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Aliases for NLRX1 Gene

Aliases for NLRX1 Gene

  • NLR Family Member X1 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat Containing X1 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 26 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 5 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 9 3 4
  • Caterpiller Protein 11.3 3 4
  • NOD-Like Receptor X1 2 3
  • CLR11.3 3 4
  • NOD26 3 4
  • NOD5 3 4
  • NOD9 3 4
  • NLR Family, X1 2
  • DLNB26 3

External Ids for NLRX1 Gene

Previous GeneCards Identifiers for NLRX1 Gene

  • GC11P118545
  • GC11P119037
  • GC11P114978

Summaries for NLRX1 Gene

Entrez Gene Summary for NLRX1 Gene

  • The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for NLRX1 Gene

NLRX1 (NLR Family Member X1) is a Protein Coding gene. Among its related pathways are Toll-like receptor signaling pathway and Innate Immune System. An important paralog of this gene is NOD2.

UniProtKB/Swiss-Prot for NLRX1 Gene

  • Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Gene Wiki entry for NLRX1 Gene

Additional gene information for NLRX1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRX1 Gene

Genomics for NLRX1 Gene

GeneHancer (GH) Regulatory Elements for NLRX1 Gene

Promoters and enhancers for NLRX1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I119167 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.1 +2.4 2360 2.8 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF213 ZNF207 NLRX1 HINFP GC11M119170
GH11I119166 Enhancer 0.7 Ensembl ENCODE 550.8 +0.1 68 0.3 ZFHX2 JUND RFX1 POLR2A EGR1 FOS TEAD3 NLRX1 GC11M119170
GH11I119100 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 18 -64.4 -64401 3.9 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 C2CD2L DPAGT1 HINFP NLRX1 ABCG4 HMBS H2AFX
GH11I119360 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.4 +196.4 196422 5.8 PKNOX1 FOXA2 SIN3A FEZF1 YY1 GLIS2 FOS RXRA JUNB REST USP2 RNF26 ENSG00000245385 THY1 ABCG4 NLRX1 LOC101929089 GC11M119369 C1QTNF5 MFRP
GH11I119066 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.4 -98.9 -98882 2.2 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 VPS11 ENSG00000272186 DPAGT1 HMBS ARCN1 H2AFX C2CD2L KMT2A ENSG00000254909 SLC37A4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NLRX1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NLRX1 gene promoter:

Genomic Locations for NLRX1 Gene

Genomic Locations for NLRX1 Gene
chr11:119,166,568-119,184,016
(GRCh38/hg38)
Size:
17,449 bases
Orientation:
Plus strand
chr11:119,037,277-119,054,725
(GRCh37/hg19)

Genomic View for NLRX1 Gene

Genes around NLRX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRX1 Gene

Proteins for NLRX1 Gene

  • Protein details for NLRX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UT6-NLRX1_HUMAN
    Recommended name:
    NLR family member X1
    Protein Accession:
    Q86UT6
    Secondary Accessions:
    • A8K6Q1
    • B3KPK2
    • B3KTA2
    • Q7RTR3
    • Q96D51
    • Q9H724

    Protein attributes for NLRX1 Gene

    Size:
    975 amino acids
    Molecular mass:
    107616 Da
    Quaternary structure:
    • Homohexamer. Interacts with MAVS.
    SequenceCaution:
    • Sequence=BAB15075.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG51714.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG51714.1; Type=Erroneous termination; Positions=951; Note=Translated as Trp.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NLRX1 Gene

    Alternative splice isoforms for NLRX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRX1 Gene

Post-translational modifications for NLRX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLRX1 Gene

Domains & Families for NLRX1 Gene

Gene Families for NLRX1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NLRX1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NLRX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UT6

UniProtKB/Swiss-Prot:

NLRX1_HUMAN :
  • The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.
  • Belongs to the NLRP family.
Domain:
  • The LRRCT domain mediates homodimerization and LRRNT mediates trimerization of the dimers.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRX1: view

Function for NLRX1 Gene

Molecular function for NLRX1 Gene

UniProtKB/Swiss-Prot Function:
Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Phenotypes From GWAS Catalog for NLRX1 Gene

Gene Ontology (GO) - Molecular Function for NLRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRX1: view
genes like me logo Genes that share phenotypes with NLRX1: view

Animal Models for NLRX1 Gene

MGI Knock Outs for NLRX1:

miRNA for NLRX1 Gene

miRTarBase miRNAs that target NLRX1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRX1 Gene

Localization for NLRX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRX1 Gene

Mitochondrion outer membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRX1 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Cell Junctions (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NLRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with NLRX1: view

