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Aliases for NLN Gene

Aliases for NLN Gene

  • Neurolysin 2 3 5
  • Neurotensin Endopeptidase 2 3 4
  • Neurolysin (Metallopeptidase M3 Family) 2 3
  • Mitochondrial Oligopeptidase M 3 4
  • Angiotensin Binding Protein 2 3
  • Microsomal Endopeptidase 3 4
  • AGTBP 3 4
  • MEP 3 4
  • Angiotensin-Binding Protein 4
  • Neurolysin, Mitochondrial 3
  • Endopeptidase 24.16 3
  • EC 4
  • KIAA1226 4
  • EP24.16 3
  • MOP 3

External Ids for NLN Gene

Previous HGNC Symbols for NLN Gene


Previous GeneCards Identifiers for NLN Gene

  • GC05P065169
  • GC05P066556
  • GC05P064988
  • GC05P065033
  • GC05P065053
  • GC05P065018
  • GC05P061976

Summaries for NLN Gene

Entrez Gene Summary for NLN Gene

  • This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]

GeneCards Summary for NLN Gene

NLN (Neurolysin) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and peptide binding. An important paralog of this gene is THOP1.

UniProtKB/Swiss-Prot for NLN Gene

  • Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.

Gene Wiki entry for NLN Gene

Additional gene information for NLN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NLN Gene

Genomics for NLN Gene

GeneHancer (GH) Regulatory Elements for NLN Gene

Promoters and enhancers for NLN Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J065720 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 662.4 -0.1 -50 2.9 PKNOX1 ZNF133 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF48 YY1 ZNF121 NLN SGTB PPWD1 SREK1 CENPK ENSG00000250081 TRIM23
GH05J066142 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.3 +422.5 422454 4.2 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D GLIS1 SREK1 ENSG00000253744 PPWD1 TRAPPC13 TRIM23 NLN SGTB
GH05J065623 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.3 -97.4 -97383 3.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B TRAPPC13 SHLD3 TRIM23 PPWD1 CENPK SREK1 RNU6-540P NLN SGTB
GH05J065809 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.2 +89.8 89842 4.6 MZF1 FEZF1 RAD21 RFX5 ZNF335 TCF12 RCOR1 FOS CEBPB TSHZ1 SGTB NLN ENSG00000252904 TRAPPC13 CENPK GC05P065768 ENSG00000269961
GH05J065742 Enhancer 0.9 Ensembl ENCODE 12 +20.6 20590 1.2 CTCF ATF1 ZBTB21 INSM2 BATF ZNF2 RAD21 RFX5 FOSL1 ZNF366 NLN PPWD1 LOC100419549 GC05P065768
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NLN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NLN gene promoter:
  • STAT1
  • Max
  • E47
  • STAT1alpha
  • STAT1beta
  • Lmo2
  • c-Myc
  • GR-alpha
  • GR

Genomic Locations for NLN Gene

Genomic Locations for NLN Gene
149,530 bases
Plus strand
149,531 bases
Plus strand

Genomic View for NLN Gene

Genes around NLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLN Gene

Proteins for NLN Gene

  • Protein details for NLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neurolysin, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9ULJ4

    Protein attributes for NLN Gene

    704 amino acids
    Molecular mass:
    80652 Da
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NLN Gene

neXtProt entry for NLN Gene

Post-translational modifications for NLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NLN Gene

Domains & Families for NLN Gene

Gene Families for NLN Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NLN Gene

Suggested Antigen Peptide Sequences for NLN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase M3 family.
  • Belongs to the peptidase M3 family.
genes like me logo Genes that share domains with NLN: view

Function for NLN Gene

Molecular function for NLN Gene

UniProtKB/Swiss-Prot Function:
Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage in neurotensin: 10-Pro- -Tyr-11.

