Aliases for NMI Gene
Aliases for NMI Gene
External Ids for NMI Gene
- HGNC: 7854
- Entrez Gene: 9111
- Ensembl: ENSG00000123609
- OMIM: 603525
- UniProtKB: Q13287
Previous GeneCards Identifiers for NMI Gene
- GC02M149820
- GC02M150656
- GC02M152091
- GC02M152329
- GC02M151952
- GC02M151835
- GC02M152126
- GC02M144023
Summaries for NMI Gene
-
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
GeneCards Summary for NMI Gene
NMI (N-Myc And STAT Interactor) is a Protein Coding gene. Among its related pathways are IL-2 Pathway and IL-2 Signaling Pathway. Gene Ontology (GO) annotations related to this gene include transcription coregulator activity. An important paralog of this gene is IFI35.
UniProtKB/Swiss-Prot for NMI Gene
-
May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMI Gene
Genomics for NMI Gene
GeneHancer (GH) Regulatory Elements for NMI Gene
Promoters and enhancers for NMI Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH02J151287 | Promoter/Enhancer | 2.3 | EPDnew FANTOM5 Ensembl ENCODE | 685.7 | +0.3 | 335 | 3.5 | PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B CBX5 ZNF207 FOS | NMI RBM43 TNFAIP6 RIF1 STAM2 RPL30P2 | |
| GH02J151339 | Promoter/Enhancer | 1.1 | EPDnew Ensembl ENCODE | 650.2 | -49.5 | -49483 | 0.8 | POLR2A IKZF1 ZSCAN4 | NMI TNFAIP6 LOC101929319 | |
| GH02J151337 | Promoter | 0.7 | EPDnew | 650.2 | -47.6 | -47573 | 0.1 | CEBPG MAFK | NMI TNFAIP6 | |
| GH02J151297 | Enhancer | 0.9 | Ensembl ENCODE | 29 | -8.0 | -7990 | 1.3 | JUN BATF IRF4 FOSL1 CTBP1 POLR2A NFATC1 ATF7 ETV6 IKZF2 | TNFAIP6 NMI STAM2 RPL30P2 RBM43 | |
| GH02J151260 | Promoter/Enhancer | 2 | EPDnew Ensembl ENCODE | 5.2 | +28.8 | 28754 | 2.5 | ARNT SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143 MXD4 REST | RBM43 TNFAIP6 NMI ENSG00000236885 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around NMI on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the NMI gene promoter:
-
- STAT3
- C/EBPbeta
- Evi-1
- GR-beta
- GR-alpha
- GR
- SRF (504 AA)
- SRF
- GATA-3
- Bach1
Regulatory Element Products
Genomic Locations for NMI Gene
Genomic Locations for NMI Gene
- chr2:151,270,465-151,290,057
- (GRCh38/hg38)
- Size:
- 19,593 bases
- Orientation:
- Minus strand
- chr2:152,126,979-152,146,571
- (GRCh37/hg19)
- Size:
- 19,593 bases
- Orientation:
- Minus strand
Genomic View for NMI Gene
Genes around NMI on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q23.3 by Entrez Gene
- 2q23.3 by HGNC
- 2q23.3 by Ensembl
NMI Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NMI Gene
Proteins for NMI Gene
-
Protein details for NMI Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q13287-NMI_HUMAN
- Recommended name:
- N-myc-interactor
- Protein Accession:
- Q13287
- B5BU69
- Q53TI8
- Q8WTW2
- Q9BVE5
Protein attributes for NMI Gene
- Size:
- 307 amino acids
- Molecular mass:
- 35057 Da
- Quaternary structure:
-
- Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif. Interacts with all STAT proteins except STAT2.
Protein Expression for NMI Gene
Post-translational modifications for NMI Gene
Other Protein References for NMI Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for NMI
-
Abcam antibodies for NMI
- Invitrogen Antibodies for NMI
- GeneTex NMI Antibody for NMI
-
Santa Cruz Biotechnology (SCBT) Antibodies for NMI
Protein Products
-
OriGene Purified Proteins for NMI
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- ProSpec Recombinant Proteins for NMI
- Search GeneTex for Proteins for NMI
-
Abcam proteins for NMI
Assay Products
- antibodies-online: Search results for 5 available NMI Elisa Kits ranked by validation data
- Compare Top NMI Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for NMI Gene
Domains & Families for NMI Gene
Gene Families for NMI Gene
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for NMI Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for NMI Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q13287- Family:
-
- Belongs to the NMI family.
Function for NMI Gene
Molecular function for NMI Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5.
- UniProtKB/Swiss-Prot Induction:
- By IL2/interleukin-2 and IFNG/IFN-gamma.
