This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multipl... See more...

Aliases for NMB Gene

Aliases for NMB Gene

  • Neuromedin B 2 3 5
  • Neuromedin-B 3 4
  • Neuromedin-B-32 3
  • Neuromedin-Beta 3
  • MGC17211 2
  • MGC2277 2
  • MGC3936 2
  • NMB 5

External Ids for NMB Gene

Previous GeneCards Identifiers for NMB Gene

  • GC15M081266
  • GC15P078219
  • GC15M082785
  • GC15M082928
  • GC15M082999
  • GC15M085198
  • GC15M061284

Summaries for NMB Gene

Entrez Gene Summary for NMB Gene

  • This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for NMB Gene

NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include Gastrinoma and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuromedin B receptor binding. An important paralog of this gene is GRP.

UniProtKB/Swiss-Prot Summary for NMB Gene

  • Stimulates smooth muscle contraction in a manner similar to that of bombesin.

Tocris Summary for NMB Gene

  • Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NMB Gene

Genomics for NMB Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NMB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NMB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NMB

Top Transcription factor binding sites by QIAGEN in the NMB gene promoter:
  • C/EBPbeta
  • FOXO4
  • GR
  • GR-alpha
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3

Genomic Locations for NMB Gene

Latest Assembly
chr15:84,655,129-84,658,611
(GRCh38/hg38)
Size:
3,483 bases
Orientation:
Minus strand

Previous Assembly
chr15:85,198,363-85,201,430
(GRCh37/hg19 by Entrez Gene)
Size:
3,068 bases
Orientation:
Minus strand

chr15:85,198,360-85,201,794
(GRCh37/hg19 by Ensembl)
Size:
3,435 bases
Orientation:
Minus strand

Genomic View for NMB Gene

Genes around NMB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NMB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NMB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NMB Gene

Proteins for NMB Gene

  • Protein details for NMB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08949-NMB_HUMAN
    Recommended name:
    Neuromedin-B
    Protein Accession:
    P08949
    Secondary Accessions:
    • Q96A06
    • Q96HH5

    Protein attributes for NMB Gene

    Size:
    121 amino acids
    Molecular mass:
    13252 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NMB Gene

    Alternative splice isoforms for NMB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NMB Gene

Post-translational modifications for NMB Gene

  • Glycosylation at Thr52, Ser60, Ser64, Ser65, Ser67, Thr71, Thr75, and Ser76
  • Modification sites at PhosphoSitePlus

Other Protein References for NMB Gene

No data available for DME Specific Peptides for NMB Gene

Domains & Families for NMB Gene

Gene Families for NMB Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for NMB Gene

InterPro:
Blocks:
  • Bombesin-like peptide

Suggested Antigen Peptide Sequences for NMB Gene

GenScript: Design optimal peptide antigens:
  • Neuromedin-B (NMB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08949

UniProtKB/Swiss-Prot:

NMB_HUMAN :
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
Family:
  • Belongs to the bombesin/neuromedin-B/ranatensin family.
genes like me logo Genes that share domains with NMB: view

Function for NMB Gene

Molecular function for NMB Gene

UniProtKB/Swiss-Prot Function:
Stimulates smooth muscle contraction in a manner similar to that of bombesin.
GENATLAS Biochemistry:
neuromedin B

Phenotypes From GWAS Catalog for NMB Gene

Gene Ontology (GO) - Molecular Function for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity TAS 2458345
GO:0005184 neuropeptide hormone activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0031710 neuromedin B receptor binding IBA 21873635
genes like me logo Genes that share ontologies with NMB: view
genes like me logo Genes that share phenotypes with NMB: view

Animal Models for NMB Gene

MGI Knock Outs for NMB:
  • Nmb Nmb<tm1.1(KOMP)Vlcg>
  • Nmb Nmb<tm1Zfc>

Animal Models for research

  • Taconic Biosciences Mouse Models for NMB

miRNA for NMB Gene

miRTarBase miRNAs that target NMB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NMB Gene

Localization for NMB Gene

Subcellular locations from UniProtKB/Swiss-Prot for NMB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NMB gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 3
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0043005 neuron projection IEA,IBA 21873635
genes like me logo Genes that share ontologies with NMB: view

Pathways & Interactions for NMB Gene

genes like me logo Genes that share pathways with NMB: view

SIGNOR curated interactions for NMB Gene

Activates:

Gene Ontology (GO) - Biological Process for NMB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 2458345
GO:0007186 G protein-coupled receptor signaling pathway TAS --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007267 cell-cell signaling TAS 2458345
genes like me logo Genes that share ontologies with NMB: view

