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NLK (Nemo Like Kinase) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Regulation of activated PAK-2p34 by proteasome mediated degradation. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK7.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0000287 | magnesium ion binding | ISS | -- |
GO:0004672 | protein kinase activity | IEA,TAS | 10863097 |
GO:0004674 | protein serine/threonine kinase activity | IEA,TAS | -- |
GO:0004707 | MAP kinase activity | IEA,ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | TAS,ISS | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MAPK signaling pathway | ||
2 | Wnt signaling pathway | ||
3 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.41
|
|
4 | Mesodermal Commitment Pathway | ||
5 | Wnt / Hedgehog / Notch |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000165 | MAPK cascade | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | ISS | -- |
GO:0006468 | protein phosphorylation | IEA,ISS | -- |
GO:0007179 | transforming growth factor beta receptor signaling pathway | IMP | 15004007 |
GO:0007223 | Wnt signaling pathway, calcium modulating pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Magnesium | Approved, Experimental, Investigational | Pharma | 0 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | NLK 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | NLK 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | NLK 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | NLK 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | NLK 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Nlk 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Nlk 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | NLK 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | NLK 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | nlk 30 |
|
||
Str.7425 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | xnlk 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | nlk2 30 31 |
|
OneToOne | |
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP005898 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | nmo 30 31 32 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | lit-1 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3781 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
VAR_042273 | A glioblastoma multiforme sample | p.Ala343Thr | |||
rs11871287 | - | p.Val177Ala |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2678164 | CNV | deletion | 23128226 |
esv3353471 | CNV | insertion | 20981092 |
nsv2016 | CNV | deletion | 18451855 |
nsv522349 | CNV | gain | 19592680 |
No disorders were found for NLK Gene.