- GENATLAS Biochemistry:
- N-myc interactor,also interacting with c-myc,Max and STATs (except STAT2) transcription factors carrying leucine zipper with/without helix-loop-helix,expressed at low levels in all fetal and adult tissues,except brain,increasing STA mediated transcription in response to IL2 and IFNG
Phenotypes From GWAS Catalog for NMI Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003712 | transcription coregulator activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 9989503 |
| GO:0042802 | identical protein binding | IPI | 21516116 |
Phenotypes for NMI Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for NMI
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- Overview of 133 available NMI gene related products
- Applied Biological Materials CRISPR for NMI
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NMI
- GenScript: Design CRISPR guide RNA sequences for NMI
miRNA for NMI Gene
- miRTarBase miRNAs that target NMI
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NMI
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- Overview of 133 available NMI gene related products
Clone Products
- Sino Biological Human cDNA Clone for NMI
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NMI
- Applied Biological Materials Clones for NMI
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for NMI
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMI Gene
Localization for NMI Gene
Subcellular locations from UniProtKB/Swiss-Prot for NMI Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 1 |
- Cytosol (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,TAS | 10597290 |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for NMI Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-2 Pathway | ||
| 2 | Prolactin Signaling Pathway | ||
| 3 | IL-2 Signaling Pathway | ||
Pathways by source for NMI Gene
1 BioSystems pathway for NMI Gene
1 GeneGo (Thomson Reuters) pathway for NMI Gene
1 Qiagen pathway for NMI Gene
Interacting Proteins for NMI Gene
Selected Interacting proteins:
Q13287-NMI_HUMAN
ENSP00000243346
for NMI Gene via
UniProtKB
STRING
MINT
IID
GPS-Prot Interaction Network for NMI
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006366 | transcription by RNA polymerase II | TAS,IEA | -- |
| GO:0006954 | inflammatory response | TAS | 9989503 |
| GO:0007259 | JAK-STAT cascade | TAS | 10597290 |
| GO:0032480 | negative regulation of type I interferon production | IEA | -- |
| GO:0045355 | negative regulation of interferon-alpha biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for NMI Gene
Transcripts for NMI Gene
mRNA/cDNA for NMI Gene
- (3) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (136) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000243346 1623 bps (uc002txi.3)
- ENST00000491771 2094 bps (uc061ooy.1)
- ENST00000414946 581 bps (uc061ooz.1)
- ENST00000477072 455 bps (uc061opa.1)
Unigene Clusters for NMI Gene
CRISPR Products
-
OriGene CRISPR knockouts for NMI
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NMI
- genomics-online: gRNA clones - Search results for 133 available NMI gene related products
- Overview of 133 available NMI gene related products
- Applied Biological Materials CRISPR for NMI
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for NMI
- GenScript: Design CRISPR guide RNA sequences for NMI
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for NMI
- Browse OriGene Inhibitory RNA Products For NMI
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMI
- genomics-online: shRNA clones - Search results for 133 available NMI gene related products
- Overview of 133 available NMI gene related products
Clone Products
- Sino Biological Human cDNA Clone for NMI
- VectorBuilder custom plasmid, inducible vectors for NMI
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for NMI
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NMI
- Applied Biological Materials Clones for NMI
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||
| SP5: | - |
Expression for NMI Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
mRNA differential expression in normal tissues according to GTEx for NMI Gene
This gene is overexpressed in Whole Blood (x10.1).
This gene is overexpressed in Peripheral blood mononuclear cells (17.7), Lymph node (10.3), and Monocytes (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NMI Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of NMI Gene:
NMISOURCE GeneReport for Unigene cluster for NMI Gene:
Hs.54483mRNA Expression by UniProt/SwissProt for NMI Gene:
Q13287-NMI_HUMAN
Tissue specificity:
Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissues especially liver.
Evidence on tissue expression from TISSUES for NMI Gene
- Bone marrow(4.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for NMI
-
OriGene qPCR primer pairs for NMI
- genomics-online: primer clones - Search results for 133 available NMI gene related products
- Overview of 133 available NMI gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NMI Gene
Orthologs for NMI Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | NMI 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | NMI 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | NMI 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Nmi 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Nmi 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| -- 34 |
|
OneToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | NMI 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | NMI 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | NMI 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | nmi 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC792676 33 |
|
||
| NMI 34 |
|
OneToOne |
- Species where no ortholog for NMI was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for NMI Gene
- ENSEMBL:
- Gene Tree for NMI (if available)
- TreeFam:
- Gene Tree for NMI (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NMI: view image
Paralogs for NMI Gene
Variants for NMI Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000056449 | -- | 151,284,286(-) | A/T | intron_variant | |
| rs1000073841 | -- | 151,283,179(-) | C/T | intron_variant | |
| rs1000425291 | -- | 151,283,423(-) | G/T | intron_variant | |
| rs1000565159 | -- | 151,278,198(-) | A/G | intron_variant | |
| rs1000584114 | -- | 151,272,031(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv4094n100 | CNV | gain | 25217958 |
| dgv744e214 | CNV | loss | 21293372 |
| esv34659 | CNV | loss | 17911159 |
| nsv1012891 | CNV | gain | 25217958 |
| nsv523849 | CNV | gain | 19592680 |
| nsv834417 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.04;
21.33% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NMI Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NMI
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMI Gene
Disorders for NMI Gene
Additional Disease Information for NMI
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for NMI Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NMI Gene
Publications for NMI Gene
- Isolation and characterization of Nmi, a novel partner of Myc proteins. (PMID: 8668343) Bao J … Zervos AS (Oncogene 1996) 2 3 4 22 58
- Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. (PMID: 9989503) Zhu M … Leonard WJ (Cell 1999) 2 3 4 58
- Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. (PMID: 18950845) Vega A … Carracedo A (Gynecologic oncology 2009) 3 44 58
- Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth. (PMID: 19358268) Fillmore RA … Samant RS (International journal of cancer 2009) 3 22 58
- Tagging single-nucleotide polymorphisms in candidate oncogenes and susceptibility to ovarian cancer. (PMID: 19240718) Quaye L … Gayther SA (British journal of cancer 2009) 3 44 58
Products for NMI Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 52 available NMI Antibodies ranked by validation data
- Compare Top NMI Antibodies
- antibodies-online: Search results for 5 available NMI Elisa Kits ranked by validation data
- Compare Top NMI Elisa Kits
- Quality Products:
- antibodies-online: Search results for 10 available NMI Proteins ranked by validation data
- Compare Top NMI Proteins
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- GeneTex NMI Antibody for NMI
- Search GeneTex for Proteins for NMI
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- Horizon Cell Lines for NMI
- genomics-online: cdna clones - Search results for 133 available NMI gene related products
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- Overview of 133 available NMI gene related products
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Sources for NMI Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
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