Aliases for NLRP10 Gene
- NLR Family Pyrin Domain Containing 10 2 3 5
- Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 10 2 3
- Nucleotide-Binding Oligomerization Domain Protein 8 3 4
- NACHT, LRR And PYD Domains-Containing Protein 10 3 4
- NACHT, Leucine Rich Repeat And PYD Containing 10 2 3
External Ids for NLRP10 Gene
Previous HGNC Symbols for NLRP10 Gene
Previous GeneCards Identifiers for NLRP10 Gene
Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for NLRP10 Gene
NLRP10 (NLR Family Pyrin Domain Containing 10) is a Protein Coding gene. Diseases associated with NLRP10 include Diabetes Mellitus, Insulin-Dependent, 24 and Irritant Dermatitis. Among its related pathways are Nucleotide-binding Oligomerization Domain (NOD) pathway. An important paralog of this gene is NLRP3.
UniProtKB/Swiss-Prot Summary for NLRP10 Gene
Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819).