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NME2P1 Gene(Pseudogene)

NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1

GCID:
GC12P120282
GIFtS:
25
Genes Participants
UDN Logo

Aliases for NME2P1 Gene

Aliases for NME2P1 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1 2 3 5
  • EC 2.7.4.6 4 56
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 1 2
  • NDP Kinase 4
  • NDK 4

External Ids for NME2P1 Gene

Previous GeneCards Identifiers for NME2P1 Gene

  • GC12P119131
  • GC12P119182
  • GC12P120719
  • GC12P117728

Summaries for NME2P1 Gene

GeneCards Summary for NME2P1 Gene

NME2P1 (NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1) is a Pseudogene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity.

UniProtKB/Swiss-Prot for NME2P1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Additional gene information for NME2P1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2P1 Gene

Genomics for NME2P1 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for NME2P1 Gene

Promoters and enhancers for NME2P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12I120282 Enhancer 0.5 ENCODE 550.8 +1.4 1354 1.3 SP1 L3MBTL2 ZNF512 ZNF341 ZSCAN29 ZBTB33 ZBTB40 NME2P1 SIRT4 GC12M120292 RNU4-2
GH12I120290 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 6.5 +10.0 9977 3.4 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SIRT4 GC12M120292 GC12M120294 RNU4-1 RNU4-2 GCN1 RAB35 PXN SRSF9 RPLP0
GH12I120286 Enhancer 0.6 ENCODE 0.8 +4.9 4936 2 SMARCE1 KLF4 ZNF121 ZNF217 GATA3 CTBP1 SCRT2 ZBTB33 PXN GC12M120292 NME2P1 RNU4-2
GH12I120267 Enhancer 0.7 ENCODE dbSUPER 0.4 -14.2 -14205 1.4 ELF3 ZNF189 ZNF366 ZNF512 ZNF580 NR2F2 SIRT4 PXN NME2P1
GH12I120276 Enhancer 0.5 dbSUPER 0.4 -5.6 -5616 0.5 TEAD1 ADNP CEBPA CEBPB CEBPG TEAD3 SIRT4 GCN1 NME2P1 PXN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NME2P1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NME2P1 gene promoter:

Genomic Locations for NME2P1 Gene

Genomic Locations for NME2P1 Gene
chr12:120,282,253-120,282,865
(GRCh38/hg38)
Size:
613 bases
Orientation:
Plus strand
chr12:120,719,940-120,720,668
(GRCh37/hg19)

Genomic View for NME2P1 Gene

Genes around NME2P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2P1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for NME2P1 Gene

Proteins for NME2P1 Gene

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  1. Antibody
  2. Protein
  3. Assay

  • Protein details for NME2P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60361-NDK8_HUMAN
    Recommended name:
    Putative nucleoside diphosphate kinase
    Protein Accession:
    O60361

    Protein attributes for NME2P1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NME2P1 Gene

Protein Expression for NME2P1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for NME2P1 Gene

O60361:
  • MLGETNPADSKPG
  • NIIHGSD
  • MVWEGLNVVKTGR
  • SGPVVAMV
  • PGTIRGD
  • RFEQKGF
  • HYIDLKDRPF
  • PVVAMVWEG
  • PFFPGLV

Post-translational modifications for NME2P1 Gene

No Post-translational modifications

Domains & Families for NME2P1 Gene

Protein Domains for NME2P1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NME2P1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60361

UniProtKB/Swiss-Prot:

NDK8_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2P1: view

No data available for Gene Families for NME2P1 Gene

Function for NME2P1 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for NME2P1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Enzyme Numbers (IUBMB) for NME2P1 Gene

Gene Ontology (GO) - Molecular Function for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity TAS --
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME2P1: view

Phenotypes for NME2P1 Gene

GenomeRNAi human phenotypes for NME2P1:
genes like me logo Genes that share phenotypes with NME2P1: view

Animal Model Products

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No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME2P1 Gene

Localization for NME2P1 Gene

Gene Ontology (GO) - Cellular Components for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with NME2P1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NME2P1 Gene

Pathways & Interactions for NME2P1 Gene

genes like me logo Genes that share pathways with NME2P1: view

Interacting Proteins for NME2P1 Gene

Selected Interacting proteins: O60361-NDK8_HUMAN for NME2P1 Gene via IID

Gene Ontology (GO) - Biological Process for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0015949 nucleobase-containing small molecule interconversion TAS --
genes like me logo Genes that share ontologies with NME2P1: view

No data available for SIGNOR curated interactions for NME2P1 Gene

Drugs & Compounds for NME2P1 Gene

Products:

  1. Drug

(6) Drugs for NME2P1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for NME2P1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
 Full agonist, Agonist 58-64-0
dTDP
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • dTDP
  • TDP
  • Thymidine 5'-diphosphate
 491-97-4
Thymidine 5'-triphosphate
  • 2'-Deoxythymidine 5'-triphosphate
  • 2'-Deoxythymidine triphosphate
  • 5'-TTP
  • 5-Methyl-dUTP
  • Deoxy-TTP
 365-08-2
genes like me logo Genes that share compounds with NME2P1: view

Transcripts for NME2P1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for NME2P1 Gene

(10) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME2P1 Gene

No ASD Table

Relevant External Links for NME2P1 Gene

GeneLoc Exon Structure for
NME2P1
ECgene alternative splicing isoforms for
NME2P1

Expression for NME2P1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME2P1 Gene

mRNA expression in normal human tissues for NME2P1 Gene
mRNA expression by GTEx for NME2P1 Gene

mRNA differential expression in normal tissues according to GTEx for NME2P1 Gene

This gene is overexpressed in Pancreas (x6.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for NME2P1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Peripheral blood mononuclear cells (8.3), Tlymphocyte (8.3), Monocytes (7.8), Brain (6.3), and Cervix (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NME2P1 Gene



NURSA nuclear receptor signaling pathways regulating expression of NME2P1 Gene:

NME2P1
genes like me logo Genes that share expression patterns with NME2P1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME2P1 Gene

Orthologs for NME2P1 Gene

Evolution for NME2P1 Gene

ENSEMBL:
Gene Tree for NME2P1 (if available)
TreeFam:
Gene Tree for NME2P1 (if available)

No data available for Orthologs for NME2P1 Gene

Paralogs for NME2P1 Gene

(8) SIMAP similar genes for NME2P1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NME2P1: view

No data available for Paralogs for NME2P1 Gene

Variants for NME2P1 Gene

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  1. SNP Genotyping and Copy Number Assay

Additional Variant Information for NME2P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME2P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NME2P1 Gene

Disorders for NME2P1 Gene

No disorders were found for NME2P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for NME2P1 Gene

Publications for NME2P1 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58
  5. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. (PMID: 22304920) Lau E … Ronai ZA (Cell 2012) 3 58

Products for NME2P1 Gene

Sources for NME2P1 Gene

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