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Aliases for NME9 Gene

Aliases for NME9 Gene

  • NME/NM23 Family Member 9 2 3 5
  • Thioredoxin-Like Protein 2 3 4
  • NME Gene Family Member 9 2 3
  • TXNDC6 3 4
  • TXL-2 3 4
  • TXL2 3 4
  • Thioredoxin Domain-Containing Protein 6 3
  • Thioredoxin Domain Containing 6 2
  • NME Family Member 9 2
  • NM23-H9 3

External Ids for NME9 Gene

Previous HGNC Symbols for NME9 Gene

  • TXNDC6

Previous GeneCards Identifiers for NME9 Gene

  • GC03M137981

Summaries for NME9 Gene

GeneCards Summary for NME9 Gene

NME9 (NME/NM23 Family Member 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.

UniProtKB/Swiss-Prot for NME9 Gene

  • May be a regulator of microtubule physiology.

Additional gene information for NME9 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME9 Gene

Genomics for NME9 Gene

GeneHancer (GH) Regulatory Elements for NME9 Gene

Promoters and enhancers for NME9 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I138326 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +1.8 1822 4.4 HDGF ELF3 PKNOX1 FOXA2 ARID4B SIN3A BMI1 ZBTB40 RAD21 ZNF335 NME9 A4GNT GC03P138286
GH03I138410 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.5 -82.3 -82301 3.7 ETV1 BACH1 ZNF644 ZBTB40 ZNF507 RELA FOSL1 ZNF766 VEZF1 FOS NME9 MRAS ESYT3 LOC105374129 GC03P138407 GC03M138428
GH03I138417 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -88.3 -88346 1.8 CTCF FOXA2 ZSCAN4 SIN3A ZNF2 RAD21 GATA3 ZNF316 ZNF143 SMC3 NME9 LOC105374129 GC03P138407 GC03M138428
GH03I138367 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.5 -37.7 -37652 1.2 RFX1 EGR1 ZSCAN4 BMI1 NME9 MRAS GC03M138344 GC03P138407
GH03I138387 Enhancer 0.9 Ensembl dbSUPER 10.8 -54.0 -53952 0.2 HDAC1 TEAD4 TAL1 TCF12 CTBP1 NCOR1 CBFA2T2 TRIM24 SOX6 CBFA2T3 NME9 GC03P138407 GC03M138344 MRAS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NME9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NME9 Gene

Genomic Locations for NME9 Gene
68,713 bases
Minus strand

Genomic View for NME9 Gene

Genes around NME9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME9 Gene

Proteins for NME9 Gene

  • Protein details for NME9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thioredoxin domain-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • Q7Z4A8
    • Q8N1V7

    Protein attributes for NME9 Gene

    330 amino acids
    Molecular mass:
    36856 Da
    Quaternary structure:
    • Monomer and homodimer.
    • Shows no detectable enzyme activity.

    Alternative splice isoforms for NME9 Gene


neXtProt entry for NME9 Gene

Post-translational modifications for NME9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NME9 Gene

Domains & Families for NME9 Gene

Gene Families for NME9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NME9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NDK family.
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME9: view

Function for NME9 Gene

Molecular function for NME9 Gene

UniProtKB/Swiss-Prot Function:
May be a regulator of microtubule physiology.

Phenotypes From GWAS Catalog for NME9 Gene

Gene Ontology (GO) - Molecular Function for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA --
genes like me logo Genes that share ontologies with NME9: view
genes like me logo Genes that share phenotypes with NME9: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME9 Gene

Localization for NME9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME9 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. Detected in cilia of lung epithelium, and associated with the spermatid tail and manchette (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME9 gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 3

Gene Ontology (GO) - Cellular Components for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005623 cell IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with NME9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NME9 Gene

Pathways & Interactions for NME9 Gene

No Data Available

Interacting Proteins for NME9 Gene

Gene Ontology (GO) - Biological Process for NME9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with NME9: view

No data available for Pathways by source and SIGNOR curated interactions for NME9 Gene

Drugs & Compounds for NME9 Gene

No Compound Related Data Available

Transcripts for NME9 Gene

Unigene Clusters for NME9 Gene

NME/NM23 family member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME9 Gene

No ASD Table

Relevant External Links for NME9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NME9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME9 Gene

Protein differential expression in normal tissues from HIPED for NME9 Gene

This gene is overexpressed in Neutrophil (45.5) and Heart (23.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NME9 Gene

Protein tissue co-expression partners for NME9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NME9 Gene:


SOURCE GeneReport for Unigene cluster for NME9 Gene:


mRNA Expression by UniProt/SwissProt for NME9 Gene:

Tissue specificity: Detected at very low levels in testis, lung and brain.

Evidence on tissue expression from TISSUES for NME9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NME9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME9 Gene

Orthologs for NME9 Gene

This gene was present in the common ancestor of animals.

Orthologs for NME9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TXNDC6 33
  • 99.46 (n)
NME9 34
  • 94 (a)
(Bos Taurus)
Mammalia NME9 33 34
  • 88.76 (n)
(Canis familiaris)
Mammalia NME9 33 34
  • 87.95 (n)
(Rattus norvegicus)
Mammalia Nme9 33
  • 80.93 (n)
(Mus musculus)
Mammalia Nme9 33 16
  • 80.79 (n)
1600029I14Rik 34
  • 80 (a)
(Monodelphis domestica)
Mammalia NME9 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia NME9 34
  • 45 (a)
(Danio rerio)
Actinopterygii nme8 34
  • 22 (a)
fruit fly
(Drosophila melanogaster)
Insecta nmdyn-D6 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 18 (a)
Species where no ortholog for NME9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NME9 Gene

Gene Tree for NME9 (if available)
Gene Tree for NME9 (if available)

Paralogs for NME9 Gene

Paralogs for NME9 Gene

(2) SIMAP similar genes for NME9 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with NME9: view

Variants for NME9 Gene

Sequence variations from dbSNP and Humsavar for NME9 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs9289556 benign, not specified 138,314,339(-) C/T 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000022483 -- 138,262,137(-) G/A/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000266002 -- 138,318,274(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000282302 -- 138,327,874(-) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000327694 -- 138,269,253(-) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NME9 Gene

Variant ID Type Subtype PubMed ID
nsv4030 CNV insertion 18451855
nsv428422 CNV gain+loss 18775914
nsv528349 CNV loss 19592680
nsv822263 CNV loss 20364138
nsv822264 CNV loss 20364138

Variation tolerance for NME9 Gene

Residual Variation Intolerance Score: 56.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NME9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME9 Gene

Disorders for NME9 Gene

Additional Disease Information for NME9

No disorders were found for NME9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME9 Gene

Publications for NME9 Gene

  1. Characterization of human thioredoxin-like 2. A novel microtubule-binding thioredoxin expressed predominantly in the cilia of lung airway epithelium and spermatid manchette and axoneme. (PMID: 12569107) Sadek CM … Miranda-Vizuete A (The Journal of biological chemistry 2003) 2 3 4 22 58
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T … Bobe J (BMC evolutionary biology 2009) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Thioredoxin-like protein 2b facilitates colon cancer cell proliferation and inhibits apoptosis via NF-κB pathway. (PMID: 25555669) Lu Y … Fan D (Cancer letters 2015) 3 58
  5. Thioredoxin-like protein 2 is overexpressed in colon cancer and promotes cancer cell metastasis by interaction with ran. (PMID: 23311631) Lu Y … Fan D (Antioxidants & redox signaling 2013) 3 58

Products for NME9 Gene

Sources for NME9 Gene

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