This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010] See more...

Aliases for NME1-NME2 Gene

Aliases for NME1-NME2 Gene

  • NME1-NME2 Readthrough 2 3 5 13
  • NME1-NME2 Readthrough Transcript 3
  • Nucleoside Diphosphate Kinase 13
  • NME1-NME2 Protein 3
  • EC 2.7.4.6 4
  • NM23-LV 3
  • NMELV 3

External Ids for NME1-NME2 Gene

Previous GeneCards Identifiers for NME1-NME2 Gene

  • GC17U900586
  • GC17P046586
  • GC17P049230
  • GC17P044600

Summaries for NME1-NME2 Gene

Entrez Gene Summary for NME1-NME2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for NME1-NME2 Gene

NME1-NME2 (NME1-NME2 Readthrough) is a Protein Coding gene. Diseases associated with NME1-NME2 include Endometrium Carcinoma In Situ and Amelogenesis Imperfecta, Type Ig. Among its related pathways are superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis and purine nucleotides de novo biosynthesis. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein histidine kinase activity. An important paralog of this gene is NME1.

Gene Wiki entry for NME1-NME2 Gene

Additional gene information for NME1-NME2 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NME1-NME2 Gene

Genomics for NME1-NME2 Gene

GeneHancer (GH) Regulatory Elements for NME1-NME2 Gene

Promoters and enhancers for NME1-NME2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NME1-NME2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NME1-NME2

Genomic Locations for NME1-NME2 Gene

Genomic Locations for NME1-NME2 Gene
chr17:51,153,536-51,171,744
(GRCh38/hg38)
Size:
18,209 bases
Orientation:
Plus strand
chr17:49,230,897-49,249,108
(GRCh37/hg19)
Size:
18,212 bases
Orientation:
Plus strand

Genomic View for NME1-NME2 Gene

Genes around NME1-NME2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NME1-NME2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NME1-NME2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NME1-NME2 Gene

Proteins for NME1-NME2 Gene

  • Protein details for NME1-NME2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q32Q12-Q32Q12_HUMAN
    Recommended name:
    Nucleoside diphosphate kinase
    Protein Accession:
    Q32Q12

    Protein attributes for NME1-NME2 Gene

    Size:
    292 amino acids
    Molecular mass:
    32642 Da
    Quaternary structure:
    No Data Available
  • Protein details for NME1-NME2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    J3KPD9-J3KPD9_HUMAN
    Recommended name:
    NME1-NME2 readthrough
    Protein Accession:
    J3KPD9

    Protein attributes for NME1-NME2 Gene

    Size:
    197 amino acids
    Molecular mass:
    22422 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NME1-NME2 Gene

Post-translational modifications for NME1-NME2 Gene

No Post-translational modifications

Other Protein References for NME1-NME2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NME1-NME2 Gene

Domains & Families for NME1-NME2 Gene

Gene Families for NME1-NME2 Gene

Unknown:
  • Belongs to the NDK family.
  • Belongs to the NDK family.
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NME1-NME2 Gene

Suggested Antigen Peptide Sequences for NME1-NME2 Gene

GenScript: Design optimal peptide antigens:
  • Nucleoside diphosphate kinase (F6XY72_HUMAN)
  • Nucleoside diphosphate kinase (Q32Q12_HUMAN)
genes like me logo Genes that share domains with NME1-NME2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NME1-NME2 Gene

Function for NME1-NME2 Gene

Molecular function for NME1-NME2 Gene

UniProtKB/TrEMBL CatalyticActivity:
Reaction=a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP; Xref=Rhea:RHEA:44640, ChEBI:CHEBI:30616, ChEBI:CHEBI:61560, ChEBI:CHEBI:73316, ChEBI:CHEBI:456216; EC=2.7.4.6; Evidence=. ;.
  • Q32Q12

Enzyme Numbers (IUBMB) for NME1-NME2 Gene

Phenotypes From GWAS Catalog for NME1-NME2 Gene

Gene Ontology (GO) - Molecular Function for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004550 nucleoside diphosphate kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with NME1-NME2: view
genes like me logo Genes that share phenotypes with NME1-NME2: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NME1-NME2 Gene

Localization for NME1-NME2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NME1-NME2 gene
Compartment Confidence
cytosol 5
extracellular 4
plasma membrane 3
cytoskeleton 3
mitochondrion 3
nucleus 3
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NME1-NME2 Gene

