NME5 Gene (Protein Coding)

NME/NM23 Family Member 5

GC05M138115
GIFtS:
39
See more...

Aliases for NME5 Gene

Aliases for NME5 Gene

  • NME/NM23 Family Member 5 2 3 5
  • Non-Metastatic Cells 5, Protein Expressed In (Nucleoside-Diphosphate Kinase) 2 3
  • Nucleoside Diphosphate Kinase Homolog 5 3 4
  • Inhibitor Of P53-Induced Apoptosis-Beta 3 4
  • Testis-Specific Nm23 Homolog 3 4
  • NDP Kinase Homolog 5 3 4
  • IPIA-Beta 3 4
  • NDK-H 5 3 4
  • Nm23-H5 2 4
  • RSPH23 2 3
  • Non-Metastatic Cells 5 Protein Expressed In 3
  • Radial Spoke 23 Homolog (Chlamydomonas) 2
  • Radial Spoke 23 Homolog 3
  • NM23-H5 3
  • NM23H5 3
  • NME5 5

External Ids for NME5 Gene

Previous GeneCards Identifiers for NME5 Gene

  • GC05M137326
  • GC05M138126
  • GC05M137481
  • GC05M137527
  • GC05M137478
  • GC05M137451
  • GC05M132641

Summaries for NME5 Gene

GeneCards Summary for NME5 Gene

NME5 (NME/NM23 Family Member 5) is a Protein Coding gene. Diseases associated with NME5 include Nemaline Myopathy 5 and Primary Ciliary Dyskinesia. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME8.

UniProtKB/Swiss-Prot Summary for NME5 Gene

  • Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).

Additional gene information for NME5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NME5 Gene

Genomics for NME5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NME5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NME5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NME5

Top Transcription factor binding sites by QIAGEN in the NME5 gene promoter:
  • AML1a
  • AREB6
  • c-Myc
  • C/EBPalpha
  • FOXL1
  • IRF-1
  • Max1
  • Pax-2
  • Pax-2a
  • Pax-2b

Genomic Locations for NME5 Gene

Genomic Locations for NME5 Gene
chr5:138,115,175-138,139,471
(GRCh38/hg38)
Size:
24,297 bases
Orientation:
Minus strand
chr5:137,450,861-137,475,132
(GRCh37/hg19)
Size:
24,272 bases
Orientation:
Minus strand

Genomic View for NME5 Gene

Genes around NME5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME5 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NME5 Gene

Proteins for NME5 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NME5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56597-NDK5_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase homolog 5
    Protein Accession:
    P56597
    Secondary Accessions:
    • B2R5G7

    Protein attributes for NME5 Gene

    Size:
    212 amino acids
    Molecular mass:
    24236 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME5 Gene

Protein Expression for NME5 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for NME5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NME5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NME5 Gene

Domains & Families for NME5 Gene

Gene Families for NME5 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NME5 Gene

InterPro:
Blocks:
  • Nucleoside diphosphate kinase
  • Dpy-30
ProtoNet:

Suggested Antigen Peptide Sequences for NME5 Gene

GenScript: Design optimal peptide antigens:
  • nm23-H5 (NDK5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P56597

UniProtKB/Swiss-Prot:

NDK5_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME5: view

Function for NME5 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NME5 Gene

UniProtKB/Swiss-Prot Function:
Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity).
GENATLAS Biochemistry:
non-metastatic cells 5,protein,with a nm23 nucleoside diphosphate kinase gene family,specifically expressed in testis germinal cells,expressed in germ cell,kidney,ovary,parathyroid,testis,uterus,involved in the phosphorylation of nucleoside diphosphates and putatively in spermatogenesis

Phenotypes From GWAS Catalog for NME5 Gene

Gene Ontology (GO) - Molecular Function for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity TAS,IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with NME5: view
genes like me logo Genes that share phenotypes with NME5: view

Animal Models for NME5 Gene

MGI Knock Outs for NME5:

Animal Model Products

  • Taconic Biosciences Mouse Models for NME5

CRISPR Products

miRNA for NME5 Gene

miRTarBase miRNAs that target NME5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NME5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME5 Gene

Localization for NME5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME5 gene
Compartment Confidence
extracellular 3
cytosol 3
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region IEA --
GO:0036126 sperm flagellum IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME5 Gene

Pathways & Interactions for NME5 Gene

genes like me logo Genes that share pathways with NME5: view

Gene Ontology (GO) - Biological Process for NME5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IEA --
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME5: view

No data available for SIGNOR curated interactions for NME5 Gene

Drugs & Compounds for NME5 Gene

Products:

  1. Drug

(11) Drugs for NME5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dATP Experimental Pharma Agonist, Full agonist 0
dctp Experimental Pharma 0
dgtp Experimental Pharma 0

