Aliases for NMNAT2 Gene
Aliases for NMNAT2 Gene
- Nicotinamide Nucleotide Adenylyltransferase 2 2 3 5
- Nicotinamide Mononucleotide Adenylyltransferase 2 3 4
- Nicotinate-Nucleotide Adenylyltransferase 2 3 4
- NMN/NaMN Adenylyltransferase 2 3 4
- NaMN Adenylyltransferase 2 3 4
- NMN Adenylyltransferase 2 3 4
- C1orf15 3 4
- Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2 3
External Ids for NMNAT2 Gene
- HGNC: 16789
- Entrez Gene: 23057
- Ensembl: ENSG00000157064
- OMIM: 608701
- UniProtKB: Q9BZQ4
Previous HGNC Symbols for NMNAT2 Gene
- C1orf15
Previous GeneCards Identifiers for NMNAT2 Gene
- GC01M179737
- GC01M180456
- GC01M179951
- GC01M181483
- GC01M154453
Summaries for NMNAT2 Gene
-
This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for NMNAT2 Gene
NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2) is a Protein Coding gene. Diseases associated with NMNAT2 include Wallerian Degeneration. Among its related pathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. Gene Ontology (GO) annotations related to this gene include nicotinate-nucleotide adenylyltransferase activity and nicotinamide-nucleotide adenylyltransferase activity. An important paralog of this gene is NMNAT3.
UniProtKB/Swiss-Prot for NMNAT2 Gene
-
Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+).
Additional gene information for NMNAT2 Gene
- Monarch Initiative
- Search for NMNAT2 at DataMed
- Search for NMNAT2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMNAT2 Gene
Genomics for NMNAT2 Gene
GeneHancer (GH) Regulatory Elements for NMNAT2 Gene
Promoters and enhancers for NMNAT2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH01I183419 | Promoter/Enhancer | 1.3 | EPDnew ENCODE | 550.8 | +0.3 | 270 | 0.6 | ZNF76 SIN3A ZNF2 ZEB1 ZNF335 ZNF121 GLIS2 ZNF366 EGR2 SP3 | NMNAT2 SMG7 RPS3AP8 | |
| GH01I183303 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE dbSUPER | 550.1 | +114.3 | 114301 | 1.4 | PKNOX1 MNT FOS | NMNAT2 RPS3AP8 | |
| GH01I183416 | Enhancer | 0.9 | Ensembl | 559.9 | +1.3 | 1265 | 0.9 | SIN3A ZNF2 ZNF121 GLIS2 ZNF143 KLF7 YY2 MIER2 REST GLIS1 | NMNAT2 SMG7 RPS3AP8 | |
| GH01I183418 | Promoter | 0.6 | EPDnew | 550.8 | -0.1 | -75 | 0.1 | ZBTB17 | NMNAT2 LOC105371646 | |
| GH01I183317 | Enhancer | 1.1 | Ensembl ENCODE dbSUPER | 7.1 | +100.0 | 100035 | 1.3 | CTCF EBF1 CEBPG IRF4 RAD21 RELA ZNF664 GATA3 ZNF143 SMC3 | NMNAT2 RPS3AP8 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around NMNAT2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NMNAT2 gene promoter:
Regulatory Element Products
Genomic Locations for NMNAT2 Gene
Genomic Locations for NMNAT2 Gene
- chr1:183,248,237-183,418,602
- (GRCh38/hg38)
- Size:
- 170,366 bases
- Orientation:
- Minus strand
- chr1:183,217,372-183,387,737
- (GRCh37/hg19)
Genomic View for NMNAT2 Gene
Genes around NMNAT2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by Ensembl
- 1q25.3 by Entrez Gene
- 1q25.3 by HGNC
NMNAT2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NMNAT2 Gene
Proteins for NMNAT2 Gene
-
Protein details for NMNAT2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BZQ4-NMNA2_HUMAN
- Recommended name:
- Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2
- Protein Accession:
- Q9BZQ4
- O75067
- Q5T1Q3
- Q8WU99
- Q96QW1
Protein attributes for NMNAT2 Gene
- Size:
- 307 amino acids
- Molecular mass:
- 34439 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=BAA32324.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for NMNAT2 Gene
Post-translational modifications for NMNAT2 Gene
Other Protein References for NMNAT2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NMNAT2
-
Abcam antibodies for NMNAT2
- Invitrogen Antibodies for NMNAT2
- Search GeneTex for Antibodies for NMNAT2
-
Santa Cruz Biotechnology (SCBT) Antibodies for NMNAT2
Protein Products
- R&D Systems Proteins and Enzymes for NMNAT2 (NMNAT-2)
-
OriGene Purified Proteins for NMNAT2
- Search Origene for MassSpec and Protein Over-expression Lysates for NMNAT2
- Origene Custom Protein Services for NMNAT2
- Sino Biological Recombinant Proteins for NMNAT2
- Sino Biological Cell Lysates for NMNAT2
- ProSpec Recombinant Proteins for NMNAT2
- Search GeneTex for Proteins for NMNAT2
-
Abcam proteins for NMNAT2
Assay Products
No data available for DME Specific Peptides for NMNAT2 Gene
Domains & Families for NMNAT2 Gene
Gene Families for NMNAT2 Gene
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for NMNAT2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NMNAT2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BZQ4- Family:
-
- Belongs to the eukaryotic NMN adenylyltransferase family.
