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Aliases for NLRP14 Gene

Aliases for NLRP14 Gene

  • NLR Family Pyrin Domain Containing 14 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 14 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 5 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 14 2 3
  • NALP14 3 4
  • NOD5 3 4
  • NACHT, LRR And PYD Domains-Containing Protein 14 3
  • NACHT, LRR And PYD Containing Protein 14 3
  • CLR11.2 3
  • GC-LRR 3
  • PAN8 3

External Ids for NLRP14 Gene

Previous HGNC Symbols for NLRP14 Gene

  • NALP14

Previous GeneCards Identifiers for NLRP14 Gene

  • GC11P006700

Summaries for NLRP14 Gene

Entrez Gene Summary for NLRP14 Gene

  • The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

GeneCards Summary for NLRP14 Gene

NLRP14 (NLR Family Pyrin Domain Containing 14) is a Protein Coding gene. An important paralog of this gene is NLRP5.

UniProtKB/Swiss-Prot for NLRP14 Gene

  • May be involved in inflammation and spermatogenesis.

Gene Wiki entry for NLRP14 Gene

Additional gene information for NLRP14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP14 Gene

Genomics for NLRP14 Gene

GeneHancer (GH) Regulatory Elements for NLRP14 Gene

Promoters and enhancers for NLRP14 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J007019 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 650.7 -0.1 -137 2.5 PKNOX1 ZFP64 ARID4B SIN3A YY1 ETS1 ZNF143 SP3 RXRA SP5 ZNF214 NLRP14 PIR41527 DNHD1 ENSG00000254641 C11orf42 CYB5R2 ARFIP2 GC11P006959 GC11M006985
GH11J006991 Enhancer 0.8 Ensembl ENCODE 11.3 -28.0 -28041 2.5 PKNOX1 ZNF792 ZIC2 ZNF843 ZNF335 PRDM6 ZFP3 ZXDB TRIM28 ZBTB20 LOC102724711 ZNF214 NLRP14 GVINP1 ZNF215 GC11M006969 GC11P006959 GC11M006985
GH11J007071 Enhancer 0.4 ENCODE 16.1 +52.7 52743 3.3 CBFA2T3 ZEB2 NLRP14 ZNF214 OVCH2 OLFML1 GC11M006985 GC11P007052 GC11P007045
GH11J007890 Enhancer 1.2 FANTOM5 Ensembl ENCODE 5 +872.7 872650 5.8 ELF3 CTCF PKNOX1 EBF1 BATF IRF4 RAD21 RFX5 YY1 POLR2A PIR41542 OR10A3 NLRP14 OR10A6 PIR32361 LOC283299 ENSG00000254951
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NLRP14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NLRP14 gene promoter:
  • NRSF form 1
  • NRSF form 2

Genomic Locations for NLRP14 Gene

Genomic Locations for NLRP14 Gene
68,580 bases
Plus strand
51,081 bases
Plus strand

Genomic View for NLRP14 Gene

Genes around NLRP14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP14 Gene

Proteins for NLRP14 Gene

  • Protein details for NLRP14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 14
    Protein Accession:
    Secondary Accessions:
    • Q7RTR6

    Protein attributes for NLRP14 Gene

    1093 amino acids
    Molecular mass:
    124733 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NLRP14 Gene

neXtProt entry for NLRP14 Gene

Post-translational modifications for NLRP14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP14 Gene

Domains & Families for NLRP14 Gene

Gene Families for NLRP14 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NLRP14 Gene

Suggested Antigen Peptide Sequences for NLRP14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NLRP family.
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP14: view

Function for NLRP14 Gene

Molecular function for NLRP14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in inflammation and spermatogenesis.

Gene Ontology (GO) - Molecular Function for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP14: view
genes like me logo Genes that share phenotypes with NLRP14: view

Animal Model Products

CRISPR Products

miRNA for NLRP14 Gene

miRTarBase miRNAs that target NLRP14

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NLRP14

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP14 Gene

Localization for NLRP14 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP14 gene
Compartment Confidence
cytosol 4
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 COLOCALIZES_WITH cytoplasm IBA --
genes like me logo Genes that share ontologies with NLRP14: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NLRP14 Gene

Pathways & Interactions for NLRP14 Gene

SuperPathways for NLRP14 Gene

No Data Available

Interacting Proteins for NLRP14 Gene

Gene Ontology (GO) - Biological Process for NLRP14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0006954 inflammatory response IBA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IMP 16931801
GO:0010468 regulation of gene expression IBA --
genes like me logo Genes that share ontologies with NLRP14: view

No data available for Pathways by source and SIGNOR curated interactions for NLRP14 Gene

Drugs & Compounds for NLRP14 Gene

No Compound Related Data Available

Transcripts for NLRP14 Gene

mRNA/cDNA for NLRP14 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP14 Gene

NLR family, pyrin domain containing 14:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NLRP14

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP14 Gene

No ASD Table

Relevant External Links for NLRP14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRP14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP14 Gene

This gene is overexpressed in Testis (x9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP14 Gene

Protein tissue co-expression partners for NLRP14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NLRP14 Gene:


SOURCE GeneReport for Unigene cluster for NLRP14 Gene:


mRNA Expression by UniProt/SwissProt for NLRP14 Gene:

Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with NLRP14: view

No data available for Protein differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP14 Gene

Orthologs for NLRP14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLRP14 34 33
  • 99.09 (n)
(Canis familiaris)
Mammalia NLRP14 34 33
  • 83.76 (n)
(Bos Taurus)
Mammalia NLRP14 34 33
  • 83.21 (n)
(Mus musculus)
Mammalia Nlrp14 16 34 33
  • 70.54 (n)
(Rattus norvegicus)
Mammalia Nlrp14 33
  • 68 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
Species where no ortholog for NLRP14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP14 Gene

Gene Tree for NLRP14 (if available)
Gene Tree for NLRP14 (if available)
Evolutionary constrained regions (ECRs) for NLRP14: view image

Paralogs for NLRP14 Gene

(12) SIMAP similar genes for NLRP14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP14: view

Variants for NLRP14 Gene

Sequence variations from dbSNP and Humsavar for NLRP14 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs76274604 benign, not provided, not specified 7,039,746(+) A/T coding_sequence_variant, stop_gained
VAR_036387 A breast cancer sample p.Ser779Cys
rs199475880 not-provided, not provided 7,038,903(+) G/A intron_variant
rs199475881 not-provided, not provided 7,042,635(+) C/A/T coding_sequence_variant, synonymous_variant
rs199475882 not-provided, not provided 7,046,685(+) C/G/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP14 Gene

Variant ID Type Subtype PubMed ID
esv2617222 CNV deletion 19546169
nsv832061 CNV loss 17160897

Variation tolerance for NLRP14 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.94; 89.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLRP14 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP14 Gene

Disorders for NLRP14 Gene

Additional Disease Information for NLRP14

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NLRP14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP14 Gene

Publications for NLRP14 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J … Burns K (Nature reviews. Molecular cell biology 2003) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings JR … Jewell DP (Tissue antigens 2010) 3 44 58
  4. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A … Campo E (Cancer research 2008) 3 44 58
  5. Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure. (PMID: 16931801) Westerveld GH … Lombardi MP (Human reproduction (Oxford, England) 2006) 3 4 58

Products for NLRP14 Gene

Sources for NLRP14 Gene

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