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Aliases for NLRC3 Gene

Aliases for NLRC3 Gene

  • NLR Family CARD Domain Containing 3 2 3 5
  • Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And CARD Domain Containing 3 2 3
  • NACHT, LRR And CARD Domains-Containing Protein 3 3 4
  • Caterpiller Protein 16.2 3 4
  • NOD-Like Receptor C3 2 3
  • CARD15-Like Protein 3 4
  • CLR16.2 3 4
  • NOD3 3 4
  • Nucleotide-Binding Oligomerization Domain Protein 3 4
  • NLR Family CARD Domain-Containing Protein 3 3

External Ids for NLRC3 Gene

Previous GeneCards Identifiers for NLRC3 Gene

  • GC16M003531
  • GC16M003591
  • GC16M003592

Summaries for NLRC3 Gene

Entrez Gene Summary for NLRC3 Gene

  • This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for NLRC3 Gene

NLRC3 (NLR Family CARD Domain Containing 3) is a Protein Coding gene. Among its related pathways are Toll-like Receptor Signaling Pathway and Cytosolic sensors of pathogen-associated DNA. An important paralog of this gene is NOD1.

UniProtKB/Swiss-Prot for NLRC3 Gene

  • Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating Lys-63-linked ubiquitination and leaving unchanged the degradative Lys-48-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).

Gene Wiki entry for NLRC3 Gene

Additional gene information for NLRC3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLRC3 Gene

Genomics for NLRC3 Gene

GeneHancer (GH) Regulatory Elements for NLRC3 Gene

Promoters and enhancers for NLRC3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J003575 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 660.9 +0.1 133 6.2 NFIB ZNF335 ZNF121 ZNF143 ETV6 BCLAF1 IKZF2 RUNX3 CREM EGR2 NLRC3 GC16P003578 CLUAP1 CREBBP SRRM2 ENSG00000261938 ZNF597 ZNF263 ZNF174 LOC105371055
GH16J003556 Promoter 0.5 EPDnew 650.3 +21.4 21393 0.1 GC16M003552 NLRC3 SLX4 LOC105371060 LOC101929732
GH16J003499 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 19.4 +77.4 77418 2.5 PKNOX1 CLOCK FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B CLUAP1 NLRC3 ZNF200 ZSCAN32 ZNF174 TRAP1 ZNF205-AS1 ENSG00000278942 ENSG00000263212
GH16J003609 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 -33.1 -33124 3.8 HDGF FOXA2 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 POLR2B ZNF207 ZNF143 DNASE1 SLX4 CLUAP1 ENSG00000261938 CREBBP LOC105371055 NLRC3 ZNF174 ERVK13-1 ZNF75A
GH16J003644 Enhancer 1.3 Ensembl ENCODE dbSUPER 16.8 -68.1 -68108 3.5 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A FOS DEK RXRA SP5 MIER3 NLRC3 CLUAP1 SRRM2 DNASE1 CREBBP ZNF263 THOC6 ENSG00000261938 ZNF597 ERVK13-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NLRC3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NLRC3 gene promoter:
  • AP-1
  • c-Jun
  • c-Fos
  • ATF-2
  • ZID
  • HSF2

Genomic Locations for NLRC3 Gene

Genomic Locations for NLRC3 Gene
chr16:3,539,033-3,578,373
(GRCh38/hg38)
Size:
39,341 bases
Orientation:
Minus strand
chr16:3,589,033-3,627,401
(GRCh37/hg19)
Size:
38,369 bases
Orientation:
Minus strand

Genomic View for NLRC3 Gene

Genes around NLRC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLRC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLRC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLRC3 Gene

Proteins for NLRC3 Gene

  • Protein details for NLRC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7RTR2-NLRC3_HUMAN
    Recommended name:
    NLR family CARD domain-containing protein 3
    Protein Accession:
    Q7RTR2
    Secondary Accessions:
    • Q5EY36
    • Q8NF48
    • Q8NI01
    • Q8NI02
    • Q8TEL3