Function for NMNAT2 Gene
Molecular function for NMNAT2 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=32 uM for NMN {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=70 uM for NAD(+) {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=204 uM for ATP {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=1119 uM for PPi {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=14.5 uM for NaMN {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; KM=304 uM for NMNH {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=1.1 umol/min/mg enzyme for NAD synthesis {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=3 umol/min/mg enzyme for pyrophosphorolytic NAD(+) cleavage {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Vmax=7 umol/min/mg enzyme for pyrophosphorolytic NADH cleavage {ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747}; Note=KM is >100 uM for triazofurin monophosphate.; pH dependence: Optimum pH is 6.0-9.0. {ECO:0000269 PubMed:12359228, ECO:0000269 PubMed:16118205, ECO:0000269 PubMed:17402747};
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + nicotinamide ribonucleotide = diphosphate + NAD(+).
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD(+).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by P1-(adenosine-5)-P3-(nicotinamide-riboside-5)-triphosphate (Np3AD) and P1-(adenosine-5)-P4-(nicotinamide-riboside-5)-tetraphosphate (Np4AD).
- UniProtKB/Swiss-Prot Function:
- Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+).
Enzyme Numbers (IUBMB) for NMNAT2 Gene
Phenotypes From GWAS Catalog for NMNAT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity | TAS | -- |
| GO:0003824 | catalytic activity | IEA | -- |
| GO:0004515 | nicotinate-nucleotide adenylyltransferase activity | EXP,IDA | 16118205 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for NMNAT2 Gene
- MGI mutant phenotypes for NMNAT2:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for NMNAT2:
Animal Model Products
-
Taconic Biosciences Mouse Models for NMNAT2
- Cyagen custom Knockout/knockin (KOKI) mouse models for NMNAT2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for NMNAT2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NMNAT2 gene
- Search ViGene Biosciences for NMNAT2
CRISPR Products
-
OriGene CRISPR knockouts for NMNAT2
- genomics-online: gRNA clones - Search results for 109 available NMNAT2 gene related products
- Overview of 109 available NMNAT2 gene related products
- Applied Biological Materials CRISPR for NMNAT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NMNAT2
- GenScript: Design CRISPR guide RNA sequences for NMNAT2
miRNA for NMNAT2 Gene
- miRTarBase miRNAs that target NMNAT2
-
- hsa-mir-9-5p (MIRT021432)
- hsa-mir-122-5p (MIRT023309)
- hsa-let-7c (MIRT038995)
- hsa-mir-615-3p (MIRT040033)
- hsa-mir-6867-5p (MIRT608050)
- hsa-mir-574-5p (MIRT608051)
- hsa-mir-5089-3p (MIRT609015)
- hsa-mir-592 (MIRT620698)
- hsa-mir-597-5p (MIRT620699)
- hsa-mir-223-3p (MIRT620700)
- hsa-mir-4697-3p (MIRT620701)
- hsa-mir-4328 (MIRT620702)
- hsa-mir-1304-5p (MIRT626547)
- hsa-mir-6858-5p (MIRT626548)
- hsa-mir-4689 (MIRT626549)
- hsa-mir-1224-5p (MIRT626550)
- hsa-mir-3915 (MIRT626551)
- hsa-mir-4455 (MIRT635696)
- hsa-mir-5572 (MIRT635697)
- hsa-mir-4260 (MIRT635698)
- hsa-mir-450a-2-3p (MIRT635699)
- hsa-mir-6803-5p (MIRT635700)
- hsa-mir-6751-5p (MIRT635701)
- hsa-mir-7109-5p (MIRT635702)
- hsa-mir-4665-5p (MIRT635703)
- hsa-mir-1275 (MIRT635704)
- hsa-mir-6740-5p (MIRT635705)
- hsa-mir-6885-5p (MIRT635706)
- hsa-mir-328-5p (MIRT635707)
- hsa-mir-6887-5p (MIRT635708)
- hsa-mir-6795-5p (MIRT635709)
- hsa-mir-1255a (MIRT783225)
- hsa-mir-1255b-5p (MIRT783228)
- hsa-mir-342-5p (MIRT784901)
- hsa-mir-3960 (MIRT785482)
- hsa-mir-4278 (MIRT785570)
- hsa-mir-4466 (MIRT785953)
- hsa-mir-4664-5p (MIRT786349)
- hsa-mir-4716-3p (MIRT786513)
- hsa-mir-6716-5p (MIRT788452)
- hsa-mir-6717-5p (MIRT788453)
- hsa-mir-6732-5p (MIRT788488)
- hsa-mir-6744-5p (MIRT788534)
- hsa-mir-6752-5p (MIRT788564)
- hsa-mir-675-5p (MIRT788575)
- hsa-mir-6794-5p (MIRT788791)
- hsa-mir-6805-5p (MIRT788855)
- hsa-mir-6835-5p (MIRT789023)
- hsa-mir-6842-5p (MIRT789046)
- hsa-mir-7110-5p (MIRT789415)
- hsa-mir-8072 (MIRT789804)
miRNA Products