(11) Additional Compounds for NME5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxyinosine 5'-triphosphate
  • 2'-Deoxyinosine-5'-triphosphate
  • Deoxyinosine 5'-triphosphate
  • 2'-Deoxyinosine 5'-triphosphoric acid
  • 2'-Deoxyinosine triphosphoric acid
 16595-02-1
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • Deoxyadenosine diphosphate
 2793-06-8
dcdp
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • D-1beta-Ribofuranosylcytosine diphosphate
  • Deoxycytidine diphosphate
  • 2'-Deoxycytidine 5'-diphosphoric acid
 800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine 5'-triphosphoric acid
  • Deoxyuridine triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
 1173-82-6
genes like me logo Genes that share compounds with NME5: view

Transcripts for NME5 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NME5 Gene

1 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NME5

Alternative Splicing Database (ASD) splice patterns (SP) for NME5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: - -
SP3:

Relevant External Links for NME5 Gene

GeneLoc Exon Structure for
NME5

Expression for NME5 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NME5 Gene

mRNA expression in normal human tissues for NME5 Gene
mRNA expression by BioGPS for NME5 GenemRNA expression by GTEx for NME5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NME5 Gene

This gene is overexpressed in Testis (x6.1).

Protein differential expression in normal tissues from HIPED for NME5 Gene

This gene is overexpressed in Plasma (57.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NME5 Gene



Protein tissue co-expression partners for NME5 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NME5

SOURCE GeneReport for Unigene cluster for NME5 Gene:

Hs.730856

mRNA Expression by UniProt/SwissProt for NME5 Gene:

P56597-NDK5_HUMAN
Tissue specificity: Specifically expressed in testis germinal cells.

Evidence on tissue expression from TISSUES for NME5 Gene

  • Nervous system(4.8)
  • Kidney(4.4)
  • Gall bladder(4.2)
genes like me logo Genes that share expression patterns with NME5: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NME5 Gene

Orthologs for NME5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia NME5 30 31
  • 99.37 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia NME5 30 31
  • 91.55 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia NME5 30
  • 90.68 (n)
Rat
(Rattus norvegicus)
 Mammalia Nme5 30
  • 84.04 (n)
Mouse
(Mus musculus)
 Mammalia Nme5 30 17 31
  • 83.57 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia NME5 31
  • 82 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia NME5 31
  • 76 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves NME5 30 31
  • 71.45 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia NME5 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia nme5 30
  • 72.04 (n)
Str.14959 30
African clawed frog
(Xenopus laevis)
 Amphibia Xl.17997 30
Zebrafish
(Danio rerio)
 Actinopterygii nme5 30 31
  • 65.05 (n)
 OneToOne
Dr.14439 30
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.5032 30
Fruit Fly
(Drosophila melanogaster)
 Insecta nmdyn-D6 31
  • 36 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons AT1G17410 30
  • 49.65 (n)
Rice
(Oryza sativa)
 Liliopsida Os02g0565100 30
  • 49.25 (n)
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 52 (a)
 OneToOne
Sea Vase
(Ciona intestinalis)
 Ascidiacea Cin.6539 30
Species where no ortholog for NME5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NME5 Gene

ENSEMBL:
Gene Tree for NME5 (if available)
TreeFam:
Gene Tree for NME5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NME5: view image

Paralogs for NME5 Gene

Paralogs for NME5 Gene

(3) SIMAP similar genes for NME5 Gene using alignment to 1 proteins:

  • NDK5_HUMAN
genes like me logo Genes that share paralogs with NME5: view

Variants for NME5 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for NME5 Gene

Structural Variations from Database of Genomic Variants (DGV) for NME5 Gene

Variant ID Type Subtype PubMed ID
esv3575884 CNV gain 25503493
esv3606913 CNV gain 21293372
nsv1114734 CNV deletion 24896259

Variation tolerance for NME5 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NME5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NME5 Gene

Disorders for NME5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NME5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nemaline myopathy 5
  • nem5
primary ciliary dyskinesia
  • pcd
- elite association - COSMIC cancer census association via MalaCards
Search NME5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NME5

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NME5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME5 Gene

Publications for NME5 Gene

  1. A new human nm23 homologue (nm23-H5) specifically expressed in testis germinal cells. (PMID: 9742940) Munier A … Lacombe ML (FEBS letters 1998) 2 3 4 23
  2. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T … Bobe J (BMC evolutionary biology 2009) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

ExternalLinks

View latest publications for NME5 gene in Mastermind

Products for NME5 Gene

  • Addgene plasmids for NME5
  • Signalway Proteins for NME5

Sources for NME5 Gene