Aliases for NME7 Gene
External Ids for NME7 Gene
Previous GeneCards Identifiers for NME7 Gene
This gene encodes a member of the non-metastatic expressed family of nucleoside diphosphate kinases. Members of this family are enzymes that catalyzes phosphate transfer from nucleoside triphosphates to nucleoside diphosphates. This protein contains two kinase domains, one of which is involved in autophosphorylation and the other may be inactive. This protein localizes to the centrosome and functions as a component of the gamma-tubulin ring complex which plays a role in microtubule organization. Mutations in this gene may be associated with venous thromboembolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
GeneCards Summary for NME7 Gene
NME7 (NME/NM23 Family Member 7) is a Protein Coding gene. Diseases associated with NME7 include Dextrocardia With Situs Inversus and Deafness, Autosomal Dominant 7. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.
UniProtKB/Swiss-Prot Summary for NME7 Gene
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.