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Aliases for NLRP11 Gene

Aliases for NLRP11 Gene

  • NLR Family Pyrin Domain Containing 11 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 11 2 3
  • Nucleotide-Binding Oligomerization Domain Protein 17 3 4
  • NACHT, Leucine Rich Repeat And PYD Containing 11 2 3
  • PAAD-And NACHT Domain-Containing Protein 10 3 4
  • PYRIN-Containing APAF1-Like Protein 6 3 4
  • NALP11 3 4
  • PYPAF6 3 4
  • NOD17 3 4
  • PAN10 3 4
  • NACHT, LRR And PYD Domains-Containing Protein 11 3
  • PAAD- And NACHT-Containing Protein 10B 3
  • CLR19.6 3
  • PYPAF7 3

External Ids for NLRP11 Gene

Previous HGNC Symbols for NLRP11 Gene

  • NALP11

Previous GeneCards Identifiers for NLRP11 Gene

  • GC19M060989
  • GC19M056298
  • GC19M052608

Summaries for NLRP11 Gene

Entrez Gene Summary for NLRP11 Gene

  • This gene is a member of the the NOD-like receptor protein (NLRP) gene family and encodes a protein with an N-terminal pyrin death (PYD) domain and nucleoside triphosphate hydrolase (NACHT) domain and a C-terminal leucine-rich repeats (LRR) region. This gene has been shown to regulate caspases in the proinflammatory signal transduction pathway and, based on studies of other members of the NLRP gene family with similar domain structure, is predicted to form part of the multiprotein inflammasome complex. Alternative splicing produces multiple transcript variants encoding distince isoforms. [provided by RefSeq, May 2017]

GeneCards Summary for NLRP11 Gene

NLRP11 (NLR Family Pyrin Domain Containing 11) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. An important paralog of this gene is NLRP4.

UniProtKB/Swiss-Prot for NLRP11 Gene

  • Involved in inflammation.

Gene Wiki entry for NLRP11 Gene

Additional gene information for NLRP11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRP11 Gene

Genomics for NLRP11 Gene

GeneHancer (GH) Regulatory Elements for NLRP11 Gene

Promoters and enhancers for NLRP11 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I055836 Promoter 0.8 EPDnew 550.8 +0.3 279 0.1 PKNOX1 ZNF316 L3MBTL2 NFE2 MAFK EMSY MGA NLRP11 NLRP4
GH19I055831 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +4.8 4795 0.1 NLRP11 NLRP4 RFPL4AP1
GH19I055837 Enhancer 0.4 dbSUPER 550.8 -1.9 -1866 3.8 L3MBTL2 MGA NLRP11 ENSG00000267523 NLRP4 NLRP13 GC19M055840
GH19I055466 Enhancer 0.6 FANTOM5 5.8 +370.4 370418 0.3 SMARCE1 BCOR HDGF ZMYM3 ZNF311 ZNF48 ZNF121 FOSL1 GATA3 DIDO1 ENSG00000279063 C19orf85 SBK3 NLRP11 NLRP8 NLRP9
GH19I056089 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 2.2 -254.8 -254791 3.4 PKNOX1 NFIB KLF17 SIN3A FEZF1 IRF4 BRCA1 RFX5 RCOR1 FOS NLRP5 NLRP11 ZSCAN5A NLRP8 ENSG00000223060 LINC01864 ZNF787 GC19P056014
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NLRP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NLRP11 gene promoter:

Genomic Locations for NLRP11 Gene

Genomic Locations for NLRP11 Gene
51,404 bases
Minus strand

Genomic View for NLRP11 Gene

Genes around NLRP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRP11 Gene

Proteins for NLRP11 Gene

  • Protein details for NLRP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NACHT, LRR and PYD domains-containing protein 11
    Protein Accession:
    Secondary Accessions:
    • C9JSF5
    • Q2TV85
    • Q2TV86
    • Q53ZZ0
    • Q8NBF5

    Protein attributes for NLRP11 Gene

    1033 amino acids
    Molecular mass:
    117779 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC03490.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRP11 Gene


neXtProt entry for NLRP11 Gene

Post-translational modifications for NLRP11 Gene

  • Ubiquitination at isoforms=2, 3917
  • Modification sites at PhosphoSitePlus

Other Protein References for NLRP11 Gene

No data available for DME Specific Peptides for NLRP11 Gene

Domains & Families for NLRP11 Gene

Gene Families for NLRP11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NLRP11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NLRP family.
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRP11: view

Function for NLRP11 Gene

Molecular function for NLRP11 Gene

UniProtKB/Swiss-Prot Function:
Involved in inflammation.

