The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008] See more...

Aliases for NME4 Gene

Aliases for NME4 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 4 2 3 5
  • Nucleoside Diphosphate Kinase, Mitochondrial 3 4
  • Non-Metastatic Cells 4, Protein Expressed In 2 3
  • Nucleoside Diphosphate Kinase D 3 4
  • NDP Kinase, Mitochondrial 3 4
  • EC 2.7.4.6 4 52
  • Nm23-H4 3 4
  • NDPKD 3 4
  • NDK 3 4
  • NDP Kinase D 3
  • NDPK-D 3
  • NM23H4 3
  • NM23D 4

External Ids for NME4 Gene

Previous GeneCards Identifiers for NME4 Gene

  • GC16P000466
  • GC16P000387
  • GC16P000446
  • GC16P000368

Summaries for NME4 Gene

Entrez Gene Summary for NME4 Gene

  • The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]

GeneCards Summary for NME4 Gene

NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4) is a Protein Coding gene. Diseases associated with NME4 include Nemaline Myopathy 4 and Gaucher Disease, Type Iii. Among its related pathways are ATP/ITP metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME3.

UniProtKB/Swiss-Prot Summary for NME4 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).

Gene Wiki entry for NME4 Gene

Additional gene information for NME4 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NME4 Gene

Genomics for NME4 Gene

GeneHancer (GH) Regulatory Elements for NME4 Gene

Promoters and enhancers for NME4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J000396 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 539.5 +3.2 3176 7.8 HNRNPK EP300 CTCF TCF12 NRF1 POLR2G USF1 NCOR1 GTF2E2 PHF8 NME4 DECR2 ENSG00000261505 WDR90 RHOT2 AXIN1 LINC02867 JMJD8 UBE2I WASH4P
GH16J000395 Enhancer 0.3 Ensembl 500.7 -1.4 -1424 0.2 RBM25 ZBTB33 NME4 piR-56497-054
GH16J000423 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 34 +30.1 30109 6.5 HNRNPK EP300 CTCF POLR2G PHF8 JUND FOS ZFX ZIC2 POLR2A RAB11FIP3 DECR2 NME4 CAPN15 PRR35 NHLRC4 PIGQ PGAP6 ENSG00000276984 lnc-DECR2-3
GH16J000391 Enhancer 1.1 Ensembl ENCODE 39.1 -4.2 -4209 1.8 CTCF RBAK FOS ZNF639 ZIC2 GABPA TRIM28 REST RAD21 CTBP1 NME4 ENSG00000236829 piR-56497-054 LOC100134368
GH16J000404 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 25.3 +8.9 8903 1.8 EP300 POLR2G ZIC2 KDM6A ZNF263 TCF7 ZBTB25 MYC TGIF2 CTBP1 DECR2 NME4 HSALNG0108729 lnc-TMEM8A-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NME4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NME4

Top Transcription factor binding sites by QIAGEN in the NME4 gene promoter:
  • AREB6
  • GR
  • GR-alpha
  • GR-beta
  • ITF-2
  • NRSF form 1
  • NRSF form 2
  • PPAR-alpha
  • S8
  • Tal-1beta

Genomic Locations for NME4 Gene

Genomic Locations for NME4 Gene
chr16:396,725-410,367
(GRCh38/hg38)
Size:
13,643 bases
Orientation:
Plus strand
chr16:446,725-460,367
(GRCh37/hg19)
Size:
13,643 bases
Orientation:
Plus strand

Genomic View for NME4 Gene

Genes around NME4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME4 Gene

Proteins for NME4 Gene

  • Protein details for NME4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00746-NDKM_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase, mitochondrial
    Protein Accession:
    O00746
    Secondary Accessions:
    • A2IDD0
    • Q5U0M9

    Protein attributes for NME4 Gene

    Size:
    187 amino acids
    Molecular mass:
    20659 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homohexamer (PubMed:10799505). Interacts with OPA1 (PubMed:23150663). Interacts with CAPN8 (By similarity).

