Aliases for NLRX1 Gene
- NLR Family Member X1 2 3 4 5
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing X1 2 3
- Nucleotide-Binding Oligomerization Domain Protein 26 3 4
- Nucleotide-Binding Oligomerization Domain Protein 5 3 4
- Nucleotide-Binding Oligomerization Domain Protein 9 3 4
- Caterpiller Protein 11.3 3 4
External Ids for NLRX1 Gene
Previous GeneCards Identifiers for NLRX1 Gene
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for NLRX1 Gene
NLRX1 (NLR Family Member X1) is a Protein Coding gene. Diseases associated with NLRX1 include Influenza and Mitochondrial Complex V Deficiency, Nuclear Type 3. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and Innate Immune System. An important paralog of this gene is NLRP1.
UniProtKB/Swiss-Prot Summary for NLRX1 Gene
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (PubMed:22749352). Regulates also MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (PubMed:27393910). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).