Aliases for NLRP7 Gene
- NLR Family Pyrin Domain Containing 7 2 3 5
- PYPAF3 2 3 4
- NOD12 2 3 4
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 7 2 3
- Nucleotide-Binding Oligomerization Domain Protein 12 3 4
- NACHT, Leucine Rich Repeat And PYD Containing 7 2 3
- NACHT, LRR And PYD Domains-Containing Protein 7 3 4
External Ids for NLRP7 Gene
Previous HGNC Symbols for NLRP7 Gene
Previous GeneCards Identifiers for NLRP7 Gene
This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for NLRP7 Gene
NLRP7 (NLR Family Pyrin Domain Containing 7) is a Protein Coding gene. Diseases associated with NLRP7 include Hydatidiform Mole, Recurrent, 1 and Partial Hydatidiform Mole. Among its related pathways are Toll-Like receptor Signaling Pathways and Nucleotide-binding Oligomerization Domain (NOD) pathway. An important paralog of this gene is NLRP2.
UniProtKB/Swiss-Prot Summary for NLRP7 Gene
Inhibits CASP1/caspase-1-dependent IL1B secretion.