    Three dimensional structures from OCA and Proteopedia for NME4 Gene

    Alternative splice isoforms for NME4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME4 Gene

Selected DME Specific Peptides for NME4 Gene

O00746:
  • AAPGTIR
  • SGPVVAMV
  • PGTIRGD
  • PVVAMVWEG
  • KPDGVQR

Post-translational modifications for NME4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NME4 Gene

Gene Families for NME4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NME4 Gene

Blocks:
  • Nucleoside diphosphate kinase
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NME4 Gene

GenScript: Design optimal peptide antigens:
  • Non-metastatic cells 4, protein expressed in (A2IDC8_HUMAN)
  • Nucleoside diphosphate kinase (A2IDD0_HUMAN)
  • Nucleoside diphosphate kinase (F2Z2X0_HUMAN)
  • nm23-H4 (NDKM_HUMAN)
  • Nucleoside diphosphate kinase (Q4TT34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O00746

UniProtKB/Swiss-Prot:

NDKM_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME4: view

Function for NME4 Gene

Molecular function for NME4 Gene

UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6;.
GENATLAS Biochemistry:
non-metastatic cells 4,protein,nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates and putatively involved int intramitochondrial GTP metabolism

Enzyme Numbers (IUBMB) for NME4 Gene

Phenotypes From GWAS Catalog for NME4 Gene

Gene Ontology (GO) - Molecular Function for NME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA,IEA 21873635
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0008289 lipid binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NME4: view
genes like me logo Genes that share phenotypes with NME4: view

Animal Models for NME4 Gene

MGI Knock Outs for NME4:
  • Nme4 Nme4<tm1a(EUCOMM)Wtsi>

Animal Model Products

  • Taconic Biosciences Mouse Models for NME4

CRISPR Products

Clone Products

  • Addgene plasmids for NME4

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NME4 Gene

Localization for NME4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME4 Gene

Mitochondrion intermembrane space; Peripheral membrane protein. Mitochondrion matrix. Note=Predominantly localized in the mitochondrion intermembrane space (PubMed:18635542). Colocalizes with OPA1 in mitochondria (PubMed:24970086). {ECO:0000269 PubMed:18635542, ECO:0000269 PubMed:24970086}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME4 gene
Compartment Confidence
mitochondrion 4
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005758 mitochondrial intermembrane space IDA 23150663
GO:0005759 mitochondrial matrix IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NME4: view

Pathways & Interactions for NME4 Gene

genes like me logo Genes that share pathways with NME4: view

Pathways by source for NME4 Gene

1 GeneGo (Thomson Reuters) pathway for NME4 Gene
  • ATP/ITP metabolism

Gene Ontology (GO) - Biological Process for NME4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006163 purine nucleotide metabolic process IBA 21873635
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006220 pyrimidine nucleotide metabolic process IBA 21873635
GO:0006228 UTP biosynthetic process IEA --
genes like me logo Genes that share ontologies with NME4: view

No data available for SIGNOR curated interactions for NME4 Gene

Drugs & Compounds for NME4 Gene

(12) Drugs for NME4 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
dATP Experimental Pharma Full agonist, Agonist 0
dctp Experimental Pharma 0

(17) Additional Compounds for NME4 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
2'-Deoxyinosine triphosphate
  • 2'-Deoxyinosine 5'-triphosphate
  • 2'-Deoxyinosine-5'-triphosphate
  • Deoxyinosine 5'-triphosphate
  • 2'-Deoxyinosine 5'-triphosphoric acid
  • 2'-Deoxyinosine triphosphoric acid
16595-02-1
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • D-1beta-Ribofuranosylcytosine diphosphate
  • Deoxycytidine diphosphate
  • 2'-Deoxycytidine 5'-diphosphoric acid
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine 5'-triphosphoric acid
  • Deoxyuridine triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
1173-82-6
genes like me logo Genes that share compounds with NME4: view

Transcripts for NME4 Gene

mRNA/cDNA for NME4 Gene

7 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for NME4

Alternative Splicing Database (ASD) splice patterns (SP) for NME4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b
SP1: - - -
SP2: -
SP3: -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7:

Relevant External Links for NME4 Gene

GeneLoc Exon Structure for
NME4

Expression for NME4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NME4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NME4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (34.6), Urinary Bladder (10.9), and Fetal gut (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NME4 Gene



Protein tissue co-expression partners for NME4 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NME4

SOURCE GeneReport for Unigene cluster for NME4 Gene:

Hs.9235

mRNA Expression by UniProt/SwissProt for NME4 Gene:

O00746-NDKM_HUMAN
Tissue specificity: Widely distributed. Found at very high levels in prostate, heart, liver, small intestine, and skeletal muscle tissues, and in low amounts in the brain and in blood leukocytes.

