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Aliases for NMBR Gene

Aliases for NMBR Gene

  • Neuromedin B Receptor 2 3 5
  • Neuromedin-B-Preferring Bombesin Receptor 3 4
  • Epididymis Tissue Protein Li 185a 3 4
  • Bombesin Receptor 1 2 3
  • NMB-R 3 4
  • Epididymis Secretory Sperm Binding Protein Li 185a 3
  • Neuromedin-B Receptor 3
  • BB1R 3
  • BB1 3

External Ids for NMBR Gene

Previous GeneCards Identifiers for NMBR Gene

  • GC06M142243
  • GC06M142377
  • GC06M142438
  • GC06M139962

Summaries for NMBR Gene

Entrez Gene Summary for NMBR Gene

  • This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GeneCards Summary for NMBR Gene

NMBR (Neuromedin B Receptor) is a Protein Coding gene. Diseases associated with NMBR include Lung Cancer and Small Cell Cancer Of The Lung. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and bombesin receptor activity. An important paralog of this gene is GRPR.

UniProtKB/Swiss-Prot for NMBR Gene

  • Receptor for neuromedin-B.

Tocris Summary for NMBR Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Gene Wiki entry for NMBR Gene

Additional gene information for NMBR Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMBR Gene

Genomics for NMBR Gene

GeneHancer (GH) Regulatory Elements for NMBR Gene

Promoters and enhancers for NMBR Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J142146 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 660.7 -0.2 -184 2 MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC NMBR VTA1 GC06P142170
GH06J142088 Promoter 0.9 EPDnew 650.2 +58.2 58197 0.1 NCOA6 AFF1 NCOA1 SIN3A MIER2 EBF1 REST ZBTB40 EHMT2 NMBR-AS1 NMBR GJE1
GH06J142155 Enhancer 0.8 Ensembl ENCODE 10.3 -8.8 -8826 1.6 CTCF SRF PKNOX1 ZNF654 NANOG EBF1 MEF2B KDM5A ZBTB40 RAD21 NMBR VTA1 GC06P142170
GH06J142259 Enhancer 0.9 ENCODE 7.4 -112.5 -112486 1.1 FOXA2 MLX ZNF48 ETS1 YY1 SLC30A9 NFKBIZ RXRA MIER2 REST GC06P142257 LOC105378032 ADGRG6 NMBR
GH06J142232 Enhancer 1.1 Ensembl ENCODE 4.3 -85.6 -85583 0.6 FOXA2 ARID4B DMAP1 ZNF48 SLC30A9 NFKBIZ SP5 MXD4 MIER2 PPARG GC06P142232 ADGRG6 NMBR GC06P142257
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NMBR on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMBR gene promoter:

Genomic Locations for NMBR Gene

Genomic Locations for NMBR Gene
chr6:142,058,330-142,147,118
(GRCh38/hg38)
Size:
88,789 bases
Orientation:
Minus strand
chr6:142,379,467-142,409,936
(GRCh37/hg19)

Genomic View for NMBR Gene

Genes around NMBR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMBR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMBR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMBR Gene

Proteins for NMBR Gene

  • Protein details for NMBR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28336-NMBR_HUMAN
    Recommended name:
    Neuromedin-B receptor
    Protein Accession:
    P28336
    Secondary Accessions:
    • E9KL38
    • Q5VUK8

    Protein attributes for NMBR Gene

    Size:
    390 amino acids
    Molecular mass:
    43435 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NMBR Gene

Post-translational modifications for NMBR Gene

  • Glycosylation at Asn192, Asn16, and Asn8
  • Modification sites at PhosphoSitePlus

Other Protein References for NMBR Gene

No data available for DME Specific Peptides for NMBR Gene

Domains & Families for NMBR Gene

Gene Families for NMBR Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NMBR Gene

Graphical View of Domain Structure for InterPro Entry

P28336

UniProtKB/Swiss-Prot:

NMBR_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with NMBR: view

Function for NMBR Gene

Molecular function for NMBR Gene

UniProtKB/Swiss-Prot Function:
Receptor for neuromedin-B.
GENATLAS Biochemistry:
neuromedin B receptor, G protein coupled receptor superfamily

Phenotypes From GWAS Catalog for NMBR Gene

Gene Ontology (GO) - Molecular Function for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004946 bombesin receptor activity TAS,IEA --
GO:0008528 G-protein coupled peptide receptor activity IEA --
genes like me logo Genes that share ontologies with NMBR: view
genes like me logo Genes that share phenotypes with NMBR: view

Animal Models for NMBR Gene

MGI Knock Outs for NMBR:

Animal Model Products

Clone Products

  • Addgene plasmids for NMBR
  • R&D Systems cDNA Clones for NMBR (Neuromedin B R/NMBR)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for NMBR Gene

Localization for NMBR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMBR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMBR gene
Compartment Confidence
plasma membrane 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8391296
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NMBR: view

Pathways & Interactions for NMBR Gene

genes like me logo Genes that share pathways with NMBR: view

SIGNOR curated interactions for NMBR Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for NMBR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 7838118
GO:0031989 bombesin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with NMBR: view

Drugs & Compounds for NMBR Gene

(30) Drugs for NMBR Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bombesin Investigational Pharma Full agonist, Agonist Involved in gastrointestinal tract function 9
PD 176252 Pharma Antagonist 0
ranatensin Pharma Full agonist, Agonist 0
BIM 187 Pharma Bombesin/GRP receptor agonist 0
GRP (human) Pharma Endogenous GRP receptor agonist 0

(5) Additional Compounds for NMBR Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
[<sup>125</sup>I]BH-NMB
[D-Phe<sup>6</sup>,beta-Ala<sup>11</sup>,Phe<sup>13</sup>,Nle<sup>14</sup>]bombesin-(6-14)
Full agonist, Agonist
gastrin releasing peptide (14-27) (human)
Full agonist, Agonist
BA 1
183241-31-8

(5) Tocris Compounds for NMBR Gene

Compound Action Cas Number
BA 1 Potent BRS-3 agonist; also NMBR and GRPR agonist 183241-31-8
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9

(11) ApexBio Compounds for NMBR Gene

Compound Action Cas Number
[D-Phe12,Leu14]-Bombesin 108437-88-3
[D-Phe12]-Bombesin 108437-87-2
Alytesin 31078-12-3
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
BIM 189 Bombesin antagonist 142062-55-3
BIM 23042 Antagonist of neuromedin B receptor,selective 111857-96-6
BIM 23127 Antagonist of neuromedin B receptor 160161-61-5
Bombesin 31362-50-2
GRP (human) 93755-85-2
Litorin 55749-97-8
PD 176252 204067-01-6
genes like me logo Genes that share compounds with NMBR: view

Drug Products

Transcripts for NMBR Gene

mRNA/cDNA for NMBR Gene

(17) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(6) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NMBR Gene

Neuromedin B receptor:
Representative Sequences:

Clone Products

  • Addgene plasmids for NMBR
  • R&D Systems cDNA Clones for NMBR (Neuromedin B R/NMBR)

Alternative Splicing Database (ASD) splice patterns (SP) for NMBR Gene

No ASD Table

Relevant External Links for NMBR Gene

GeneLoc Exon Structure for
NMBR
ECgene alternative splicing isoforms for
NMBR

Expression for NMBR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMBR Gene

mRNA differential expression in normal tissues according to GTEx for NMBR Gene

This gene is overexpressed in Testis (x7.3), Brain - Nucleus accumbens (basal ganglia) (x5.9), Brain - Hypothalamus (x4.6), and Brain - Caudate (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for NMBR Gene

This gene is overexpressed in Lung (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NMBR Gene



Protein tissue co-expression partners for NMBR Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NMBR Gene:

NMBR

SOURCE GeneReport for Unigene cluster for NMBR Gene:

Hs.654478

mRNA Expression by UniProt/SwissProt for NMBR Gene:

P28336-NMBR_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for NMBR Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with NMBR: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NMBR Gene

Orthologs for NMBR Gene

This gene was present in the common ancestor of animals.

Orthologs for NMBR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMBR 34 33
  • 99.15 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NMBR 34 33
  • 89.66 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NMBR 34 33
  • 88.97 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nmbr 16 34 33
  • 86.32 (n)
rat
(Rattus norvegicus)
Mammalia Nmbr 33
  • 85.73 (n)
oppossum
(Monodelphis domestica)
Mammalia NMBR 34
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NMBR 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMBR 34 33
  • 73.83 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NMBR 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nmbrl 33
  • 65.01 (n)
nmbr 34
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta GPRGRP1 33
  • 48.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CCHa1r 34 33
  • 46.63 (n)
ManyToMany
CG30106 35
  • 36 (a)
CCHa2r 34
  • 27 (a)
ManyToMany
Species where no ortholog for NMBR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMBR Gene

ENSEMBL:
Gene Tree for NMBR (if available)
TreeFam:
Gene Tree for NMBR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMBR: view image

Paralogs for NMBR Gene

Paralogs for NMBR Gene

(8) SIMAP similar genes for NMBR Gene using alignment to 2 proteins:

  • NMBR_HUMAN
  • Q4VBL0_HUMAN
genes like me logo Genes that share paralogs with NMBR: view

Variants for NMBR Gene

Sequence variations from dbSNP and Humsavar for NMBR Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000062993 -- 142,140,254(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000079733 -- 142,142,879(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000093842 -- 142,139,966(-) G/C genic_upstream_transcript_variant, intron_variant
rs1000126420 -- 142,139,695(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000140638 -- 142,128,394(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NMBR Gene

Variant ID Type Subtype PubMed ID
dgv1835e212 CNV loss 25503493
esv3611073 CNV loss 21293372
nsv1027489 CNV loss 25217958
nsv464069 CNV gain 19166990
nsv604792 CNV loss 21841781
nsv604794 CNV gain 21841781
nsv830824 CNV gain 17160897

Variation tolerance for NMBR Gene

Residual Variation Intolerance Score: 88.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.84; 79.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMBR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMBR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMBR Gene

Disorders for NMBR Gene

MalaCards: The human disease database

(3) MalaCards diseases for NMBR Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • lung cancer, susceptibility to
small cell cancer of the lung
  • sclc1
schizophrenia
  • sczd
- elite association - COSMIC cancer census association via MalaCards
Search NMBR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMBR

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NMBR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMBR Gene

Publications for NMBR Gene

  1. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. (PMID: 1655761) Corjay MH … Battey JF (The Journal of biological chemistry 1991) 3 4 22 58
  2. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J … Liu Y (Molecular & cellular proteomics : MCP 2010) 3 4 58
  3. Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo. (PMID: 21060863) Ikram MK … Wong TY (PLoS genetics 2010) 3 44 58
  4. Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon. (PMID: 15528253) Matusiak D … Benya RV (American journal of physiology. Gastrointestinal and liver physiology 2005) 3 22 58
  5. Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. (PMID: 15634004) Nock BA … Maina T (Journal of medicinal chemistry 2005) 3 22 58

Products for NMBR Gene

Sources for NMBR Gene

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