Pathways & Interactions for NME1-NME2 Gene

genes like me logo Genes that share pathways with NME1-NME2: view

Pathways by source for NME1-NME2 Gene

Interacting Proteins for NME1-NME2 Gene

;

Gene Ontology (GO) - Biological Process for NME1-NME2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006165 nucleoside diphosphate phosphorylation IEA --
GO:0006183 GTP biosynthetic process IEA --
GO:0006228 UTP biosynthetic process IEA --
GO:0006241 CTP biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with NME1-NME2: view

No data available for SIGNOR curated interactions for NME1-NME2 Gene

Drugs & Compounds for NME1-NME2 Gene

No Compound Related Data Available

Transcripts for NME1-NME2 Gene

mRNA/cDNA for NME1-NME2 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NME1-NME2 Gene

No ASD Table

Relevant External Links for NME1-NME2 Gene

GeneLoc Exon Structure for
NME1-NME2

Expression for NME1-NME2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NME1-NME2 Gene

Protein differential expression in normal tissues from HIPED for NME1-NME2 Gene

This gene is overexpressed in Saliva (16.3) and Brain (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB and MOPED for NME1-NME2 Gene



Protein tissue co-expression partners for NME1-NME2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NME1-NME2

Evidence on tissue expression from TISSUES for NME1-NME2 Gene

  • Eye(4.3)
  • Liver(2.4)
  • Blood(2.2)
  • Lung(2.2)
  • Nervous system(2.2)
  • Lymph node(2.1)
  • Heart(2)
genes like me logo Genes that share expression patterns with NME1-NME2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NME1-NME2 Gene

Orthologs for NME1-NME2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NME1-NME2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Nme2 31
  • 97 (a)
ManyToMany
Gm20390 31
  • 97 (a)
ManyToMany
Gm5566 17 30
  • 89.47 (n)
oppossum
(Monodelphis domestica)
Mammalia NME2 31
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC101059613 30
  • 96.35 (n)
-- 31
  • 92 (a)
ManyToMany
-- 31
  • 76 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia NME2 31
  • 96 (a)
OneToMany
LOC101905864 30
  • 74.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NME2 31
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves NME2 31
  • 92 (a)
ManyToMany
NME1 31
  • 81 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nme2b.2 31
  • 78 (a)
ManyToMany
nme2a 31 30
  • 71.36 (n)
ManyToMany
CABZ01038708.1 31
  • 61 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta awd 31 30
  • 69.28 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007120 30
  • 67.5 (n)
worm
(Caenorhabditis elegans)
Secernentea ndk-1 31 30
  • 62.28 (n)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03696g 30
  • 60.96 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR096C 30
  • 59.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YNK1 33 31 30
  • 58.94 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons NDPK1 30
  • 61.01 (n)
rice
(Oryza sativa)
Liliopsida Os10g0563700 30
  • 63.29 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 69 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU04202 30
  • 64.47 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ndk1 30
  • 54.67 (n)
Species where no ortholog for NME1-NME2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NME1-NME2 Gene

ENSEMBL:
Gene Tree for NME1-NME2 (if available)
TreeFam:
Gene Tree for NME1-NME2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NME1-NME2: view image

Paralogs for NME1-NME2 Gene

Paralogs for NME1-NME2 Gene

(6) SIMAP similar genes for NME1-NME2 Gene using alignment to 2 proteins:

  • F6XY72_HUMAN
  • Q32Q12_HUMAN

Pseudogenes.org Pseudogenes for NME1-NME2 Gene

genes like me logo Genes that share paralogs with NME1-NME2: view

Variants for NME1-NME2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NME1-NME2 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
727415 Benign: not provided 51,161,282(+) T/G INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for NME1-NME2 Gene

Variation tolerance for NME1-NME2 Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NME1-NME2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NME1-NME2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for NME1-NME2 Gene

Disorders for NME1-NME2 Gene

MalaCards: The human disease database

(6) MalaCards diseases for NME1-NME2 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NME1-NME2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NME1-NME2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NME1-NME2 Gene

Publications for NME1-NME2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 41 54
  2. Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV. (PMID: 16442775) Valentijn LJ … Versteeg R (Genomics 2006) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones. (PMID: 28515276) Malinová A … Verheggen C (The Journal of cell biology 2017) 3 54
  5. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. (PMID: 28685749) Garzia A … Sonenberg N (Nature communications 2017) 3 54

Products for NME1-NME2 Gene

Sources for NME1-NME2 Gene