Evidence on tissue expression from TISSUES for NME4 Gene

  • Stomach(4.3)
  • Skin(4.2)
  • Nervous system(2.6)
  • Liver(2)
genes like me logo Genes that share expression patterns with NME4: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME4 Gene

Orthologs for NME4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NME4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NME4 31 30
  • 96.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NME4 30
  • 86.63 (n)
-- 31
  • 80 (a)
OneToMany
-- 31
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nme4 30
  • 82.7 (n)
mouse
(Mus musculus)
Mammalia Nme4 17 31 30
  • 82.16 (n)
oppossum
(Monodelphis domestica)
Mammalia NME4 31
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NME4 31
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves NME4 31
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NME4 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nme4 30
  • 67.06 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9894 30
zebrafish
(Danio rerio)
Actinopterygii nme4 31 30
  • 67.33 (n)
OneToOne
zgc56482 30
fruit fly
(Drosophila melanogaster)
Insecta awd 31
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ndk-1 31
  • 52 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 31
  • 49 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToMany
Species where no ortholog for NME4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NME4 Gene

ENSEMBL:
Gene Tree for NME4 (if available)
TreeFam:
Gene Tree for NME4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NME4: view image

Paralogs for NME4 Gene

Paralogs for NME4 Gene

(8) SIMAP similar genes for NME4 Gene using alignment to 7 proteins:

  • NDKM_HUMAN
  • A2IDC9_HUMAN
  • A2IDD0_HUMAN
  • F2Z297_HUMAN
  • F2Z2X0_HUMAN
  • H0Y6J0_HUMAN
  • Q4TT34_HUMAN

Pseudogenes.org Pseudogenes for NME4 Gene

genes like me logo Genes that share paralogs with NME4: view

Variants for NME4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NME4 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
720751 Benign: not provided 399,399(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NME4 Gene

Structural Variations from Database of Genomic Variants (DGV) for NME4 Gene

Variant ID Type Subtype PubMed ID
dgv32n68 CNV loss 17160897
dgv4809n54 CNV loss 21841781
dgv4810n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
esv3637563 CNV gain 21293372
nsv1069891 CNV deletion 25765185
nsv457303 CNV loss 19166990
nsv570954 CNV loss 21841781
nsv570956 CNV gain 21841781

Variation tolerance for NME4 Gene

Residual Variation Intolerance Score: 81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NME4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NME4 Gene

Disorders for NME4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NME4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
nemaline myopathy 4
  • nem4
gaucher disease, type iii
  • gd iii
- elite association - COSMIC cancer census association via MalaCards
Search NME4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NME4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NME4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME4 Gene

Publications for NME4 Gene

  1. nm23-H4, a new member of the family of human nm23/nucleoside diphosphate kinase genes localised on chromosome 16p13. (PMID: 9099850) Milon L … Lacombe ML (Human genetics 1997) 2 3 4 23 54
  2. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. (PMID: 10799505) Milon L … Lacombe ML (The Journal of biological chemistry 2000) 3 4 23 54
  3. Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling. (PMID: 24970086) Boissan M … Chavrier P (Science (New York, N.Y.) 2014) 3 4 54
  4. Dual function of mitochondrial Nm23-H4 protein in phosphotransfer and intermembrane lipid transfer: a cardiolipin-dependent switch. (PMID: 23150663) Schlattner U … Kagan VE (The Journal of biological chemistry 2013) 3 4 54
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54

Products for NME4 Gene

Sources for NME4 Gene