Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NMB Gene

Aliases for NMB Gene

  • Neuromedin B 2 3 5
  • Neuromedin-B-32 3
  • Neuromedin-Beta 3
  • Neuromedin-B 3

External Ids for NMB Gene

Previous GeneCards Identifiers for NMB Gene

  • GC15M081266
  • GC15P078219
  • GC15M082785
  • GC15M082928
  • GC15M082999
  • GC15M085198
  • GC15M061284

Summaries for NMB Gene

Entrez Gene Summary for NMB Gene

  • This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMB Gene

NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include Gastrinoma and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include hormone activity and neuromedin B receptor binding.

UniProtKB/Swiss-Prot for NMB Gene

  • Stimulates smooth muscle contraction in a manner similar to that of bombesin.

Tocris Summary for NMB Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

Additional gene information for NMB Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NMB Gene

Genomics for NMB Gene

GeneHancer (GH) Regulatory Elements for NMB Gene

Promoters and enhancers for NMB Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I084657 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 594.2 +0.1 65 1.6 ELF3 ARID4B SIN3A DMAP1 ZNF2 KLF5 RAD21 YY1 ZNF335 ZNF143 NMB WDR73
GH15I084746 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 38.3 -90.3 -90289 5.2 HDGF ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 POLR2B ZNF592 GC15M084747 NMB GOLGA6L4 WDR73 GOLGA6L5P SCAND2P GOLGA6L3 UBE2Q2P1 ENSG00000259683
GH15I084714 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 39.6 -57.4 -57390 3.4 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 ZNF548 SP3 SEC11A SCAND2P WDR73 NMB GOLGA6L5P ZNF592 LINC00933 UBE2Q2P1 GOLGA6L4 CSPG4P12
GH15I084652 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 44.5 +4.2 4152 3 HDGF PKNOX1 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 WDR73 NMB SCAND2P RN7SL331P ENSG00000259683
GH15I084597 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 31.4 +58.5 58520 4.3 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZBTB7B YY1 ZNF766 ZNF207 ZNF143 ZSCAN2 GOLGA6L4 NMB GOLGA6L5P SCAND2P WDR73 GOLGA6L3 RN7SL331P LOC101929479 ZNF592
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NMB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NMB gene promoter:

Genomic Locations for NMB Gene

Genomic Locations for NMB Gene
chr15:84,655,129-84,658,571
(GRCh38/hg38)
Size:
3,443 bases
Orientation:
Minus strand
chr15:85,198,360-85,201,802
(GRCh37/hg19)

Genomic View for NMB Gene

Genes around NMB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMB Gene

Proteins for NMB Gene

  • Protein details for NMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08949-NMB_HUMAN
    Recommended name:
    Neuromedin-B
    Protein Accession:
    P08949
    Secondary Accessions:
    • Q96A06
    • Q96HH5

    Protein attributes for NMB Gene

    Size:
    121 amino acids
    Molecular mass:
    13252 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMB Gene

    Alternative splice isoforms for NMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMB Gene

Post-translational modifications for NMB Gene

  • Glycosylation at isoforms=252 and Ser60
  • Modification sites at PhosphoSitePlus

Other Protein References for NMB Gene

No data available for DME Specific Peptides for NMB Gene

Domains & Families for NMB Gene

Gene Families for NMB Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NMB Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NMB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08949

UniProtKB/Swiss-Prot:

NMB_HUMAN :
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
Family:
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
genes like me logo Genes that share domains with NMB: view

Function for NMB Gene

Molecular function for NMB Gene

GENATLAS Biochemistry:
neuromedin B
UniProtKB/Swiss-Prot Function:
Stimulates smooth muscle contraction in a manner similar to that of bombesin.

Phenotypes From GWAS Catalog for NMB Gene

Gene Ontology (GO) - Molecular Function for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 2458345
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NMB: view

Phenotypes for NMB Gene

genes like me logo Genes that share phenotypes with NMB: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NMB

CRISPR Products

miRNA for NMB Gene

miRTarBase miRNAs that target NMB

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NMB Gene

Localization for NMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMB gene
Compartment Confidence
extracellular 5
nucleus 3
plasma membrane 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with NMB: view

Pathways & Interactions for NMB Gene

genes like me logo Genes that share pathways with NMB: view

SIGNOR curated interactions for NMB Gene

Activates:

Gene Ontology (GO) - Biological Process for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2458345
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007267 cell-cell signaling TAS 2458345
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with NMB: view

