Aliases for NLK Gene

Aliases for NLK Gene

  • Nemo Like Kinase 2 3 5
  • Serine/Threonine-Protein Kinase NLK 3 4
  • Nemo-Like Kinase 2 4
  • EC 2.7.11.24 4 51
  • Protein LAK1 4
  • EC 2.7.11 51
  • LAK1 4
  • NLK 5

External Ids for NLK Gene

Previous GeneCards Identifiers for NLK Gene

  • GC17P026225
  • GC17P028269
  • GC17P026515
  • GC17P026514
  • GC17P023393
  • GC17P026369
  • GC17P022577

Summaries for NLK Gene

GeneCards Summary for NLK Gene

NLK (Nemo Like Kinase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK7.

UniProtKB/Swiss-Prot Summary for NLK Gene

  • Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613).

Gene Wiki entry for NLK Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NLK Gene

Genomics for NLK Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NLK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J028040 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 606.3 +1.1 1064 4.8 SP1 HNRNPL CREB1 PRDM10 ZNF629 RFX1 LEF1 IKZF1 ZNF692 POLR2A NLK LOC105371709 SUPT6H ITM2BP1 PHF12 ENSG00000251818 ENSG00000202389 SARM1 TMEM199 LOC102724517
GH17J027984 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 13.9 -55.5 -55535 3.4 LEF1 IKZF1 JUND DDX20 MTA2 PHF21A PKNOX1 ZNF24 MTA1 REST LYRM9 NLK ENSG00000251818 ENSG00000202389 ENSG00000264577 LINC01992 piR-43105-268
GH17J028081 Enhancer 0.8 Ensembl ENCODE 12.4 +39.4 39364 6.2 PRDM10 SOX13 HMBOX1 CEBPB CREB1 ZBTB17 CREM WT1 CEBPG IRF2 NLK LYRM9 ENSG00000252283 RPS29P22 TMEM97
GH17J028096 Enhancer 0.6 Ensembl 11.5 +55.9 55864 2.4 IKZF2 PKNOX1 ARID3A RELB RUNX3 ZNF316 ZBTB40 MAFG ARNT NBN NLK LYRM9 RPS29P22 ENSG00000252283 TMEM97
GH17J027982 Enhancer 0.6 ENCODE 11.4 -58.6 -58636 0.9 IKZF1 HDAC1 SOX6 CTBP1 GATAD2A USF1 NR2F1 USF2 NR2F6 BHLHE40 NLK ENSG00000202389 ENSG00000251818 LYRM9 PYY2 LGALS9 LINC01992 piR-43105-268
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NLK on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NLK

Top Transcription factor binding sites by QIAGEN in the NLK gene promoter:
  • E2F
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • p300
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for NLK Gene

Genomic Locations for NLK Gene
chr17:28,041,737-28,205,140
(GRCh38/hg38)
Size:
163,404 bases
Orientation:
Plus strand
chr17:26,368,763-26,523,407
(GRCh37/hg19)
Size:
154,645 bases
Orientation:
Plus strand

Genomic View for NLK Gene

Genes around NLK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NLK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NLK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NLK Gene

Proteins for NLK Gene

  • Protein details for NLK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBE8-NLK_HUMAN
    Recommended name:
    Serine/threonine-protein kinase NLK
    Protein Accession:
    Q9UBE8
    Secondary Accessions:
    • B2RCX1
    • Q2PNI9
    • Q6P2A3

    Protein attributes for NLK Gene

    Size:
    527 amino acids
    Molecular mass:
    58283 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Homodimerization is required for intermolecular autophosphorylation, kinase activation and nuclear localization (By similarity). May interact with components of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes (By similarity). Interacts with LEF1, MEF2A, MYBL1 and MYBL2 (By similarity). Interacts with the upstream activating kinases HIPK2 and MAP3K7/TAK1. Interaction with MAP3K7/TAK1 seems to be indirect, and may be mediated by other proteins such as STAT3, TAB1 and TAB2. Interacts with and phosphorylates a number of transcription factors including FOXO1, FOXO3, FOXO4, MYB, NOTCH1 and TCF7L2/TCF4. Interacts with DAPK3/ZIPK, and this interaction may disrupt interaction with transcription factors such as TCF7L2/TCF4. Forms a transcriptional repressor complex with CHD7, PPARG and SETDB1. Interacts with RNF138/NARF. Interacts with ATF5; the interaction stabilizes ATF5 at the protein level in a kinase-independent manner (PubMed:25512613).
    SequenceCaution:
    • Sequence=AAD56013.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAF04857.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABC40748.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG37718.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for NLK Gene

