NMI Gene (Protein Coding)

N-Myc And STAT Interactor

GC02M151270
GIFtS:
38
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all h... See more...

Aliases for NMI Gene

Aliases for NMI Gene

  • N-Myc And STAT Interactor 2 3 4 5
  • N-Myc-Interactor 3 4
  • N-Myc (And STAT) Interactor 2
  • NMI 5
  • Nmi 4

External Ids for NMI Gene

Previous GeneCards Identifiers for NMI Gene

  • GC02M149820
  • GC02M150656
  • GC02M152091
  • GC02M152329
  • GC02M151952
  • GC02M151835
  • GC02M152126
  • GC02M144023

Summaries for NMI Gene

Entrez Gene Summary for NMI Gene

  • NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]

GeneCards Summary for NMI Gene

NMI (N-Myc And STAT Interactor) is a Protein Coding gene. Among its related pathways are IL-2 Signaling Pathway and Prolactin Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity. An important paralog of this gene is IFI35.

UniProtKB/Swiss-Prot Summary for NMI Gene

  • May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.

Gene Wiki entry for NMI Gene

Additional gene information for NMI Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NMI Gene

Genomics for NMI Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NMI Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J151288 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 635.6 +0.4 350 3.9 HNRNPL GATAD2A IKZF1 ZNF692 POLR2A JUND FOXA1 LARP7 PRDM1 MTA2 NMI RBM43 lnc-RBM43-3 TNFAIP6 RIF1 STAM2 RPL30P2
GH02J151339 Promoter/Enhancer 0.7 EPDnew ENCODE 600.3 -49.6 -49646 0.8 IKZF1 ZSCAN4 POLR2A NMI TNFAIP6 piR-48950-096 LOC101929319
GH02J151337 Promoter 0.5 EPDnew 600.3 -47.7 -47736 0.1 MAFK CEBPG NMI TNFAIP6 piR-48950-096
GH02J151303 Enhancer 1 FANTOM5 Ensembl 31 -13.1 -13107 0.8 JUND DDX20 ZIC2 PKNOX1 HDAC1 SOX6 EP300 KLF9 TCF7L2 CEBPB TNFAIP6 NMI RBM43 HSALNG0019608 piR-39098-116
GH02J151297 Enhancer 0.9 Ensembl ENCODE 30.8 -7.6 -7607 3.4 ZNF512 IKZF2 POLR2A YY1 DPF2 RELB CTBP1 MCM3 FOSL1 EHMT2 piR-39098-116 TNFAIP6 NMI STAM2 RPL30P2 RBM43 HSALNG0019608
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMI on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NMI

Top Transcription factor binding sites by QIAGEN in the NMI gene promoter:
  • Bach1
  • C/EBPbeta
  • Evi-1
  • GATA-3
  • GR
  • GR-alpha
  • GR-beta
  • SRF
  • SRF (504 AA)
  • STAT3

Genomic Locations for NMI Gene

Genomic Locations for NMI Gene
chr2:151,270,465-151,289,894
(GRCh38/hg38)
Size:
19,430 bases
Orientation:
Minus strand
chr2:152,126,979-152,146,571
(GRCh37/hg19)
Size:
19,593 bases
Orientation:
Minus strand

Genomic View for NMI Gene

Genes around NMI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMI Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NMI Gene

Proteins for NMI Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NMI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13287-NMI_HUMAN
    Recommended name:
    N-myc-interactor
    Protein Accession:
    Q13287
    Secondary Accessions:
    • B5BU69
    • Q53TI8
    • Q8WTW2
    • Q9BVE5

    Protein attributes for NMI Gene

    Size:
    307 amino acids
    Molecular mass:
    35057 Da
    Quaternary structure:
    • Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.

neXtProt entry for NMI Gene

Protein Expression for NMI Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NMI Gene

  • Ubiquitination at Lys70, Lys95, Lys102, Lys111, Lys129, Lys183, Lys245, Lys284, and Lys294
  • Modification sites at PhosphoSitePlus

Other Protein References for NMI Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NMI Gene

Domains & Families for NMI Gene

Gene Families for NMI Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NMI Gene

InterPro:
Blocks:
  • Nmi/IFP 35
ProtoNet:

Suggested Antigen Peptide Sequences for NMI Gene

GenScript: Design optimal peptide antigens:
  • N-myc and STAT interactor (NMI_HUMAN)
  • N-myc (And STAT) interactor (Q8WTW2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13287

UniProtKB/Swiss-Prot:

NMI_HUMAN :
  • Belongs to the NMI family.
Family:
  • Belongs to the NMI family.
genes like me logo Genes that share domains with NMI: view

Function for NMI Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NMI Gene

UniProtKB/Swiss-Prot Function:
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.
UniProtKB/Swiss-Prot Induction:
By IL2/interleukin-2 and IFNG/IFN-gamma.
GENATLAS Biochemistry:
N-myc interactor,also interacting with c-myc,Max and STATs (except STAT2) transcription factors carrying leucine zipper with/without helix-loop-helix,expressed at low levels in all fetal and adult tissues,except brain,increasing STA mediated transcription in response to IL2 and IFNG

