Aliases for NLN Gene
External Ids for NLN Gene
Previous HGNC Symbols for NLN Gene
Previous GeneCards Identifiers for NLN Gene
This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
GeneCards Summary for NLN Gene
NLN (Neurolysin) is a Protein Coding gene. Diseases associated with NLN include Jackson-Weiss Syndrome. Among its related pathways are Signaling by GPCR and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and peptide binding. An important paralog of this gene is THOP1.
UniProtKB/Swiss-Prot Summary for NLN Gene
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.