Aliases for NLRP4 Gene
External Ids for NLRP4 Gene
Previous HGNC Symbols for NLRP4 Gene
Previous GeneCards Identifiers for NLRP4 Gene
The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]
GeneCards Summary for NLRP4 Gene
NLRP4 (NLR Family Pyrin Domain Containing 4) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Innate Immune System. An important paralog of this gene is NLRP12.
UniProtKB/Swiss-Prot Summary for NLRP4 Gene
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.