- Search ViGene Biosciences for NMNAT2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for NMNAT2
- Browse OriGene Inhibitory RNA Products For NMNAT2
- genomics-online: shRNA clones - Search results for 109 available NMNAT2 gene related products
- Overview of 109 available NMNAT2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NMNAT2 gene
Clone Products
- Sino Biological Human cDNA Clone for NMNAT2
- VectorBuilder custom plasmid, inducible vectors for NMNAT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NMNAT2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NMNAT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NMNAT2
-
ViGene Biosciences adenoviral particle packaged cDNA for NMNAT2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for NMNAT2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for NMNAT2 gene
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMNAT2 Gene
Localization for NMNAT2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for NMNAT2 Gene
- Cytoplasm. Golgi apparatus.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| mitochondrion | 2 |
| cytosol | 2 |
| endosome | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005770 | late endosome | IEA | -- |
| GO:0005794 | Golgi apparatus | IEA,IDA | 16118205 |
| GO:0005802 | trans-Golgi network | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NMNAT2 Gene
Pathways & Interactions for NMNAT2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | NAD metabolism |
.42
|
.01
|
| 2 | Metabolism |
.37
|
|
| 3 | Metabolism of water-soluble vitamins and cofactors | ||
Pathways by source for NMNAT2 Gene
1 BioSystems pathway for NMNAT2 Gene
4 Reactome pathways for NMNAT2 Gene
2 KEGG pathways for NMNAT2 Gene
1 GeneGo (Thomson Reuters) pathway for NMNAT2 Gene
UniProtKB/Swiss-Prot Q9BZQ4-NMNA2_HUMAN
- Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.
- Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
Interacting Proteins for NMNAT2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0009058 | biosynthetic process | IEA | -- |
| GO:0009435 | NAD biosynthetic process | IEA,IC | 16118205 |
| GO:0019363 | pyridine nucleotide biosynthetic process | IEA | -- |
| GO:0019674 | NAD metabolic process | TAS | -- |
| GO:0034628 | de novo NAD biosynthetic process from aspartate | IBA | -- |
No data available for SIGNOR curated interactions for NMNAT2 Gene
Drugs & Compounds for NMNAT2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| beta-nicotinamide D-ribonucleotide |
|
|
||||
| Nicotinamide ribotide |
|
1094-61-7 |
|
|||
| nicotinate beta-D-ribonucleotide |
|
|
|
|||
| Nicotinic acid adenine dinucleotide |
|
6450-77-7 |
|
|||
| Nicotinic acid mononucleotide |
|
321-02-8 |
|
Transcripts for NMNAT2 Gene
mRNA/cDNA for NMNAT2 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (71) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for NMNAT2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for NMNAT2
- genomics-online: gRNA clones - Search results for 109 available NMNAT2 gene related products
- Overview of 109 available NMNAT2 gene related products
- Applied Biological Materials CRISPR for NMNAT2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NMNAT2
- GenScript: Design CRISPR guide RNA sequences for NMNAT2
miRNA Products
- Search ViGene Biosciences for NMNAT2
Inhibitory RNA Products
- Origene RNAi, shrna, and sirna products in human, mouse, rat for NMNAT2
- Browse OriGene Inhibitory RNA Products For NMNAT2
- genomics-online: shRNA clones - Search results for 109 available NMNAT2 gene related products
- Overview of 109 available NMNAT2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for NMNAT2 gene
Clone Products
- Sino Biological Human cDNA Clone for NMNAT2
- VectorBuilder custom plasmid, inducible vectors for NMNAT2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NMNAT2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for NMNAT2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for NMNAT2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
- Gut Tube (Gastrointestinal Tract)
mRNA differential expression in normal tissues according to GTEx for NMNAT2 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x7.1), Brain - Cerebellum (x5.6), Brain - Frontal Cortex (BA9) (x5.5), Brain - Cortex (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.4).
