Aliases for NKX6-2 Gene
External Ids for NKX6-2 Gene
Previous GeneCards Identifiers for NKX6-2 Gene
GeneCards Summary for NKX6-2 Gene
NKX6-2 (NK6 Homeobox 2) is a Protein Coding gene. Diseases associated with NKX6-2 include Spastic Ataxia 8, Autosomal Recessive, With Hypomyelinating Leukodystrophy and Hypomyelinating Leukodystrophy. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is NKX6-1.
UniProtKB/Swiss-Prot Summary for NKX6-2 Gene
Transcription factor with repressor activity involved in the regulation of axon-glial interactions at myelin paranodes in oligodendrocytes. Binds to the consensus DNA sequence 5'-(A/T)TTAATGA-3'. In oligodendrocytes, binds to MBP and PLP1 promoter regions.