Selected DME Specific Peptides for NLK Gene

Q9UBE8:
  • TDLLGTP
  • GKRVALKKMPNVFQNL
  • WSVGCIFAE
  • KPGNLLVN
  • WSVGCIFAELLGR
  • LRGLKYLHSA
  • YQILRGLKY
  • LKICDFG
  • PDRPIGYGAFGVVWSVTDPR
  • SCKRVFRE
  • DIWSVGCI
  • FDPSKRI
  • HRDIKPGN
  • LKICDFGLAR

Post-translational modifications for NLK Gene

  • Phosphorylated on Thr-298. Intermolecular autophosphorylation on Thr-298 activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NLK Gene

Domains & Families for NLK Gene

Gene Families for NLK Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NLK Gene

Suggested Antigen Peptide Sequences for NLK Gene

GenScript: Design optimal peptide antigens:
  • Protein LAK1 (NLK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UBE8

UniProtKB/Swiss-Prot:

NLK_HUMAN :
  • Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • Contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. This mode of activation contrasts with that of classical MAP kinases, which contain a TXY activation loop motif in which phosphorylation of both the threonine and tyrosine residues is required for kinase activation.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with NLK: view

Function for NLK Gene

Molecular function for NLK Gene

UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that regulates a number of transcription factors with key roles in cell fate determination. Positive effector of the non-canonical Wnt signaling pathway, acting downstream of WNT5A, MAP3K7/TAK1 and HIPK2. Activation of this pathway causes binding to and phosphorylation of the histone methyltransferase SETDB1. The NLK-SETDB1 complex subsequently interacts with PPARG, leading to methylation of PPARG target promoters at histone H3K9 and transcriptional silencing. The resulting loss of PPARG target gene transcription inhibits adipogenesis and promotes osteoblastogenesis in mesenchymal stem cells (MSCs). Negative regulator of the canonical Wnt/beta-catenin signaling pathway. Binds to and phosphorylates TCF7L2/TCF4 and LEF1, promoting the dissociation of the TCF7L2/LEF1/beta-catenin complex from DNA, as well as the ubiquitination and subsequent proteolysis of LEF1. Together these effects inhibit the transcriptional activation of canonical Wnt/beta-catenin target genes. Negative regulator of the Notch signaling pathway. Binds to and phosphorylates NOTCH1, thereby preventing the formation of a transcriptionally active ternary complex of NOTCH1, RBPJ/RBPSUH and MAML1. Negative regulator of the MYB family of transcription factors. Phosphorylation of MYB leads to its subsequent proteolysis while phosphorylation of MYBL1 and MYBL2 inhibits their interaction with the coactivator CREBBP. Other transcription factors may also be inhibited by direct phosphorylation of CREBBP itself. Acts downstream of IL6 and MAP3K7/TAK1 to phosphorylate STAT3, which is in turn required for activation of NLK by MAP3K7/TAK1. Upon IL1B stimulus, cooperates with ATF5 to activate the transactivation activity of C/EBP subfamily members. Phosphorylates ATF5 but also stabilizes ATF5 protein levels in a kinase-independent manner (PubMed:25512613).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.24;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by dimerization and subsequent intermolecular autophosphorylation on Thr-298 (By similarity). Activated by the non-canonical Wnt signaling pathway, in which WNT5A treatment leads to activation of MAP3K7/TAK1 and HIPK2, which subsequently phosphorylates and activates this protein. Other cytokines such as IL6 may also activate this regulatory circuit.

Enzyme Numbers (IUBMB) for NLK Gene

Phenotypes From GWAS Catalog for NLK Gene

Gene Ontology (GO) - Molecular Function for NLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000287 magnesium ion binding ISS --
GO:0004672 protein kinase activity IEA,TAS 10863097
GO:0004674 protein serine/threonine kinase activity IEA,TAS --
GO:0004707 MAP kinase activity IEA,ISS --
genes like me logo Genes that share ontologies with NLK: view
genes like me logo Genes that share phenotypes with NLK: view

Animal Models for NLK Gene

MGI Knock Outs for NLK:
  • Nlk Nlk<tm1Tbo>
  • Nlk Nlk<tm2b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NLK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NLK Gene

Localization for NLK Gene

Subcellular locations from UniProtKB/Swiss-Prot for NLK Gene

Nucleus. Cytoplasm. Note=Predominantly nuclear. A smaller fraction is cytoplasmic (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NLK gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (3)
  • Nucleoli (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NLK: view

