External Ids for NLGN2 Gene
Previous GeneCards Identifiers for NLGN2 Gene
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
GeneCards Summary for NLGN2 Gene
NLGN2 (Neuroligin 2) is a Protein Coding gene. Diseases associated with NLGN2 include Macrocephaly/Autism Syndrome and Childhood Disintegrative Disease. Among its related pathways are Cell adhesion molecules (CAMs) and Protein-protein interactions at synapses. Gene Ontology (GO) annotations related to this gene include hydrolase activity and cell adhesion molecule binding. An important paralog of this gene is NLGN3.
UniProtKB/Swiss-Prot Summary for NLGN2 Gene
Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity).