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NME5 (NME/NM23 Family Member 5) is a Protein Coding gene. Diseases associated with NME5 include Nemaline Myopathy 5 and Primary Ciliary Dyskinesia. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004550 | nucleoside diphosphate kinase activity | TAS,IEA | -- |
GO:0005515 | protein binding | IPI | 16189514 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005575 | cellular_component | ND | -- |
GO:0005576 | extracellular region | IEA | -- |
GO:0036126 | sperm flagellum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis | ||
2 | purine nucleotides de novo biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003351 | epithelial cilium movement | IEA | -- |
GO:0006165 | nucleoside diphosphate phosphorylation | IEA | -- |
GO:0006183 | GTP biosynthetic process | IEA | -- |
GO:0006228 | UTP biosynthetic process | IEA | -- |
GO:0006241 | CTP biosynthetic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
2'-Deoxyinosine triphosphate |
|
16595-02-1 |
|
|||
ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
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||
dADP |
|
2793-06-8 |
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dcdp |
|
800-73-7 |
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Deoxyuridine triphosphate |
|
1173-82-6 |
|
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||
SP3: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NME5 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NME5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NME5 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Nme5 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nme5 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NME5 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | NME5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NME5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NME5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nme5 30 |
|
||
Str.14959 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.17997 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nme5 30 31 |
|
OneToOne | |
Dr.14439 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.5032 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | nmdyn-D6 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | AT1G17410 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os02g0565100 30 |
|
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Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.6539 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3575884 | CNV | gain | 25503493 |
esv3606913 | CNV | gain | 21293372 |
nsv1114734 | CNV | deletion | 24896259 |
Disorder | Aliases | PubMed IDs |
---|---|---|
nemaline myopathy 5 |
|
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primary ciliary dyskinesia |
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|