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Aliases for NME2 Gene

Aliases for NME2 Gene

  • NME/NM23 Nucleoside Diphosphate Kinase 2 2 3 5
  • Non-Metastatic Cells 2, Protein (NM23B) Expressed In 2 3
  • C-Myc Purine-Binding Transcription Factor PUF 3 4
  • Histidine Protein Kinase NDKB 3 4
  • NDP Kinase B 3 4
  • NM23B 3 4
  • Epididymis Secretory Sperm Binding Protein Li 155an 3
  • Non-Metastatic Cells 2, Protein (NM23) Expressed In 3
  • Nucleoside Diphosphate Kinase B 3
  • Nucleotide Diphosphate Kinase B 3
  • C-Myc Transcription Factor 3
  • HEL-S-155an 3
  • EC 2.7.13.3 4
  • EC 2.7.4.6 4
  • NM23-H2 3
  • Nm23-H2 4
  • NDPK-B 3
  • NDPKB 3
  • NDK B 4
  • NDKB 3
  • PUF 3

External Ids for NME2 Gene

Previous GeneCards Identifiers for NME2 Gene

  • GC17U990063
  • GC17P051725
  • GC17P049584
  • GC17P049718
  • GC17P046598
  • GC17P049242
  • GC17P044612

Summaries for NME2 Gene

Entrez Gene Summary for NME2 Gene

  • Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by NME1) and 'B' (encoded by this gene) isoforms. Multiple alternatively spliced transcript variants have been found for this gene. Read-through transcription from the neighboring upstream gene (NME1) generates naturally-occurring transcripts (NME1-NME2) that encode a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME2 Gene

NME2 (NME/NM23 Nucleoside Diphosphate Kinase 2) is a Protein Coding gene. Diseases associated with NME2 include Nasopharyngeal Carcinoma and Myxosarcoma. Among its related pathways are Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics and Pyrimidine metabolism (KEGG). Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is NME1-NME2.

UniProtKB/Swiss-Prot for NME2 Gene

  • Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.

Gene Wiki entry for NME2 Gene

Additional gene information for NME2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NME2 Gene

Genomics for NME2 Gene

GeneHancer (GH) Regulatory Elements for NME2 Gene

Promoters and enhancers for NME2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J051164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 685.7 +1.2 1247 3.5 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 NME2 UTP18 MBTD1 LUC7L3 EME1 COL1A1 NME1-NME2 ENSG00000279089
GH17J051169 Promoter 0.5 EPDnew 650.7 +4.6 4573 0.1 NME2 NME1-NME2 ENSG00000279089
GH17J051152 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 19.8 -11.8 -11756 2.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NME1 NME1-NME2 MBTD1 LUC7L3 UTP18 COL1A1 EME1 NME2 LOC105371824 CACNA1G-AS1
GH17J050945 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 21.5 -216.2 -216182 6.8 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B NME2 NME1 MBTD1 WFIKKN2 NME1-NME2 COL1A1 ENSG00000251665 ENSG00000247011 ENSG00000249870
GH17J050953 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 18.7 -210.4 -210426 3 ARID4B FEZF1 ZNF2 GLIS2 SP3 REST TSHZ1 ZNF518A NFIL3 ZNF610 NME2 WFIKKN2 NME1 NME1-NME2 ENSG00000251665 ENSG00000247011 ENSG00000249870
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NME2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NME2 gene promoter:
  • AP-1
  • STAT1

Genomic Locations for NME2 Gene

Genomic Locations for NME2 Gene
chr17:51,165,435-51,171,747
(GRCh38/hg38)
Size:
6,313 bases
Orientation:
Plus strand
chr17:49,230,951-49,249,105
(GRCh37/hg19)
Size:
18,155 bases
Orientation:
Plus strand

Genomic View for NME2 Gene

Genes around NME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME2 Gene

Proteins for NME2 Gene

  • Protein details for NME2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22392-NDKB_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase B
    Protein Accession:
    P22392
    Secondary Accessions:
    • A8MWA3
    • Q1WM23
    • Q6LCT6

    Protein attributes for NME2 Gene

    Size:
    152 amino acids
    Molecular mass:
    17298 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8 (By similarity). Interacts with AKAP13. Interacts ITGB1BP1 (via C-terminal domain region).