Enzyme Numbers (IUBMB) for NLN Gene

Phenotypes From GWAS Catalog for NLN Gene

Gene Ontology (GO) - Molecular Function for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0042277 peptide binding IEA --
genes like me logo Genes that share ontologies with NLN: view
genes like me logo Genes that share phenotypes with NLN: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NLN

miRNA for NLN Gene

miRTarBase miRNAs that target NLN

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NLN Gene

Localization for NLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLN Gene

Mitochondrion intermembrane space. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLN gene
Compartment Confidence
mitochondrion 5
extracellular 4
plasma membrane 3
cytosol 3
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005758 mitochondrial intermembrane space IBA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with NLN: view

Pathways & Interactions for NLN Gene

genes like me logo Genes that share pathways with NLN: view

Pathways by source for NLN Gene

Gene Ontology (GO) - Biological Process for NLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006111 regulation of gluconeogenesis IEA --
GO:0006508 proteolysis IEA --
GO:0006518 peptide metabolic process IBA --
GO:1902809 regulation of skeletal muscle fiber differentiation IEA --
genes like me logo Genes that share ontologies with NLN: view

No data available for SIGNOR curated interactions for NLN Gene

Drugs & Compounds for NLN Gene

(3) Drugs for NLN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
Bradykinin Investigational Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 52

(4) Additional Compounds for NLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NLN: view

Transcripts for NLN Gene

mRNA/cDNA for NLN Gene

Unigene Clusters for NLN Gene

Neurolysin (metallopeptidase M3 family):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NLN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
SP1: - - - - - -
SP2: - - -
SP3: - - - - -

Relevant External Links for NLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NLN Gene

Protein differential expression in normal tissues from HIPED for NLN Gene

This gene is overexpressed in Brain (35.0) and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NLN Gene

Protein tissue co-expression partners for NLN Gene

NURSA nuclear receptor signaling pathways regulating expression of NLN Gene:


SOURCE GeneReport for Unigene cluster for NLN Gene:


Evidence on tissue expression from TISSUES for NLN Gene

  • Nervous system(4.7)
  • Liver(4.4)
genes like me logo Genes that share expression patterns with NLN: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLN Gene

Orthologs for NLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NLN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NLN 34 33
  • 99.34 (n)
(Canis familiaris)
Mammalia NLN 34 33
  • 91.94 (n)
(Bos Taurus)
Mammalia NLN 34 33
  • 90.91 (n)
(Mus musculus)
Mammalia Nln 16 34 33
  • 87.15 (n)
(Rattus norvegicus)
Mammalia Nln 33
  • 86.44 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 80 (a)
-- 34
  • 76 (a)
(Monodelphis domestica)
Mammalia NLN 34
  • 64 (a)
(Gallus gallus)
Aves NLN 34 33
  • 75.54 (n)
(Anolis carolinensis)
Reptilia NLN 34
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nln 33
  • 68.96 (n)
(Danio rerio)
Actinopterygii nln 34
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11771 34 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea ZK550.3 34
  • 16 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C00572g 33
  • 49.35 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRD1 34 33
  • 46.54 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4245 34
  • 58 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06618 33
  • 46.76 (n)
Species where no ortholog for NLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NLN Gene

Gene Tree for NLN (if available)
Gene Tree for NLN (if available)
Evolutionary constrained regions (ECRs) for NLN: view image

Paralogs for NLN Gene

Variants for NLN Gene

Sequence variations from dbSNP and Humsavar for NLN Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000005800 -- 65,825,526(+) TTTT/TTT 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000026857 -- 65,736,606(+) A/G intron_variant
rs1000058191 -- 65,825,914(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000097906 -- 65,740,361(+) T/C intron_variant
rs1000124969 -- 65,809,808(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NLN Gene

Variant ID Type Subtype PubMed ID
esv2676386 CNV deletion 23128226
esv2730277 CNV deletion 23290073
esv29005 CNV gain 19812545
esv3566030 CNV deletion 23714750
esv3605303 CNV loss 21293372
nsv507256 OTHER sequence alteration 20534489
nsv820637 CNV deletion 20802225
nsv980652 CNV duplication 23825009

Variation tolerance for NLN Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.42; 77.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLN Gene

Disorders for NLN Gene

Additional Disease Information for NLN

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NLN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLN Gene

Publications for NLN Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. Swapping the substrate specificities of the neuropeptidases neurolysin and thimet oligopeptidase. (PMID: 17251185) Lim EJ … Rodgers DW (The Journal of biological chemistry 2007) 3 22 58
  5. Endopeptidases and 24.16 in endothelial cells: potential role in vasoactive peptide metabolism. (PMID: 12609826) Norman MU … Lew RA (American journal of physiology. Heart and circulatory physiology 2003) 3 22 58

Products for NLN Gene

Sources for NLN Gene

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