    Protein attributes for NLRC3 Gene

    Size:
    1065 amino acids
    Molecular mass:
    114658 Da
    Quaternary structure:
    • Directly interacts (via CARD) with TMEM173/STING; this interaction reduces TMEM173 trafficking to the perinuclear region in response to interferon stimulatory DNA. Also interacts, but to a lesser extent, with TBK1 (PubMed:24560620). Interacts with TRAF6; this interaction results in decreased TRAF6 Lys-63-linked polyubiquitination, but leaves Lys-48-linked chains unchanged, promoting TRAF6 protein degradation (PubMed:22863753). Interacts with PIK3R1/PIK3R2; this interaction disrupts the association between PIK3R1/PIK3R2 and the p110 catalytic subunit PIK3CA/PIK3CB/PIK3CD and reduces PIK3R1/PIK3R2 activation (By similarity). Weakly interacts with PYCARD/ASC. Interacts with CASP1 and CASP5 (PubMed:25277106).
    SequenceCaution:
    • Sequence=BAC03412.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for NLRC3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NLRC3 Gene

Post-translational modifications for NLRC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLRC3 Gene

Domains & Families for NLRC3 Gene

Gene Families for NLRC3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NLRC3 Gene

Suggested Antigen Peptide Sequences for NLRC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q7RTR2

UniProtKB/Swiss-Prot:

NLRC3_HUMAN :
  • The leucine-rich repeat domain may reduce the interaction with TMEM173/STING.
  • Belongs to the NLRP family.
Domain:
  • The leucine-rich repeat domain may reduce the interaction with TMEM173/STING.
Family:
  • Belongs to the NLRP family.
genes like me logo Genes that share domains with NLRC3: view

Function for NLRC3 Gene

Molecular function for NLRC3 Gene

UniProtKB/Swiss-Prot Function:
Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating Lys-63-linked ubiquitination and leaving unchanged the degradative Lys-48-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106).
UniProtKB/Swiss-Prot Induction:
In primary T-cells, down-regulated upon T-cell receptor activation (PubMed:15705585). Down-regulated in peritoneal macrophages soon after the beginning of LPS stimulation. Levels start increasing again after 3 days of LPS treatment (PubMed:22863753).

Phenotypes From GWAS Catalog for NLRC3 Gene

Gene Ontology (GO) - Molecular Function for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI,IEA 24560620
GO:0005524 ATP binding IEA --
GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding ISS --
genes like me logo Genes that share ontologies with NLRC3: view
genes like me logo Genes that share phenotypes with NLRC3: view

Animal Models for NLRC3 Gene

MGI Knock Outs for NLRC3:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLRC3 Gene

Localization for NLRC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLRC3 Gene

Cytoplasm.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 15705585
GO:0005815 microtubule organizing center IDA --
GO:0005829 cytosol IDA --
GO:0048471 perinuclear region of cytoplasm IDA 24560620
genes like me logo Genes that share ontologies with NLRC3: view

No data available for Subcellular locations from COMPARTMENTS for NLRC3 Gene

Pathways & Interactions for NLRC3 Gene

genes like me logo Genes that share pathways with NLRC3: view

Interacting Proteins for NLRC3 Gene

Gene Ontology (GO) - Biological Process for NLRC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007249 I-kappaB kinase/NF-kappaB signaling IDA 15705585
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling ISS --
GO:0023052 signaling IBA --
GO:0032088 negative regulation of NF-kappaB transcription factor activity IDA 15705585
GO:0032687 negative regulation of interferon-alpha production ISS --
genes like me logo Genes that share ontologies with NLRC3: view

No data available for SIGNOR curated interactions for NLRC3 Gene

Drugs & Compounds for NLRC3 Gene

No Compound Related Data Available

Transcripts for NLRC3 Gene

Unigene Clusters for NLRC3 Gene

NLR family, CARD domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLRC3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - -

Relevant External Links for NLRC3 Gene

GeneLoc Exon Structure for
NLRC3
ECgene alternative splicing isoforms for
NLRC3

Expression for NLRC3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLRC3 Gene

mRNA differential expression in normal tissues according to GTEx for NLRC3 Gene

This gene is overexpressed in Whole Blood (x6.7) and Spleen (x6.4).

