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This gene encodes a member of the metallopeptidase M3 protein family that cleaves neurotensin at the Pro10-Tyr11 bond, leading to the formation of neurotensin(1-10) and neurotensin(11-13). The encoded protein is likely involved in the termination of the neurotensinergic signal in the central nervous system and in the gastrointestinal tract.[provided by RefSeq, Jun 2010]
NLN (Neurolysin) is a Protein Coding gene. Diseases associated with NLN include Jackson-Weiss Syndrome. Among its related pathways are Signaling by GPCR and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include metalloendopeptidase activity and peptide binding. An important paralog of this gene is THOP1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004222 | metalloendopeptidase activity | IEA,TAS | -- |
GO:0008233 | peptidase activity | IEA | -- |
GO:0008237 | metallopeptidase activity | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0042277 | peptide binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005576 | extracellular region | TAS | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005739 | mitochondrion | IEA | -- |
GO:0005758 | mitochondrial intermembrane space | IBA | 21873635 |
GO:0005886 | plasma membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors | ||
2 | Signaling by GPCR | ||
3 | Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006111 | regulation of gluconeogenesis | IEA | -- |
GO:0006508 | proteolysis | IEA,IBA | 21873635 |
GO:0006518 | peptide metabolic process | IBA | 21873635 |
GO:1902809 | regulation of skeletal muscle fiber differentiation | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | NLN 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NLN 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NLN 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Nln 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nln 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | NLN 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NLN 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NLN 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nln 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nln 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG11771 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | ZK550.3 31 |
|
OneToMany | |
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C00572g 30 |
|
||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PRD1 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.4245 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06618 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
769299 | Benign: not provided | 65,792,660(+) | GT/G | INTRON_VARIANT | |
rs2289884 | - | p.Ser417Gly | |||
rs34063558 | - | p.Ser323Gly | |||
rs34339013 | - | p.Gly79Ser | |||
rs6860508 | - | p.Pro704Ser |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2676386 | CNV | deletion | 23128226 |
esv2730277 | CNV | deletion | 23290073 |
esv29005 | CNV | gain | 19812545 |
esv3566030 | CNV | deletion | 23714750 |
esv3605303 | CNV | loss | 21293372 |
nsv507256 | OTHER | sequence alteration | 20534489 |
nsv820637 | CNV | deletion | 20802225 |
nsv980652 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
jackson-weiss syndrome |
|
|