Pathways & Interactions for NLK Gene

genes like me logo Genes that share pathways with NLK: view

Pathways by source for NLK Gene

2 R&D Systems pathways for NLK Gene
1 Qiagen pathway for NLK Gene
  • Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for NLK Gene
1 GeneTex pathway for NLK Gene

SIGNOR curated interactions for NLK Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for NLK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006355 regulation of transcription, DNA-templated ISS --
GO:0006468 protein phosphorylation IEA,ISS --
GO:0007179 transforming growth factor beta receptor signaling pathway IMP 15004007
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS --
genes like me logo Genes that share ontologies with NLK: view

Drugs & Compounds for NLK Gene

(3) Drugs for NLK Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with NLK: view

Transcripts for NLK Gene

mRNA/cDNA for NLK Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NLK

Alternative Splicing Database (ASD) splice patterns (SP) for NLK Gene

No ASD Table

Relevant External Links for NLK Gene

GeneLoc Exon Structure for
NLK

Expression for NLK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NLK Gene

mRNA differential expression in normal tissues according to GTEx for NLK Gene

This gene is overexpressed in Brain - Cortex (x5.0) and Brain - Frontal Cortex (BA9) (x5.0).

Protein differential expression in normal tissues from HIPED for NLK Gene

This gene is overexpressed in Brain (49.1) and Retina (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NLK Gene



Protein tissue co-expression partners for NLK Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NLK

SOURCE GeneReport for Unigene cluster for NLK Gene:

Hs.208759

Evidence on tissue expression from TISSUES for NLK Gene

  • Nervous system(4.7)
  • Blood(4.4)
  • Eye(2.6)
  • Kidney(2.1)
  • Intestine(2.1)
  • Bone marrow(2.1)
  • Lung(2)
genes like me logo Genes that share expression patterns with NLK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NLK Gene

Orthologs for NLK Gene

This gene was present in the common ancestor of animals.

Orthologs for NLK Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia NLK 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia NLK 30 31
  • 99.94 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NLK 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia NLK 30 31
  • 97.53 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia NLK 30 31
  • 96.71 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Nlk 30
  • 94.5 (n)
Mouse
(Mus musculus)
Mammalia Nlk 30 17 31
  • 94.43 (n)
OneToOne
Chicken
(Gallus gallus)
Aves NLK 30 31
  • 89.75 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NLK 31
  • 98 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia nlk 30
  • 83.4 (n)
Str.7425 30
African clawed frog
(Xenopus laevis)
Amphibia xnlk 30
Zebrafish
(Danio rerio)
Actinopterygii nlk2 30 31
  • 77.89 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005898 30
  • 66.58 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta nmo 30 31 32
  • 65.9 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea lit-1 30 31
  • 62.31 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3781 31
  • 57 (a)
OneToOne
Species where no ortholog for NLK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for NLK Gene

ENSEMBL:
Gene Tree for NLK (if available)
TreeFam:
Gene Tree for NLK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NLK: view image

Paralogs for NLK Gene

genes like me logo Genes that share paralogs with NLK: view

Variants for NLK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NLK Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
VAR_042273 A glioblastoma multiforme sample p.Ala343Thr
rs11871287 - p.Val177Ala

Additional dbSNP identifiers (rs#s) for NLK Gene

Structural Variations from Database of Genomic Variants (DGV) for NLK Gene

Variant ID Type Subtype PubMed ID
esv2678164 CNV deletion 23128226
esv3353471 CNV insertion 20981092
nsv2016 CNV deletion 18451855
nsv522349 CNV gain 19592680

Variation tolerance for NLK Gene

Residual Variation Intolerance Score: 23.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NLK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NLK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NLK Gene

Disorders for NLK Gene

Additional Disease Information for NLK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for NLK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NLK Gene

Publications for NLK Gene

  1. Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. (PMID: 10863097) Kehrer-Sawatzki H … Krone W (Gene 2000) 2 3 4 23
  2. Regulation of FOXO1 by TAK1-Nemo-like kinase pathway. (PMID: 20061393) Kim S … Chung J (The Journal of biological chemistry 2010) 3 4 23
  3. STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation. (PMID: 15764709) Kojima H … Nakajima K (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
  4. Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. (PMID: 15082531) Kanei-Ishii C … Ishii S (Genes & development 2004) 3 4 23
  5. Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway. (PMID: 25512613) Zhang ZY … Zhang XD (Molecular and cellular biology 2015) 3 4

Products for NLK Gene

Sources for NLK Gene