Free for academic non-profit institutions. Other users need a Commercial license
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
NMI (N-Myc And STAT Interactor) is a Protein Coding gene. Among its related pathways are IL-2 Signaling Pathway and Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity. An important paralog of this gene is IFI35.
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH02J151288 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas | 635.6 | +0.4 | 350 | 3.9 | HNRNPL GATAD2A IKZF1 ZNF692 POLR2A JUND FOXA1 LARP7 PRDM1 MTA2 | NMI RBM43 lnc-RBM43-3 TNFAIP6 RIF1 STAM2 RPL30P2 | |
GH02J151339 | Promoter/Enhancer | 0.7 | EPDnew ENCODE | 600.3 | -49.6 | -49646 | 0.8 | IKZF1 ZSCAN4 POLR2A | NMI TNFAIP6 piR-48950-096 LOC101929319 | |
GH02J151337 | Promoter | 0.5 | EPDnew | 600.3 | -47.7 | -47736 | 0.1 | MAFK CEBPG | NMI TNFAIP6 piR-48950-096 | |
GH02J151303 | Enhancer | 1 | FANTOM5 Ensembl | 31 | -13.1 | -13107 | 0.8 | JUND DDX20 ZIC2 PKNOX1 HDAC1 SOX6 EP300 KLF9 TCF7L2 CEBPB | TNFAIP6 NMI RBM43 HSALNG0019608 piR-39098-116 | |
GH02J151297 | Enhancer | 0.9 | Ensembl ENCODE | 30.8 | -7.6 | -7607 | 3.4 | ZNF512 IKZF2 POLR2A YY1 DPF2 RELB CTBP1 MCM3 FOSL1 EHMT2 | piR-39098-116 TNFAIP6 NMI STAM2 RPL30P2 RBM43 HSALNG0019608 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003712 | transcription coregulator activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 9989503 |
GO:0042802 | identical protein binding | IPI | 21516116 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | TAS,IDA | 10597290 |
GO:0005829 | cytosol | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | IL-2 Pathway |
Prolactin Signaling
.54
|
|
2 | Prolactin Signaling Pathway |
Development Prolactin receptor signaling
.38
|
|
3 | IL-2 Signaling Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006366 | transcription by RNA polymerase II | TAS,IEA | -- |
GO:0006954 | inflammatory response | TAS | 9989503 |
GO:0007259 | JAK-STAT cascade | TAS | 10597290 |
GO:0032480 | negative regulation of type I interferon production | IEA | -- |
GO:0045355 | negative regulation of interferon-alpha biosynthetic process | IEA | -- |
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||
SP2: | |||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||
SP4: | - | ||||||||||||||||||||||
SP5: | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NMI 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NMI 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NMI 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nmi 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nmi 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | NMI 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NMI 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NMI 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nmi 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC792676 30 |
|
||
NMI 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs150664393 | Not Provided: not provided | 151,270,705(-) | G/T | NONSENSE | |
rs1048135 | - | p.Ser16Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4094n100 | CNV | gain | 25217958 |
dgv744e214 | CNV | loss | 21293372 |
esv34659 | CNV | loss | 17911159 |
nsv1012891 | CNV | gain | 25217958 |
nsv523849 | CNV | gain | 19592680 |
nsv834417 | CNV | gain | 17160897 |
No disorders were found for NMI Gene.