    Three dimensional structures from OCA and Proteopedia for NME2 Gene

    Alternative splice isoforms for NME2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NME2 Gene

Post-translational modifications for NME2 Gene

  • Ubiquitination at Lys39
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for NME2
  • Boster Bio Antibodies for NME2

No data available for DME Specific Peptides for NME2 Gene

Domains & Families for NME2 Gene

Gene Families for NME2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NME2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22392

UniProtKB/Swiss-Prot:

NDKB_HUMAN :
  • Belongs to the NDK family.
Family:
  • Belongs to the NDK family.
genes like me logo Genes that share domains with NME2: view

Function for NME2 Gene

Molecular function for NME2 Gene

UniProtKB/Swiss-Prot Function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
GENATLAS Biochemistry:
non-metastatic cells 2,protein,with a nm23 nucleoside diphosphate kinase gene family,involved in the phosphorylation of nucleoside diphosphates and acting as a transcription regulator for myc,pyrimidine biosynthetic pathway

Enzyme Numbers (IUBMB) for NME2 Gene

Phenotypes From GWAS Catalog for NME2 Gene

Gene Ontology (GO) - Molecular Function for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 8392752
GO:0004550 nucleoside diphosphate kinase activity EXP,IDA 1851158
GO:0004673 protein histidine kinase activity IEA --
GO:0005515 protein binding IPI 11919189
genes like me logo Genes that share ontologies with NME2: view
genes like me logo Genes that share phenotypes with NME2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NME2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NME2

Clone Products

  • Addgene plasmids for NME2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NME2 Gene

Localization for NME2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NME2 Gene

Cytoplasm. Nucleus. Cell projection, lamellipodium. Cell projection, ruffle. Note=Isoform 3 is mainly cytoplasmic and isoform 1 and isoform 3 are excluded from the nucleolus. Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269 PubMed:11919189, ECO:0000269 PubMed:16442775}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
plasma membrane 2
cytoskeleton 2
mitochondrion 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IDA 11919189
GO:0005576 extracellular region TAS --
GO:0005634 nucleus HDA,IEA 21630459
GO:0005737 cytoplasm IEA,IDA 15703214
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NME2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NME2 Gene

Pathways & Interactions for NME2 Gene

genes like me logo Genes that share pathways with NME2: view

SIGNOR curated interactions for NME2 Gene

Activates:

Gene Ontology (GO) - Biological Process for NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NME2: view

Drugs & Compounds for NME2 Gene

(19) Drugs for NME2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adefovir Dipivoxil Approved, Investigational Pharma Enzyme, substrate 138
Lamivudine Approved, Investigational Pharma Enzyme, substrate Nucleoside analog reverse transcriptase inhibitor 638
Tenofovir disoproxil Approved, Investigational Pharma Enzyme, substrate 0
Magnesium Approved Nutra 0
Guanosine diphosphate Experimental Pharma Target 0

(15) Additional Compounds for NME2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2'-Deoxyinosine triphosphate
  • 2'-Deoxyinosine 5'-triphosphate
  • 2'-Deoxyinosine-5'-triphosphate
  • Deoxyinosine 5'-triphosphate
  • 2'-Deoxyinosine 5'-triphosphoric acid
  • 2'-Deoxyinosine triphosphoric acid
16595-02-1
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
dADP
  • 2'-Deoxyadenosine-5'-diphosphate
  • Deoxyadenosine diphosphate
2793-06-8
dcdp
  • 2'-Deoxycytidine 5'-diphosphate
  • 2'-Deoxycytidine diphosphate
  • D-1beta-Ribofuranosylcytosine diphosphate
  • Deoxycytidine diphosphate
  • 2'-Deoxycytidine 5'-diphosphoric acid
800-73-7
Deoxyuridine triphosphate
  • 2'-Deoxyuridine 5'-triphosphate
  • 2'-Deoxyuridine 5'-triphosphoric acid
  • Deoxyuridine triphosphoric acid
  • 2'-Deoxyuridine-5'-triphosphorate
  • 2'-Deoxyuridine-5'-triphosphoric acid
1173-82-6
genes like me logo Genes that share compounds with NME2: view

Transcripts for NME2 Gene

Unigene Clusters for NME2 Gene

NME/NM23 nucleoside diphosphate kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NME2