Drugs & Compounds for NMB Gene

(18) Drugs for NMB Gene - From: ClinicalTrials, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Neostigmine Approved, Vet_approved Pharma 191
Bombesin Investigational Pharma Involved in gastrointestinal tract function 17
Cholinergic Agents Pharma 3956
Cholinesterase Inhibitors Pharma 703
Neurotransmitter Agents Pharma 20509

(4) Additional Compounds for NMB Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
BA 1
183241-31-8

(5) Tocris Compounds for NMB Gene

Compound Action Cas Number
BA 1 Potent BRS-3 agonist; also NMBR and GRPR agonist 183241-31-8
BIM 187 Bombesin/GRP receptor agonist 137734-88-4
Bombesin Involved in gastrointestinal tract function 31362-50-2
GRP (human) Endogenous GRP receptor agonist 93755-85-2
GRP (porcine) Endogenous GRP receptor agonist 74815-57-9

(1) ApexBio Compounds for NMB Gene

Compound Action Cas Number
Neuromedin B (porcine) 87096-84-2
genes like me logo Genes that share compounds with NMB: view

Drug products for research

Transcripts for NMB Gene

mRNA/cDNA for NMB Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NMB

Alternative Splicing Database (ASD) splice patterns (SP) for NMB Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:

Relevant External Links for NMB Gene

GeneLoc Exon Structure for
NMB

Expression for NMB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NMB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NMB Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.7).

Protein differential expression in normal tissues from HIPED for NMB Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NMB Gene



Protein tissue co-expression partners for NMB Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NMB

SOURCE GeneReport for Unigene cluster for NMB Gene:

Hs.386470

Evidence on tissue expression from TISSUES for NMB Gene

  • Nervous system(4.5)
  • Lung(2)
genes like me logo Genes that share expression patterns with NMB: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NMB Gene

Orthologs for NMB Gene

This gene was present in the common ancestor of chordates.

Orthologs for NMB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NMB 29 30
  • 98.9 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NMB 29 30
  • 86.23 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NMB 29 30
  • 84.23 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nmb 29 16 30
  • 82.09 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nmb 29
  • 80.87 (n)
Oppossum
(Monodelphis domestica)
Mammalia NMB 30
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NMB 30
  • 33 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii nmba 30
  • 28 (a)
OneToMany
nmbb 30
  • 26 (a)
OneToMany
Species where no ortholog for NMB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NMB Gene

ENSEMBL:
Gene Tree for NMB (if available)
TreeFam:
Gene Tree for NMB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NMB: view image
Alliance of Genome Resources:
Additional Orthologs for NMB

Paralogs for NMB Gene

Paralogs for NMB Gene

genes like me logo Genes that share paralogs with NMB: view

Variants for NMB Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NMB Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs1051168 -- p.Pro73Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NMB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NMB Gene

Variant ID Type Subtype PubMed ID
esv2672879 CNV deletion 23128226
esv3637095 CNV gain 21293372
esv3637097 CNV gain 21293372
nsv428310 CNV gain+loss 18775914
nsv515983 CNV loss 19592680

Variation tolerance for NMB Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.34; 76.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NMB Gene

Human Gene Mutation Database (HGMD)
NMB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NMB
Leiden Open Variation Database (LOVD)
NMB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NMB Gene

Disorders for NMB Gene

MalaCards: The human disease database

(5) MalaCards diseases for NMB Gene - From: COP and GCD

Disorder Aliases PubMed IDs
gastrinoma
  • gastrin cell tumour
neuronal ceroid lipofuscinosis
  • hereditary ceroid lipofuscinosis
lung cancer
  • lung cancer, susceptibility to
prader-willi syndrome
  • pws
body mass index quantitative trait locus 11
  • bmiq11
- elite association - COSMIC cancer census association via MalaCards
Search NMB in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NMB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with NMB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NMB Gene

Publications for NMB Gene

  1. Influence of maternal educational level on the association between the rs3809508 neuromedin B gene polymorphism and the risk of obesity in the HELENA study. (PMID: 20010906) Pigeyre M … HELENA Study group (International journal of obesity (2005) 2010) 3 22 40
  2. Neuromedin beta: P73T polymorphism in overweight and obese subjects. (PMID: 18271693) Spálová J … Hainer V (Physiological research 2008) 3 22 40
  3. Significant association between a silent polymorphism in the neuromedin B gene and body weight in German children and adolescents. (PMID: 11194934) Oeffner F … Grzeschik KH (Acta diabetologica 2000) 3 22 40
  4. Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy. (PMID: 10544247) Lee S … Kim Y (FEBS letters 1999) 3 4 22
  5. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. (PMID: 2458345) Krane IM … Spindel ER (The Journal of biological chemistry 1988) 2 3 4

Products for NMB Gene

Sources for NMB Gene