protein that preferentially binds to NADPH. The encoded protein also negatively regulates the activity of NF-kappaB in a ubiquitylation-dependent manner. It plays a key role in cellular antiviral response by negatively regulating the interferon response factor 3-mediated expression of interferon beta. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
GeneCards Summary for NMRAL1 Gene
NMRAL1 (NmrA Like Redox Sensor 1) is a Protein Coding gene. Diseases associated with NMRAL1 include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1 and Kabuki Syndrome 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Metabolism. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity.
UniProtKB/Swiss-Prot Summary for NMRAL1 Gene
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.