This gene is overexpressed in Hair follicle (68.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMNAT2 Gene
NURSA nuclear receptor signaling pathways regulating expression of NMNAT2 Gene:
NMNAT2SOURCE GeneReport for Unigene cluster for NMNAT2 Gene:
Hs.497123mRNA Expression by UniProt/SwissProt for NMNAT2 Gene:
Q9BZQ4-NMNA2_HUMAN
Tissue specificity:
Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.
Evidence on tissue expression from TISSUES for NMNAT2 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for NMNAT2
-
OriGene qPCR primer pairs and template standards for NMNAT2
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NMNAT2 Gene
Orthologs for NMNAT2 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NMNAT2 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | NMNAT2 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | NMNAT2 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NMNAT2 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | NMNAT2 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Nmnat2 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nmnat2 33 16 34 |
|
||
| chicken (Gallus gallus) |
Aves | NMNAT2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | NMNAT2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nmnat2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | nmnat2 33 34 |
|
||
| -- 33 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | nmat-1 34 |
|
OneToMany | |
| nmat-2 34 |
|
OneToMany | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | NMA2 34 |
|
ManyToMany | |
| NMA1 34 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for NMNAT2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for NMNAT2 Gene
Variants for NMNAT2 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005326 | -- | 183,340,349(-) | T/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000036265 | -- | 183,296,207(-) | T/C | intron_variant | |
| rs1000065548 | -- | 183,352,879(-) | G/A | genic_upstream_transcript_variant, intron_variant | |
| rs1000087266 | -- | 183,392,183(-) | G/C | genic_upstream_transcript_variant, intron_variant | |
| rs1000106590 | -- | 183,388,704(-) | T/A | genic_upstream_transcript_variant, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660635 | CNV | deletion | 23128226 |
| esv2720117 | CNV | deletion | 23290073 |
| esv2720128 | CNV | deletion | 23290073 |
| esv3588109 | CNV | loss | 21293372 |
| esv3588110 | CNV | gain | 21293372 |
| esv3588111 | CNV | loss | 21293372 |
| esv3588112 | CNV | loss | 21293372 |
| nsv1122429 | CNV | deletion | 24896259 |
| nsv946538 | CNV | duplication | 23825009 |
| nsv999841 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.67;
82.89% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NMNAT2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMNAT2 Gene
Disorders for NMNAT2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| wallerian degeneration |
|
|
Search NMNAT2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for NMNAT2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for NMNAT2 Gene
Publications for NMNAT2 Gene
- Characterization of human brain nicotinamide 5'-mononucleotide adenylyltransferase-2 and expression in human pancreas. (PMID: 14516279) Yalowitz JA … Jayaram HN (The Biochemical journal 2004) 3 4 22 58
- Identification of a novel human nicotinamide mononucleotide adenylyltransferase. (PMID: 12359228) Raffaelli N … Magni G (Biochemical and biophysical research communications 2002) 2 3 4 58
- Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R … Carpten JD (Genomics 2001) 2 3 4 58
- A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. (PMID: 20962850) Budarf ML … Rioux JD (Genes and immunity 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for NMNAT2 Gene
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- Cloud-Clone Corp. primary cells service
- Taconic Biosciences Mouse Models for NMNAT2
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 34 available NMNAT2 Antibodies ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for NMNAT2 gene
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- genomics-online: cdna clones - Search results for 109 available NMNAT2 gene related products
- Overview of 109 available NMNAT2 gene related products
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- Overview of 109 available NMNAT2 gene related products
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- Overview of 109 available NMNAT2 gene related products
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- Overview of 109 available NMNAT2 gene related products
- genomics-online: shRNA clones - Search results for 109 available NMNAT2 gene related products
- Overview of 109 available NMNAT2 gene related products
Sources for NMNAT2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
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- (18) KEGG
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- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (114) diseasecard
- (115) NIH Rare Diseases
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- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
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- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