Pathways & Interactions for NLRX1 Gene

genes like me logo Genes that share pathways with NLRX1: view

Pathways by source for NLRX1 Gene

1 R&D Systems pathway for NLRX1 Gene
1 Cell Signaling Technology pathway for NLRX1 Gene

Gene Ontology (GO) - Biological Process for NLRX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0016032 viral process IEA --
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032688 negative regulation of interferon-beta production IEA --
GO:0032715 negative regulation of interleukin-6 production IEA --
genes like me logo Genes that share ontologies with NLRX1: view

No data available for SIGNOR curated interactions for NLRX1 Gene

Drugs & Compounds for NLRX1 Gene

No Compound Related Data Available

Transcripts for NLRX1 Gene

Unigene Clusters for NLRX1 Gene

NLR family member X1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRX1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - -
SP6: - -
SP7: -
SP8:
SP9: - -
SP10: - - - -
SP11: - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - -
SP13:
SP14:

ExUns: 8h ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14: -

Relevant External Links for NLRX1 Gene

GeneLoc Exon Structure for
NLRX1
ECgene alternative splicing isoforms for
NLRX1

Expression for NLRX1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRX1 Gene

mRNA differential expression in normal tissues according to GTEx for NLRX1 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for NLRX1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.1), Urine (9.2), and Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NLRX1 Gene



Protein tissue co-expression partners for NLRX1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NLRX1 Gene:

NLRX1

SOURCE GeneReport for Unigene cluster for NLRX1 Gene:

Hs.524082

mRNA Expression by UniProt/SwissProt for NLRX1 Gene:

Q86UT6-NLRX1_HUMAN
Tissue specificity: Ubiquitously expressed. Strongest expression in mammary gland, heart and muscle. Detected in HeLa, HEK293T, THP-1, HL-60, Raji and Jurkat cell lines (at protein level).

Evidence on tissue expression from TISSUES for NLRX1 Gene

  • Nervous system(4.2)
  • Intestine(4.1)
  • Bone(4)
genes like me logo Genes that share expression patterns with NLRX1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRX1 Gene

Orthologs for NLRX1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRX1 33 34
  • 98.87 (n)
cow
(Bos Taurus)
Mammalia NLRX1 33 34
  • 88.25 (n)
dog
(Canis familiaris)
Mammalia NLRX1 33 34
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Nlrx1 33 16 34
  • 86.72 (n)
rat
(Rattus norvegicus)
Mammalia Nlrx1 33
  • 86.17 (n)
oppossum
(Monodelphis domestica)
Mammalia NLRX1 34
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRX1 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC419755 33
  • 66.3 (n)
NLRX1 34
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLRX1 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrx1 33
  • 58.2 (n)
zebrafish
(Danio rerio)
Actinopterygii nlrx1 33 34
  • 54.26 (n)
Species where no ortholog for NLRX1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRX1 Gene

ENSEMBL:
Gene Tree for NLRX1 (if available)
TreeFam:
Gene Tree for NLRX1 (if available)

Paralogs for NLRX1 Gene

Paralogs for NLRX1 Gene

genes like me logo Genes that share paralogs with NLRX1: view

Variants for NLRX1 Gene

Sequence variations from dbSNP and Humsavar for NLRX1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs530058063 likely-benign, Long QT syndrome 119,180,273(+) G/A coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs199476026 not-provided, not provided 119,168,034(+) G/A upstream_transcript_variant
rs199476027 not-provided, not provided 119,168,321(+) G/A upstream_transcript_variant
rs199476028 not-provided, not provided 119,168,342(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs199476029 not-provided, not provided 119,168,442(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NLRX1 Gene

Variant ID Type Subtype PubMed ID
nsv468879 CNV loss 19166990
nsv556466 CNV loss 21841781
nsv556467 CNV loss 21841781

Variation tolerance for NLRX1 Gene

Residual Variation Intolerance Score: 96.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLRX1 Gene

Human Gene Mutation Database (HGMD)
NLRX1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRX1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRX1 Gene

Disorders for NLRX1 Gene

Additional Disease Information for NLRX1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NLRX1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRX1 Gene

Publications for NLRX1 Gene

  1. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N … Nuñez G (Nature reviews. Immunology 2003) 2 3 4 58
  2. Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator. (PMID: 22386589) Hong M … Wilson IA (Immunity 2012) 3 4 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. NLRX1 is a regulator of mitochondrial antiviral immunity. (PMID: 18200010) Moore CB … Ting JP (Nature 2008) 3 4 58

Products for NLRX1 Gene

Sources for NLRX1 Gene

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