Phenotypes From GWAS Catalog for NLRP11 Gene

Gene Ontology (GO) - Molecular Function for NLRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA,HDA 22658674
GO:0005524 ATP binding IEA --
GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA --
genes like me logo Genes that share ontologies with NLRP11: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLRP11 Gene

Localization for NLRP11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLRP11 gene
Compartment Confidence
plasma membrane 3
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NLRP11 Gene

Pathways & Interactions for NLRP11 Gene

SuperPathways for NLRP11 Gene

No Data Available

Interacting Proteins for NLRP11 Gene

Selected Interacting proteins: P59045-NAL11_HUMAN for NLRP11 Gene via IID

Gene Ontology (GO) - Biological Process for NLRP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with NLRP11: view

No data available for Pathways by source and SIGNOR curated interactions for NLRP11 Gene

Drugs & Compounds for NLRP11 Gene

No Compound Related Data Available

Transcripts for NLRP11 Gene

Unigene Clusters for NLRP11 Gene

NLR family, pyrin domain containing 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRP11 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -

Relevant External Links for NLRP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLRP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NLRP11 Gene

This gene is overexpressed in Testis (x22.2), Liver (x8.9), and Ovary (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of NLRP11 Gene:


SOURCE GeneReport for Unigene cluster for NLRP11 Gene:

genes like me logo Genes that share expression patterns with NLRP11: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRP11 Gene

Orthologs for NLRP11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLRP11 34 33
  • 99.35 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 26 (a)
Species where no ortholog for NLRP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NLRP11 Gene

Gene Tree for NLRP11 (if available)
Gene Tree for NLRP11 (if available)

Paralogs for NLRP11 Gene

(6) SIMAP similar genes for NLRP11 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with NLRP11: view

Variants for NLRP11 Gene

Sequence variations from dbSNP and Humsavar for NLRP11 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs199475739 not-provided, not provided 55,836,456(-) C/G/T 5_prime_UTR_variant, genic_upstream_transcript_variant
rs199475740 not-provided, not provided 55,836,542(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant
rs199475741 not-provided, not provided 55,836,725(-) T/G 5_prime_UTR_variant, genic_upstream_transcript_variant
rs199475742 not-provided, not provided 55,836,825(-) G/A upstream_transcript_variant
rs199475743 not-provided, not provided 55,836,940(-) G/A/C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NLRP11 Gene

Variant ID Type Subtype PubMed ID
dgv6582n54 CNV gain 21841781
esv2586154 CNV deletion 19546169
esv2660360 CNV deletion 23128226
esv2718989 CNV deletion 23290073
esv2758773 CNV gain 17122850
esv3575075 CNV gain 25503493
esv3644847 CNV loss 21293372
esv3644848 CNV loss 21293372
esv3644849 CNV gain 21293372
esv3893253 CNV loss 25118596
nsv1057383 CNV gain 25217958
nsv1058122 CNV gain 25217958
nsv1060269 CNV gain 25217958
nsv1060544 CNV gain 25217958
nsv1064105 CNV gain 25217958
nsv1066324 CNV gain+loss 25217958
nsv1115552 CNV duplication 24896259
nsv1150950 CNV duplication 26484159
nsv2556 CNV insertion 18451855
nsv509753 CNV insertion 20534489
nsv510927 OTHER complex 20534489
nsv525923 CNV loss 19592680
nsv526248 CNV loss 19592680
nsv580346 CNV gain 21841781
nsv833882 CNV loss 17160897

Variation tolerance for NLRP11 Gene

Residual Variation Intolerance Score: 39.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.80; 66.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLRP11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLRP11 Gene

Disorders for NLRP11 Gene

Additional Disease Information for NLRP11

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NLRP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRP11 Gene

Publications for NLRP11 Gene

  1. NALPs: a novel protein family involved in inflammation. (PMID: 12563287) Tschopp J … Burns K (Nature reviews. Molecular cell biology 2003) 2 3 4 58
  2. PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. (PMID: 12019269) Wang L … Bertin J (The Journal of biological chemistry 2002) 2 3 4 58
  3. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 44 58
  4. The genetics of NOD-like receptors in Crohn's disease. (PMID: 20403135) Cummings JR … Jewell DP (Tissue antigens 2010) 3 44 58
  5. Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. (PMID: 19010793) Baranzini SE … Oksenberg JR (Human molecular genetics 2009) 3 44 58

Products for NLRP11 Gene

Sources for NLRP11 Gene

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