The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced m... See more...

Aliases for NLRP14 Gene

Aliases for NLRP14 Gene

  • NLR Family Pyrin Domain Containing 14 2 3 5
  • NOD5 2 3 4
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 14 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 5 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 14 2 3
  • NACHT, LRR And PYD Domains-Containing Protein 14 3 4
  • CLR11.2 2 3
  • GC-LRR 2 3
  • NALP14 3 4
  • PAN8 2 3
  • NACHT, LRR And PYD Containing Protein 14 3
  • Nalp-Iota 2
  • NLRP14 5

External Ids for NLRP14 Gene

Previous HGNC Symbols for NLRP14 Gene

  • NALP14

Previous GeneCards Identifiers for NLRP14 Gene

  • GC11P007017
  • GC11P006700

Summaries for NLRP14 Gene

Entrez Gene Summary for NLRP14 Gene

  • The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP14 Gene

NLRP14 (NLR Family Pyrin Domain Containing 14) is a Protein Coding gene. Diseases associated with NLRP14 include Steroid-Induced Glaucoma. An important paralog of this gene is NLRP3.

UniProtKB/Swiss-Prot Summary for NLRP14 Gene

Gene Wiki entry for NLRP14 Gene

Additional gene information for NLRP14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NLRP14 Gene

Genomics for NLRP14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NLRP14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007019 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 -0.1 -137 2.5 TEAD4 RFX1 KDM1A PKNOX1 POLR2A ZNF24 REST SP1 ZNF501 GABPA ZNF214 NLRP14 lnc-OR2D2-2 piR-48528 DNHD1 ENSG00000254641 C11orf42 CYB5R2 ARFIP2 ZNF215
GH11J006991 Enhancer 0.8 Ensembl ENCODE 11.3 -28.0 -28041 2.5 FOXA1 ZIC2 ZNF792 ZBTB20 ZXDB CEBPB ZNF335 BHLHE40 MAFK ZFP3 NLRP14 ZNF214 GVINP1 ZNF215 lnc-ZNF214-1 piR-61580-072
GH11J007071 Enhancer 0.5 ENCODE 16.1 +52.7 52743 3.3 NR2F1 TAL1 NR2F6 ZEB2 CBFA2T3 NLRP14 ZNF214 OVCH2 OLFML1 piR-38352-065 RBMXL2
GH11J007890 Enhancer 1.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas 5 +872.4 872351 6.4 CTCF POLR2A REST RAD21 EZH2 IKZF2 SP1 TRIM22 GABPA PKNOX1 piR-48543 OR10A3 NLRP14 OR10A6 piR-31362 ENSG00000254951 LOC283299 OR5P3
GH11J007057 Enhancer 0.3 Ensembl 0.3 +37.0 36955 1.6 MEIS2 RBMXL2 piR-38580-049 piR-38352-065 NLRP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NLRP14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NLRP14

Top Transcription factor binding sites by QIAGEN in the NLRP14 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for NLRP14 Gene

Genomic Locations for NLRP14 Gene
chr11:7,020,446-7,089,025
(GRCh38/hg38)
Size:
68,580 bases
Orientation:
Plus strand
chr11:7,041,677-7,092,757
(GRCh37/hg19)
Size:
51,081 bases
Orientation:
Plus strand

Genomic View for NLRP14 Gene

Genes around NLRP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP14 Gene

Proteins for NLRP14 Gene

  • Protein details for NLRP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86W24-NAL14_HUMAN
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 14
    Protein Accession:
    Q86W24
    Secondary Accessions:
    • Q7RTR6

    Protein attributes for NLRP14 Gene

    Size:
    1093 amino acids
    Molecular mass:
    124733 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NLRP14 Gene

neXtProt entry for NLRP14 Gene

Post-translational modifications for NLRP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NLRP14
  • Boster Bio Antibodies for NLRP14
  • Santa Cruz Biotechnology (SCBT) Antibodies for NLRP14

No data available for DME Specific Peptides for NLRP14 Gene

Domains & Families for NLRP14 Gene

Gene Families for NLRP14 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NLRP14 Gene

Suggested Antigen Peptide Sequences for NLRP14 Gene

GenScript: Design optimal peptide antigens:
  • Nucleotide-binding oligomerization domain protein 5 (NAL14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q86W24

UniProtKB/Swiss-Prot:

NAL14_HUMAN :
  • Upon heterologous expression, a small proportion of the isolated Pyrin domain forms homodimers and higher oligomers.
  • Belongs to the NLRP family.
Domain:
  • Upon heterologous expression, a small proportion of the isolated Pyrin domain forms homodimers and higher oligomers.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP14: view

Function for NLRP14 Gene

Molecular function for NLRP14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in inflammation and spermatogenesis.