Protein differential expression in normal tissues from HIPED for NLRC3 Gene

This gene is overexpressed in Platelet (49.8) and Spleen (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NLRC3 Gene



Protein tissue co-expression partners for NLRC3 Gene

NURSA nuclear receptor signaling pathways regulating expression of NLRC3 Gene:

NLRC3

SOURCE GeneReport for Unigene cluster for NLRC3 Gene:

Hs.592091
genes like me logo Genes that share expression patterns with NLRC3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLRC3 Gene

Orthologs for NLRC3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NLRC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NLRC3 34 33
  • 97.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NLRC3 34 33
  • 86.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NLRC3 34 33
  • 85.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nlrc3 33
  • 81.43 (n)
mouse
(Mus musculus)
Mammalia Nlrc3 16 34 33
  • 81.34 (n)
oppossum
(Monodelphis domestica)
Mammalia NLRC3 34
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NLRC3 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves NLRC3 34 33
  • 67.36 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NLRC3 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nlrc3 33
  • 57.82 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334206 33
  • 54.89 (n)
nlrc3 34
  • 44 (a)
OneToOne
Species where no ortholog for NLRC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NLRC3 Gene

ENSEMBL:
Gene Tree for NLRC3 (if available)
TreeFam:
Gene Tree for NLRC3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NLRC3: view image

Paralogs for NLRC3 Gene

Paralogs for NLRC3 Gene

(2) SIMAP similar genes for NLRC3 Gene using alignment to 5 proteins:

  • NLRC3_HUMAN
  • B5MDB6_HUMAN
  • C3VPR7_HUMAN
  • C9JLH9_HUMAN
  • H3BLT9_HUMAN
genes like me logo Genes that share paralogs with NLRC3: view

Variants for NLRC3 Gene

Sequence variations from dbSNP and Humsavar for NLRC3 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs190122309 not-provided, not provided 3,544,380(-) T/C intron_variant
rs199475927 not-provided, not provided 3,578,332(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs199475928 not-provided, not provided 3,577,780(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs199475929 not-provided, not provided 3,577,680(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs199475930 not-provided, not provided 3,577,538(-) G/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NLRC3 Gene

Variant ID Type Subtype PubMed ID
nsv833128 CNV loss 17160897
nsv571256 CNV loss 21841781
nsv571255 CNV gain 21841781
nsv517451 CNV loss 19592680
nsv1716 CNV insertion 18451855
esv2750410 CNV deletion 23290073

Additional Variant Information for NLRC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLRC3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for NLRC3 Gene

Disorders for NLRC3 Gene

Additional Disease Information for NLRC3

No disorders were found for NLRC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLRC3 Gene

Publications for NLRC3 Gene

  1. Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein. (PMID: 25277106) Gültekin Y … Özören N (Journal of innate immunity 2015) 2 3 4 58
  2. CATERPILLER 16.2 (CLR16.2), a novel NBD/LRR family member that negatively regulates T cell function. (PMID: 15705585) Conti BJ … Ting JP (The Journal of biological chemistry 2005) 2 3 4 58
  3. NODs: intracellular proteins involved in inflammation and apoptosis. (PMID: 12766759) Inohara N … Nuñez G (Nature reviews. Immunology 2003) 2 3 4 58
  4. NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. (PMID: 24560620) Zhang L … Ting JP (Immunity 2014) 3 4 58
  5. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. (PMID: 22863753) Schneider M … Ting JP (Nature immunology 2012) 3 4 58

Products for NLRC3 Gene

Sources for NLRC3 Gene

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