Free for academic non-profit institutions. Other users need a Commercial license

Aliases for NLRP13 Gene

Aliases for NLRP13 Gene

  • NLR Family Pyrin Domain Containing 13 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 13 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 14 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 13 2 3
  • NALP13 3 4
  • NOD14 3 4
  • NACHT, LRR And PYD Domains-Containing Protein 13 3
  • NACHT, LRR And PYD Containing Protein 13 3
  • CLR19.7 3
  • PAN13 3

External Ids for NLRP13 Gene

Previous HGNC Symbols for NLRP13 Gene

  • NALP13

Previous GeneCards Identifiers for NLRP13 Gene

  • GC19M061100
  • GC19M056407
  • GC19M052718

Summaries for NLRP13 Gene

Entrez Gene Summary for NLRP13 Gene

  • This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

GeneCards Summary for NLRP13 Gene

NLRP13 (NLR Family Pyrin Domain Containing 13) is a Protein Coding gene. An important paralog of this gene is NLRP14.

UniProtKB/Swiss-Prot for NLRP13 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP13 Gene

Additional gene information for NLRP13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP13 Gene

Genomics for NLRP13 Gene

GeneHancer (GH) Regulatory Elements for NLRP13 Gene

Promoters and enhancers for NLRP13 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J056293 Enhancer 0.8 FANTOM5 ENCODE 1.9 -363.0 -362963 2.7 NFIC ZNF316 NFIB ZFP36 ZBTB40 MAFK NLRP5 ZSCAN5A NLRP11 NLRP8 ZNF583 NLRP13 LOC105372470 ENSG00000267298 GC19P056275 EDDM13
GH19J055837 Promoter/Enhancer 0.9 EPDnew dbSUPER 0.2 +95.5 95516 0.1 L3MBTL2 MGA NLRP11 NLRP4 NLRP13
GH19J055849 Promoter 0.5 EPDnew 0.2 +83.0 82986 0.1 NLRP4 NLRP11 NLRP13 GC19M055840
GH19J055857 Enhancer 0.3 ENCODE 0.2 +75.0 74986 0.2 SRF NLRP11 NLRP4 NLRP13 GC19M055840
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NLRP13 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NLRP13 Gene

Genomic Locations for NLRP13 Gene
40,645 bases
Minus strand
40,638 bases
Minus strand

Genomic View for NLRP13 Gene

Genes around NLRP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP13 Gene

Proteins for NLRP13 Gene

  • Protein details for NLRP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 13
    Protein Accession:
    Secondary Accessions:
    • Q7RTR5

    Protein attributes for NLRP13 Gene

    1043 amino acids
    Molecular mass:
    118884 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NLRP13 Gene

Post-translational modifications for NLRP13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLRP13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NLRP13 Gene

Domains & Families for NLRP13 Gene

Gene Families for NLRP13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NLRP13 Gene

Suggested Antigen Peptide Sequences for NLRP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NLRP family.
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP13: view

Function for NLRP13 Gene

Molecular function for NLRP13 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Phenotypes From GWAS Catalog for NLRP13 Gene

Gene Ontology (GO) - Molecular Function for NLRP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with NLRP13: view
genes like me logo Genes that share phenotypes with NLRP13: view

Animal Model Products

miRNA for NLRP13 Gene

miRTarBase miRNAs that target NLRP13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP13 Gene

Localization for NLRP13 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP13 gene
Compartment Confidence
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for NLRP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 COLOCALIZES_WITH cytoplasm IBA --
genes like me logo Genes that share ontologies with NLRP13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for NLRP13 Gene

Pathways & Interactions for NLRP13 Gene

SuperPathways for NLRP13 Gene

No Data Available

Interacting Proteins for NLRP13 Gene

Gene Ontology (GO) - Biological Process for NLRP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IBA --
GO:0006954 inflammatory response IBA --
GO:0010468 regulation of gene expression IBA --
GO:0023052 signaling IBA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IBA --
genes like me logo Genes that share ontologies with NLRP13: view

No data available for Pathways by source and SIGNOR curated interactions for NLRP13 Gene

Drugs & Compounds for NLRP13 Gene

No Compound Related Data Available

Transcripts for NLRP13 Gene

mRNA/cDNA for NLRP13 Gene

(2) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for NLRP13 Gene

NLR family, pyrin domain containing 13:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP13 Gene

No ASD Table

Relevant External Links for NLRP13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP13 Gene

This gene is overexpressed in Breast - Mammary Tissue (x29.0), Ovary (x9.6), Testis (x5.6), and Prostate (x5.3).

Protein differential expression in normal tissues from HIPED for NLRP13 Gene

This gene is overexpressed in Colon (37.9) and Gallbladder (18.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLRP13 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRP13 Gene:


SOURCE GeneReport for Unigene cluster for NLRP13 Gene:

genes like me logo Genes that share expression patterns with NLRP13: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP13 Gene

Orthologs for NLRP13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLRP13 34 33
  • 99.49 (n)
(Canis familiaris)
Mammalia NLRP13 34 33
  • 74.8 (n)
(Bos Taurus)
Mammalia NLRP13 34 33
  • 60.82 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 30 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
Species where no ortholog for NLRP13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP13 Gene

Gene Tree for NLRP13 (if available)
Gene Tree for NLRP13 (if available)
Evolutionary constrained regions (ECRs) for NLRP13: view image

Paralogs for NLRP13 Gene

(11) SIMAP similar genes for NLRP13 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NLRP13: view

Variants for NLRP13 Gene

Sequence variations from dbSNP and Humsavar for NLRP13 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs796052177 likely-benign, Long QT syndrome 55,932,122(-) C/T coding_sequence_variant, missense_variant
rs199475874 not-provided, not provided 55,923,967(-) G/A coding_sequence_variant, missense_variant
rs199475875 not-provided, not provided 55,912,287(-) C/A/T coding_sequence_variant, synonymous_variant
rs199475876 not-provided, not provided 55,911,780(-) C/A/T coding_sequence_variant, missense_variant, synonymous_variant
rs199475877 not-provided, not provided 55,902,174(-) A/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP13 Gene

Variant ID Type Subtype PubMed ID
dgv3680n100 CNV gain 25217958
dgv3681n100 CNV gain 25217958
dgv6582n54 CNV gain 21841781
esv3575086 CNV gain 25503493
esv3644849 CNV gain 21293372
esv3644851 CNV gain 21293372
esv3644852 CNV gain 21293372
nsv1057383 CNV gain 25217958
nsv1064105 CNV gain 25217958
nsv1067116 CNV gain 25217958
nsv1110333 CNV duplication 24896259
nsv1138730 CNV deletion 24896259
nsv510927 OTHER complex 20534489
nsv580351 CNV gain 21841781

Variation tolerance for NLRP13 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLRP13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP13 Gene

Disorders for NLRP13 Gene

Additional Disease Information for NLRP13

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NLRP13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP13 Gene

Publications for NLRP13 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J … Burns K (Nature reviews. Molecular cell biology 2003) 2 3 4 58
  2. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings JR … Jewell DP (Tissue antigens 2010) 3 44 58
  3. Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. (PMID: 19074885) Enjuanes A … Campo E (Cancer research 2008) 3 44 58
  4. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N … Nuñez G (Nature reviews. Immunology 2003) 3 4 58
  5. What do we know about the inflammasome in humans? (PMID: 27997042) Amin J … Rakic S (Brain pathology (Zurich, Switzerland) 2017) 3 58

Products for NLRP13 Gene

Sources for NLRP13 Gene

Loading form....