Aliases for NMB Gene
External Ids for NMB Gene
Previous GeneCards Identifiers for NMB Gene
This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for NMB Gene
NMB (Neuromedin B) is a Protein Coding gene. Diseases associated with NMB include Gastrinoma and Neuronal Ceroid Lipofuscinosis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuromedin B receptor binding. An important paralog of this gene is GRP.
UniProtKB/Swiss-Prot Summary for NMB Gene
Stimulates smooth muscle contraction in a manner similar to that of bombesin.
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB1, BB2 and an orphan receptor (bb3).