Aliases for NME2P1 Gene

Aliases for NME2P1 Gene

  • NME2 Pseudogene 1 2 3
  • NME/NM23 Nucleoside Diphosphate Kinase 2 Pseudogene 1 2 3 5
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In, Pseudogene 1 2 3
  • EC 2.7.4.6 4 51
  • Nucleoside Diphosphate Kinase B-Like Pseudogene 3
  • Putative Nucleoside Diphosphate Kinase 4
  • NDP Kinase 4
  • NME2P1 5
  • NDK 4

External Ids for NME2P1 Gene

Previous GeneCards Identifiers for NME2P1 Gene

  • GC12P119131
  • GC12P119182
  • GC12P120719
  • GC12P117728

Summaries for NME2P1 Gene

GeneCards Summary for NME2P1 Gene

NME2P1 (NME2 Pseudogene 1) is a Pseudogene. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and ATP/ITP metabolism. Gene Ontology (GO) annotations related to this gene include nucleoside diphosphate kinase activity.

UniProtKB/Swiss-Prot Summary for NME2P1 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Additional gene information for NME2P1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NME2P1 Gene

Genomics for NME2P1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NME2P1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J120282 Enhancer 0.7 Ensembl ENCODE 600.7 +1.0 1017 2.1 TEAD4 ZNF512 PKNOX1 ZNF341 ZSCAN29 ZBTB40 ZBTB33 L3MBTL2 SP1 NME2P1 lnc-PXN-1 SIRT4 lnc-SIRT4-3 RF00017-1306 PXN RF00017-1304
GH12J120290 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 6.5 +9.9 9940 3.5 ARHGAP35 SP1 HNRNPL CREB1 GATAD2A ATF7 TEAD4 PRDM10 REST ZNF629 SIRT4 RNU4-1 RNU4-2 GCN1 RPL31P52 RAB35 SRSF9 PXN PXN-AS1 RPLP0
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NME2P1 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the NME2P1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • STAT3

Genomic Locations for NME2P1 Gene

Genomic Locations for NME2P1 Gene
chr12:120,282,218-120,282,856
(GRCh38/hg38)
Size:
639 bases
Orientation:
Plus strand
chr12:120,719,940-120,720,668
(GRCh37/hg19)
Size:
729 bases
Orientation:
Plus strand

Genomic View for NME2P1 Gene

Genes around NME2P1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2P1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2P1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2P1 Gene

Proteins for NME2P1 Gene

  • Protein details for NME2P1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60361-NDK8_HUMAN
    Recommended name:
    Putative nucleoside diphosphate kinase
    Protein Accession:
    O60361

    Protein attributes for NME2P1 Gene

    Size:
    137 amino acids
    Molecular mass:
    15529 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NME2P1 Gene

Selected DME Specific Peptides for NME2P1 Gene

O60361:
  • MLGETNPADSKPG
  • NIIHGSD
  • MVWEGLNVVKTGR
  • SGPVVAMV
  • PGTIRGD
  • RFEQKGF
  • HYIDLKDRPF
  • PVVAMVWEG
  • PFFPGLV

Post-translational modifications for NME2P1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NME2P1 Gene

Protein Domains for NME2P1 Gene

InterPro:
Blocks:
  • Nucleoside diphosphate kinase
ProtoNet:

Suggested Antigen Peptide Sequences for NME2P1 Gene

GenScript: Design optimal peptide antigens:
  • Putative nucleoside diphosphate kinase (NDK8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O60361

UniProtKB/Swiss-Prot:

NDK8_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2P1: view

No data available for Gene Families for NME2P1 Gene

Function for NME2P1 Gene

Molecular function for NME2P1 Gene

UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10030};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:18113, ChEBI:CHEBI:30616, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence={ECO:0000255|PROSITE-ProRule:PRU10030};.

Enzyme Numbers (IUBMB) for NME2P1 Gene

Phenotypes From GWAS Catalog for NME2P1 Gene

Gene Ontology (GO) - Molecular Function for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IBA 21873635
GO:0005524 ATP binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with NME2P1: view

Phenotypes for NME2P1 Gene

genes like me logo Genes that share phenotypes with NME2P1: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NME2P1 Gene

Localization for NME2P1 Gene

Gene Ontology (GO) - Cellular Components for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with NME2P1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for NME2P1 Gene

Pathways & Interactions for NME2P1 Gene

genes like me logo Genes that share pathways with NME2P1: view

Pathways by source for NME2P1 Gene

Interacting Proteins for NME2P1 Gene

Selected Interacting proteins: O60361-NDK8_HUMAN for NME2P1 Gene via IID

Gene Ontology (GO) - Biological Process for NME2P1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0042981 regulation of apoptotic process IBA 21873635
genes like me logo Genes that share ontologies with NME2P1: view

No data available for SIGNOR curated interactions for NME2P1 Gene

Drugs & Compounds for NME2P1 Gene

(7) Drugs for NME2P1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
CDP Experimental Pharma 0
Cytidine triphosphate Experimental Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for NME2P1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
dTDP
  • 2'-Deoxyribosylthymine 5'-(trihydrogen diphosphate)
  • Deoxy-TDP
  • Deoxythymidine 5'-diphosphate
  • Thymidine 5'-diphosphate
  • Thymidine 5'-pyrophosphate
491-97-4
genes like me logo Genes that share compounds with NME2P1: view

Transcripts for NME2P1 Gene

mRNA/cDNA for NME2P1 Gene

1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME2P1 Gene

No ASD Table

Relevant External Links for NME2P1 Gene

GeneLoc Exon Structure for
NME2P1

Expression for NME2P1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NME2P1 Gene

mRNA differential expression in normal tissues according to GTEx for NME2P1 Gene

This gene is overexpressed in Pancreas (x6.3) and Testis (x5.2).

Protein differential expression in normal tissues from HIPED for NME2P1 Gene

This gene is overexpressed in Nasal epithelium (14.1), Peripheral blood mononuclear cells (8.3), Tlymphocyte (8.3), Monocytes (7.8), Brain (6.3), and Cervix (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NME2P1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NME2P1

genes like me logo Genes that share expression patterns with NME2P1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME2P1 Gene

Orthologs for NME2P1 Gene

Evolution for NME2P1 Gene

ENSEMBL:
Gene Tree for NME2P1 (if available)
TreeFam:
Gene Tree for NME2P1 (if available)

No data available for Orthologs for NME2P1 Gene

Paralogs for NME2P1 Gene

(8) SIMAP similar genes for NME2P1 Gene using alignment to 1 proteins:

  • NDK8_HUMAN
genes like me logo Genes that share paralogs with NME2P1: view

No data available for Paralogs for NME2P1 Gene

Variants for NME2P1 Gene

Additional Variant Information for NME2P1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME2P1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Additional dbSNP identifiers (rs#s) , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for NME2P1 Gene

Disorders for NME2P1 Gene

Additional Disease Information for NME2P1

No disorders were found for NME2P1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NME2P1 Gene

Publications for NME2P1 Gene

  1. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3
  2. Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. (PMID: 30110629) Raisner R … Gascoigne KE (Cell reports 2018) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair. (PMID: 29229926) Lu H … Bohr VA (Nature communications 2017) 3
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3

Products for NME2P1 Gene

Sources for NME2P1 Gene