Gene Ontology (GO) - Molecular Function for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP14: view
genes like me logo Genes that share phenotypes with NLRP14: view

Animal Model Products

CRISPR Products

miRNA for NLRP14 Gene

miRTarBase miRNAs that target NLRP14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NLRP14

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP14 Gene

Localization for NLRP14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRP14 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP14 gene
Compartment Confidence
cytosol 4
plasma membrane 2
extracellular 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with NLRP14: view

Pathways & Interactions for NLRP14 Gene

PathCards logo

SuperPathways for NLRP14 Gene

No Data Available

Interacting Proteins for NLRP14 Gene

Gene Ontology (GO) - Biological Process for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IMP 16931801
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with NLRP14: view

No data available for Pathways by source and SIGNOR curated interactions for NLRP14 Gene

Drugs & Compounds for NLRP14 Gene

No Compound Related Data Available

Transcripts for NLRP14 Gene

mRNA/cDNA for NLRP14 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NLRP14

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP14 Gene

No ASD Table

Relevant External Links for NLRP14 Gene

GeneLoc Exon Structure for
NLRP14

Expression for NLRP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NLRP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP14 Gene

This gene is overexpressed in Testis (x9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP14 Gene



Protein tissue co-expression partners for NLRP14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NLRP14

SOURCE GeneReport for Unigene cluster for NLRP14 Gene:

Hs.449637

mRNA Expression by UniProt/SwissProt for NLRP14 Gene:

Q86W24-NAL14_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with NLRP14: view

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP14 Gene

Orthologs for NLRP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP14 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NLRP14 30 31
  • 99.09 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NLRP14 30 31
  • 83.76 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NLRP14 30 31
  • 83.21 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Nlrp14 30 17 31
  • 70.54 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nlrp14 30
  • 68 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
OneToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 30 (a)
OneToMany
Species where no ortholog for NLRP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NLRP14 Gene

ENSEMBL:
Gene Tree for NLRP14 (if available)
TreeFam:
Gene Tree for NLRP14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NLRP14: view image

Paralogs for NLRP14 Gene

(12) SIMAP similar genes for NLRP14 Gene using alignment to 1 proteins:

  • NAL14_HUMAN
genes like me logo Genes that share paralogs with NLRP14: view

Variants for NLRP14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NLRP14 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
720447 Benign: not provided 7,062,429(+) C/T SYNONYMOUS_VARIANT
776580 Benign: not provided 7,043,040(+) T/C SYNONYMOUS_VARIANT
789789 Benign: not provided 7,043,320(+) G/T MISSENSE_VARIANT
rs199475880 Not Provided: not provided 7,038,903(+) G/A INTRON_VARIANT
rs199475881 Not Provided: not provided 7,042,635(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for NLRP14 Gene

Structural Variations from Database of Genomic Variants (DGV) for NLRP14 Gene

Variant ID Type Subtype PubMed ID
esv2617222 CNV deletion 19546169
nsv832061 CNV loss 17160897

Variation tolerance for NLRP14 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLRP14 Gene

Human Gene Mutation Database (HGMD)
NLRP14
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRP14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP14 Gene

Disorders for NLRP14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NLRP14 Gene - From: DISEASES

Disorder Aliases PubMed IDs
steroid-induced glaucoma
  • corticosteroid-induced glaucoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NLRP14

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NLRP14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NLRP14 Gene

Publications for NLRP14 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J … Burns K (Nature reviews. Molecular cell biology 2003) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings JR … Jewell DP (Tissue antigens 2010) 3 41
  4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A … Campo E (Cancer research 2008) 3 41
  5. Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. (PMID: 16931801) Westerveld GH … Lombardi MP (Human reproduction (Oxford, England) 2006) 3 4

Products for NLRP14 Gene

Sources for NLRP14 Gene