NME2P1 Gene (Pseudogene)

NME2 Pseudogene 1

GC12P120282
GIFtS:
20
See more...

Aliases for NME2P1 Gene

Aliases for NME2P1 Gene

  • NME2 Pseudogene 1 2 3 5
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 1 2 3
  • NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1 2 3
  • EC 2.7.4.6 4 51
  • Nucleoside Diphosphate Kinase B-Like Pseudogene 3
  • Putative Nucleoside Diphosphate Kinase 4
  • NDP Kinase 4
  • NME2P1 5
  • NDK 4

External Ids for NME2P1 Gene

Previous GeneCards Identifiers for NME2P1 Gene

  • GC12P119131
  • GC12P119182
  • GC12P120719
  • GC12P117728

Summaries for NME2P1 Gene

GeneCards Summary for NME2P1 Gene

NME2P1 (NME2 Pseudogene 1) is a Pseudogene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity.

UniProtKB/Swiss-Prot Summary for NME2P1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Additional gene information for NME2P1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NME2P1 Gene

Genomics for NME2P1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for NME2P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J120282 Enhancer 0.7 Ensembl ENCODE 250.7 +1.0 1017 2.1 ZNF341 ZBTB40 ZBTB33 L3MBTL2 SP1 ZNF512 PKNOX1 ZSCAN29 NME2P1 lnc-PXN-1 SIRT4 lnc-SIRT4-3 RF00017-1306 PXN RF00017-1304
GH12J120290 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.5 +9.9 9940 3.5 ZSCAN16 ZBTB10 BCL11A SP1 CEBPA ZNF217 SIX5 CBX2 MNT IKZF1 SIRT4 RNU4-1 RNU4-2 GCN1 RPL31P52 RAB35 SRSF9 CABP1 ENSG00000256008 CIT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NME2P1 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the NME2P1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • STAT3

Genomic Locations for NME2P1 Gene

Latest Assembly
chr12:120,282,218-120,282,856
(GRCh38/hg38)
Size:
639 bases
Orientation:
Plus strand

Previous Assembly
chr12:120,720,021-120,720,659
(GRCh37/hg19 by Entrez Gene)
Size:
639 bases
Orientation:
Plus strand

chr12:120,719,940-120,720,632
(GRCh37/hg19 by Ensembl)
Size:
693 bases
Orientation:
Plus strand

Genomic View for NME2P1 Gene

Genes around NME2P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2P1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NME2P1 Gene

Proteins for NME2P1 Gene

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  2. Protein products for research
  3. Assay products for research

  • Protein details for NME2P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60361-NDK8_HUMAN
    Recommended name:
    Putative nucleoside diphosphate kinase
    Protein Accession:
    O60361

    Protein attributes for NME2P1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NME2P1 Gene

Protein Expression for NME2P1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for NME2P1 Gene

O60361:
  • MLGETNPADSKPG
  • NIIHGSD
  • MVWEGLNVVKTGR
  • SGPVVAMV
  • PGTIRGD
  • RFEQKGF
  • HYIDLKDRPF
  • PVVAMVWEG
  • PFFPGLV

Post-translational modifications for NME2P1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NME2P1 Gene

Protein Domains for NME2P1 Gene

InterPro:
Blocks:
  • Nucleoside diphosphate kinase
ProtoNet:

Suggested Antigen Peptide Sequences for NME2P1 Gene

GenScript: Design optimal peptide antigens:
  • Putative nucleoside diphosphate kinase (NDK8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60361

UniProtKB/Swiss-Prot:

NDK8_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2P1: view

No data available for Gene Families for NME2P1 Gene

Function for NME2P1 Gene

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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Molecular function for NME2P1 Gene

UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10030};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10030};.

Enzyme Numbers (IUBMB) for NME2P1 Gene

Phenotypes From GWAS Catalog for NME2P1 Gene

Gene Ontology (GO) - Molecular Function for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME2P1: view

Phenotypes for NME2P1 Gene

GenomeRNAi human phenotypes for NME2P1:
genes like me logo Genes that share phenotypes with NME2P1: view

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME2P1 Gene

Localization for NME2P1 Gene

Gene Ontology (GO) - Cellular Components for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with NME2P1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NME2P1 Gene

Pathways & Interactions for NME2P1 Gene

genes like me logo Genes that share pathways with NME2P1: view

Pathways by source for NME2P1 Gene

1 GeneGo (Thomson Reuters) pathway for NME2P1 Gene
  • ATP/ITP metabolism

Interacting Proteins for NME2P1 Gene

Selected Interacting proteins: O60361-NDK8_HUMAN for NME2P1 Gene via IID

Gene Ontology (GO) - Biological Process for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0042981 regulation of apoptotic process IBA 21873635
genes like me logo Genes that share ontologies with NME2P1: view

No data available for SIGNOR curated interactions for NME2P1 Gene

Drugs & Compounds for NME2P1 Gene

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  1. Drug products for research

(7) Drugs for NME2P1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for NME2P1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
 491-97-4
genes like me logo Genes that share compounds with NME2P1: view

Transcripts for NME2P1 Gene

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mRNA/cDNA for NME2P1 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NME2P1 Gene

No ASD Table

Relevant External Links for NME2P1 Gene

GeneLoc Exon Structure for
NME2P1

Expression for NME2P1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NME2P1 Gene

mRNA expression in normal human tissues for NME2P1 Gene
mRNA expression by GTEx for NME2P1 Gene

mRNA differential expression in normal tissues according to GTEx for NME2P1 Gene

This gene is overexpressed in Pancreas (x6.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for NME2P1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Peripheral blood mononuclear cells (8.3), Tlymphocyte (8.3), Monocytes (7.8), Brain (6.3), and Cervix (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NME2P1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NME2P1

genes like me logo Genes that share expression patterns with NME2P1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME2P1 Gene

Orthologs for NME2P1 Gene

Evolution for NME2P1 Gene

ENSEMBL:
Gene Tree for NME2P1 (if available)
TreeFam:
Gene Tree for NME2P1 (if available)

No data available for Orthologs for NME2P1 Gene

Paralogs for NME2P1 Gene

(8) SIMAP similar genes for NME2P1 Gene using alignment to 1 proteins:

  • NDK8_HUMAN
genes like me logo Genes that share paralogs with NME2P1: view

No data available for Paralogs for NME2P1 Gene

Variants for NME2P1 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Additional Variant Information for NME2P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME2P1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , dbSNP identifiers (rs#s) for variants without ClinVar clinical significance , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NME2P1 Gene

Disorders for NME2P1 Gene

Additional Disease Information for NME2P1

Open Targets Platform
Open Targets Platform

No disorders were found for NME2P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME2P1 Gene

Publications for NME2P1 Gene

  1. BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A. (PMID: 33001583) Mao CG … Deng B (Thoracic cancer 2020) 3
  2. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D. (PMID: 31980649) Kennedy SA … Kolch W (Nature communications 2020) 3
  3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  4. Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development. (PMID: 31343991) Wang P … Xiong Y (The Journal of clinical investigation 2019) 3
  5. PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation. (PMID: 31300519) Guardia-Laguarta C … Przedborski S (The Journal of neuroscience : the official journal of the Society for Neuroscience 2019) 3

ExternalLinks

View latest publications for NME2P1 gene in Mastermind

Products for NME2P1 Gene

Sources for NME2P1 Gene