Phenotypes From GWAS Catalog for NMI Gene

Gene Ontology (GO) - Molecular Function for NMI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription coregulator activity TAS,IEA --
GO:0005515 protein binding IPI 9989503
GO:0042802 identical protein binding IPI 21516116
genes like me logo Genes that share ontologies with NMI: view
genes like me logo Genes that share phenotypes with NMI: view

Animal Model Products

CRISPR Products

miRNA for NMI Gene

miRTarBase miRNAs that target NMI

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMI

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMI Gene

Localization for NMI Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMI Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMI gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS,IDA 10597290
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NMI: view

Pathways & Interactions for NMI Gene

PathCards logo

SuperPathways for NMI Gene

SuperPathway Contained pathways
1 IL-2 Pathway
Prolactin Signaling
.54
2 Prolactin Signaling Pathway
Development Prolactin receptor signaling
.38
3 IL-2 Signaling Pathway
IL-2 Signaling Pathway
.49
genes like me logo Genes that share pathways with NMI: view

Pathways by source for NMI Gene

1 BioSystems pathway for NMI Gene
1 GeneGo (Thomson Reuters) pathway for NMI Gene
  • Development Prolactin receptor signaling
1 Qiagen pathway for NMI Gene
  • Prolactin Signaling

SIGNOR curated interactions for NMI Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for NMI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS,IEA --
GO:0006954 inflammatory response TAS 9989503
GO:0007259 JAK-STAT cascade TAS 10597290
GO:0032480 negative regulation of type I interferon production IEA --
GO:0045355 negative regulation of interferon-alpha biosynthetic process IEA --
genes like me logo Genes that share ontologies with NMI: view

Drugs & Compounds for NMI Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for NMI Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NMI Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMI

Alternative Splicing Database (ASD) splice patterns (SP) for NMI Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9
SP1: - - -
SP2:
SP3: - - -
SP4: -
SP5: -

Relevant External Links for NMI Gene

GeneLoc Exon Structure for
NMI

Expression for NMI Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMI Gene

mRNA expression in normal human tissues for NMI Gene
mRNA expression by GTEx for NMI GenemRNA expression by BioGPS for NMI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMI Gene

This gene is overexpressed in Whole Blood (x10.1).

Protein differential expression in normal tissues from HIPED for NMI Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.7), Lymph node (10.3), and Monocytes (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NMI Gene



Protein tissue co-expression partners for NMI Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NMI

SOURCE GeneReport for Unigene cluster for NMI Gene:

Hs.54483

mRNA Expression by UniProt/SwissProt for NMI Gene:

Q13287-NMI_HUMAN
Tissue specificity: Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.

Evidence on tissue expression from TISSUES for NMI Gene

  • Bone marrow(4.3)
  • Blood(2.4)
  • Spleen(2.1)
genes like me logo Genes that share expression patterns with NMI: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NMI Gene

Orthologs for NMI Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMI Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NMI 30 31
  • 99.67 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NMI 30 31
  • 82.3 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NMI 30 31
  • 79.48 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Nmi 30
  • 73.75 (n)
Mouse
(Mus musculus)
 Mammalia Nmi 30 17 31
  • 73.72 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 58 (a)
 OneToMany
-- 31
  • 54 (a)
 OneToMany
-- 31
  • 50 (a)
 OneToMany
-- 31
  • 50 (a)
 OneToMany
Oppossum
(Monodelphis domestica)
 Mammalia NMI 31
  • 55 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NMI 30 31
  • 57.09 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NMI 31
  • 40 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nmi 30
  • 51.19 (n)
Zebrafish
(Danio rerio)
 Actinopterygii LOC792676 30
  • 47.22 (n)
NMI 31
  • 24 (a)
 OneToOne
Species where no ortholog for NMI was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NMI Gene

ENSEMBL:
Gene Tree for NMI (if available)
TreeFam:
Gene Tree for NMI (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMI: view image

Paralogs for NMI Gene

Paralogs for NMI Gene

genes like me logo Genes that share paralogs with NMI: view

Variants for NMI Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NMI Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs150664393 Not Provided: not provided 151,270,705(-) G/T NONSENSE
rs1048135 - p.Ser16Leu

Additional dbSNP identifiers (rs#s) for NMI Gene

Structural Variations from Database of Genomic Variants (DGV) for NMI Gene

Variant ID Type Subtype PubMed ID
dgv4094n100 CNV gain 25217958
dgv744e214 CNV loss 21293372
esv34659 CNV loss 17911159
nsv1012891 CNV gain 25217958
nsv523849 CNV gain 19592680
nsv834417 CNV gain 17160897

Variation tolerance for NMI Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMI Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMI

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMI Gene

Disorders for NMI Gene

Additional Disease Information for NMI

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for NMI Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMI Gene

Publications for NMI Gene

  1. Isolation and characterization of Nmi, a novel partner of Myc proteins. (PMID: 8668343) Bao J … Zervos AS (Oncogene 1996) 2 3 4 23
  2. Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. (PMID: 9989503) Zhu M … Leonard WJ (Cell 1999) 2 3 4
  3. Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth. (PMID: 19358268) Fillmore RA … Samant RS (International journal of cancer 2009) 3 23
  4. Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer. (PMID: 19240718) Quaye L … Gayther SA (British journal of cancer 2009) 3 41
  5. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 41

ExternalLinks

View latest publications for NMI gene in Mastermind

Products for NMI Gene

Sources for NMI Gene