Clone Products

  • Addgene plasmids for NME2

Alternative Splicing Database (ASD) splice patterns (SP) for NME2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - - -
SP7:

Relevant External Links for NME2 Gene

GeneLoc Exon Structure for
NME2
ECgene alternative splicing isoforms for
NME2

Expression for NME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NME2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NME2 Gene



Protein tissue co-expression partners for NME2 Gene

NURSA nuclear receptor signaling pathways regulating expression of NME2 Gene:

NME2

SOURCE GeneReport for Unigene cluster for NME2 Gene:

Hs.463456

mRNA Expression by UniProt/SwissProt for NME2 Gene:

P22392-NDKB_HUMAN
Tissue specificity: Isoform 1 and isoform 3 are ubiquitously expressed.

Evidence on tissue expression from TISSUES for NME2 Gene

  • Eye(4)
  • Lymph node(2.3)
genes like me logo Genes that share expression patterns with NME2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME2 Gene

Orthologs for NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm20390 34
  • 97 (a)
ManyToMany
Nme2 16 34 33
  • 90.35 (n)
Gm4862 34
  • 73 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia NME2 34
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia NME2 33
  • 91.67 (n)
cow
(Bos Taurus)
Mammalia NME2 34 33
  • 91.45 (n)
OneToMany
rat
(Rattus norvegicus)
Mammalia Nme2 33
  • 91.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 34
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NME2 34 33
  • 83.89 (n)
ManyToMany
NME1 34
  • 81 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia nme2 33
  • 77.7 (n)
Str.5826 33
zebrafish
(Danio rerio)
Actinopterygii nme2b.2 34 33
  • 75.45 (n)
ManyToMany
nme2a 34
  • 68 (a)
ManyToMany
CABZ01038708.1 34
  • 61 (a)
ManyToMany
-- 33
fruit fly
(Drosophila melanogaster)
Insecta awd 34 35
  • 68 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ndk-1 34
  • 68 (a)
OneToMany
F25H2.5 35
  • 68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 34
  • 60 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.5246 33
rice
(Oryza sativa)
Liliopsida Os07g0492000 33
  • 63.74 (n)
Os.146 33
wheat
(Triticum aestivum)
Liliopsida Ta.4748 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
OneToMany
Species where no ortholog for NME2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for NME2 Gene

ENSEMBL:
Gene Tree for NME2 (if available)
TreeFam:
Gene Tree for NME2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NME2: view image

Paralogs for NME2 Gene

Paralogs for NME2 Gene

(8) SIMAP similar genes for NME2 Gene using alignment to 3 proteins:

  • NDKB_HUMAN
  • J3KPD9_HUMAN
  • Q6FHN3_HUMAN

Pseudogenes.org Pseudogenes for NME2 Gene

genes like me logo Genes that share paralogs with NME2: view

Variants for NME2 Gene

Sequence variations from dbSNP and Humsavar for NME2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000099463 -- 51,164,192(+) A/G upstream_transcript_variant
rs1000321303 -- 51,168,650(+) A/G intron_variant
rs1000422584 -- 51,168,503(+) C/G intron_variant
rs1001811206 -- 51,167,741(+) A/G intron_variant
rs1002267495 -- 51,169,173(+) T/G intron_variant

Variation tolerance for NME2 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NME2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME2 Gene

Disorders for NME2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for NME2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
nasopharyngeal carcinoma
  • npca
myxosarcoma
lung sarcoma
  • pulmonary sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search NME2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NME2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME2 Gene

Publications for NME2 Gene

  1. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution. (PMID: 8747457) Moréra S … Janin J (Structure (London, England : 1993) 1995) 3 4 22 58
  2. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. (PMID: 8392752) Postel EH … Ferrone CA (Science (New York, N.Y.) 1993) 3 4 22 58
  3. Identification of a second human nm23 gene, nm23-H2. (PMID: 1988104) Stahl JA … Steeg PS (Cancer research 1991) 2 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. Nme protein family evolutionary history, a vertebrate perspective. (PMID: 19852809) Desvignes T … Bobe J (BMC evolutionary biology 2009) 2 3 58

Products for NME2 Gene

Sources for NME2 Gene

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