Drugs & Compounds for NMB Gene

(19) Drugs for NMB Gene - From: ClinicalTrials, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neostigmine Approved, Vet_approved Pharma 122
Bombesin Investigational Pharma Full agonist, Agonist Involved in gastrointestinal tract function 9
Autonomic Agents Pharma 10732
Cholinergic Agents Pharma 4186
Cholinesterase Inhibitors Pharma 617

(4) Additional Compounds for NMB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for NMB Gene

Compound Action Cas Number
BA 1 Potent BRS-3 agonist; also NMBR and GRPR agonist 183241-31-8
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9

(1) ApexBio Compounds for NMB Gene

Compound Action Cas Number
Neuromedin B (porcine) 87096-84-2
genes like me logo Genes that share compounds with NMB: view

Drug Products

Transcripts for NMB Gene

mRNA/cDNA for NMB Gene

Unigene Clusters for NMB Gene

Neuromedin B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NMB Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NMB Gene

GeneLoc Exon Structure for
NMB
ECgene alternative splicing isoforms for
NMB

Expression for NMB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMB Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.7).

Protein differential expression in normal tissues from HIPED for NMB Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NMB Gene



Protein tissue co-expression partners for NMB Gene

NURSA nuclear receptor signaling pathways regulating expression of NMB Gene:

NMB

SOURCE GeneReport for Unigene cluster for NMB Gene:

Hs.386470

Evidence on tissue expression from TISSUES for NMB Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with NMB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMB Gene

Orthologs for NMB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NMB 33 34
  • 98.9 (n)
cow
(Bos Taurus)
Mammalia NMB 33 34
  • 86.23 (n)
dog
(Canis familiaris)
Mammalia NMB 33 34
  • 84.23 (n)
mouse
(Mus musculus)
Mammalia Nmb 33 16 34
  • 82.09 (n)
rat
(Rattus norvegicus)
Mammalia Nmb 33
  • 80.87 (n)
oppossum
(Monodelphis domestica)
Mammalia NMB 34
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves NMB 34
  • 33 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nmba 34
  • 28 (a)
OneToMany
nmbb 34
  • 26 (a)
OneToMany
Species where no ortholog for NMB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NMB Gene

ENSEMBL:
Gene Tree for NMB (if available)
TreeFam:
Gene Tree for NMB (if available)

Paralogs for NMB Gene

No data available for Paralogs for NMB Gene

Variants for NMB Gene

Sequence variations from dbSNP and Humsavar for NMB Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000982676 -- 84,657,627(-) G/A coding_sequence_variant, intron_variant, stop_gained
rs1001374579 -- 84,659,832(-) C/A/T upstream_transcript_variant
rs1003172401 -- 84,659,551(-) T/A upstream_transcript_variant
rs1003662221 -- 84,658,315(-) G/C/T 5_prime_UTR_variant
rs1003729418 -- 84,659,721(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NMB Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV deletion 23128226
esv3637095 CNV gain 21293372
esv3637097 CNV gain 21293372
nsv428310 CNV gain+loss 18775914
nsv515983 CNV loss 19592680

Variation tolerance for NMB Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMB Gene

Human Gene Mutation Database (HGMD)
NMB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMB

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMB Gene

Disorders for NMB Gene

MalaCards: The human disease database

(4) MalaCards diseases for NMB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastrinoma
  • gastrin cell tumour
neuronal ceroid lipofuscinosis
  • batten disease
lung cancer
  • lung cancer, susceptibility to
small cell cancer of the lung
  • sclc1
- elite association - COSMIC cancer census association via MalaCards
Search NMB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMB

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NMB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMB Gene

Publications for NMB Gene

  1. Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. (PMID: 20010906) Pigeyre M … HELENA Study group (International journal of obesity (2005) 2010) 3 22 44 58
  2. Neuromedin beta: P73T polymorphism in overweight and obese subjects. (PMID: 18271693) Spálová J … Hainer V (Physiological research 2008) 3 22 44 58
  3. Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. (PMID: 11194934) Oeffner F … Grzeschik KH (Acta diabetologica 2000) 3 22 44 58
  4. Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. (PMID: 10544247) Lee S … Kim Y (FEBS letters 1999) 3 4 22 58
  5. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. (PMID: 2458345) Krane IM … Spindel ER (The Journal of biological chemistry 1988) 2 3 4 58

Products for NMB Gene

Sources for NMB Gene

Content
Loading form....