Aliases for NME3 Gene
External Ids for NME3 Gene
Previous GeneCards Identifiers for NME3 Gene
GeneCards Summary for NME3 Gene
NME3 (NME/NM23 Nucleoside Diphosphate Kinase 3) is a Protein Coding gene. Diseases associated with NME3 include Lipase Deficiency, Combined and Nephronophthisis. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity. An important paralog of this gene is NME1.
UniProtKB/Swiss-Prot Summary for NME3 Gene
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.