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Aliases for NKX3-1 Gene

Aliases for NKX3-1 Gene

  • NK3 Homeobox 1 2 3 5
  • Homeobox Protein NK-3 Homolog A 3 4
  • Homeobox Protein Nkx-3.1 3 4
  • NKX3.1 3 4
  • NKX3A 3 4
  • NK3 Transcription Factor Related, Locus 1 (Drosophila) 2
  • NK3 Transcription Factor Related, Locus 1 3
  • NK Homeobox (Drosophila), Family 3, A 2
  • NK3 Transcription Factor Homolog A 3
  • NK Homeobox, Family 3, A 3
  • BAPX2 3
  • NKX3 3

External Ids for NKX3-1 Gene

Previous HGNC Symbols for NKX3-1 Gene

  • NKX3A

Previous GeneCards Identifiers for NKX3-1 Gene

  • GC08M023268
  • GC08M023889
  • GC08M023558
  • GC08M023592
  • GC08M022081
  • GC08M023536

Summaries for NKX3-1 Gene

Entrez Gene Summary for NKX3-1 Gene

  • This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for NKX3-1 Gene

NKX3-1 (NK3 Homeobox 1) is a Protein Coding gene. Diseases associated with NKX3-1 include Chromosome 8P Deletion and Rete Testis Adenocarcinoma. Among its related pathways are Endometrial cancer and Pathways in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is NKX3-2.

UniProtKB/Swiss-Prot for NKX3-1 Gene

  • Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Gene Wiki entry for NKX3-1 Gene

Additional gene information for NKX3-1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX3-1 Gene

Genomics for NKX3-1 Gene

GeneHancer (GH) Regulatory Elements for NKX3-1 Gene

Promoters and enhancers for NKX3-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKX3-1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKX3-1 gene promoter:
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • HTF
  • p53
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for NKX3-1 Gene

Genomic Locations for NKX3-1 Gene
chr8:23,678,693-23,682,938
(GRCh38/hg38)
Size:
4,246 bases
Orientation:
Minus strand
chr8:23,536,206-23,540,450
(GRCh37/hg19)
Size:
4,245 bases
Orientation:
Minus strand

Genomic View for NKX3-1 Gene

Genes around NKX3-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKX3-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKX3-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX3-1 Gene

Proteins for NKX3-1 Gene

  • Protein details for NKX3-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99801-NKX31_HUMAN
    Recommended name:
    Homeobox protein Nkx-3.1
    Protein Accession:
    Q99801
    Secondary Accessions:
    • O15465
    • Q9H2P4
    • Q9H2P5
    • Q9H2P6
    • Q9H2P7
    • Q9HBG0

    Protein attributes for NKX3-1 Gene

    Size:
    234 amino acids
    Molecular mass:
    26350 Da
    Quaternary structure:
    • Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation.

    Three dimensional structures from OCA and Proteopedia for NKX3-1 Gene

    Alternative splice isoforms for NKX3-1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKX3-1 Gene

Post-translational modifications for NKX3-1 Gene

  • Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX3-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for NKX3-1
  • Boster Bio Antibodies for NKX3-1

No data available for DME Specific Peptides for NKX3-1 Gene

Domains & Families for NKX3-1 Gene

Gene Families for NKX3-1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for NKX3-1 Gene

GenScript: Design optimal peptide antigens:
  • Homeobox protein NK-3 homolog A (NKX31_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99801

UniProtKB/Swiss-Prot:

NKX31_HUMAN :
  • Belongs to the NK-3 homeobox family.
Family:
  • Belongs to the NK-3 homeobox family.
genes like me logo Genes that share domains with NKX3-1: view

Function for NKX3-1 Gene

Molecular function for NKX3-1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.
UniProtKB/Swiss-Prot Induction:
By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen-independent phase.

Phenotypes From GWAS Catalog for NKX3-1 Gene

Gene Ontology (GO) - Molecular Function for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 20855495
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 18974119
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IDA,NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view
genes like me logo Genes that share phenotypes with NKX3-1: view

Animal Models for NKX3-1 Gene

MGI Knock Outs for NKX3-1:

Animal Model Products

CRISPR Products

miRNA for NKX3-1 Gene

Transcription Factor Targets for NKX3-1 Gene

Selected GeneGlobe predicted Target genes for NKX3-1
Targeted motifs for NKX3-1 Gene
HOMER Transcription Factor Regulatory Elements motif NKX3-1
  • Consensus sequence: AAGCACTTAA Submotif: canonical Cell Type: LNCaP GEO ID: GSE28264

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKX3-1

Clone Products

  • Applied Biological Materials (abm): Clones for NKX3-1 - Now 50% OFF >
  • * NKX3-1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NKX3-1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for NKX3-1 Gene

Localization for NKX3-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX3-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKX3-1 gene
Compartment Confidence
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,NAS 11137288
GO:0090734 site of DNA damage IDA 20395202
genes like me logo Genes that share ontologies with NKX3-1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKX3-1 Gene

Pathways & Interactions for NKX3-1 Gene

genes like me logo Genes that share pathways with NKX3-1: view

SIGNOR curated interactions for NKX3-1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NKX3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001656 metanephros development IEA --
GO:0001756 somitogenesis IEA --
GO:0001934 positive regulation of protein phosphorylation IDA 20395202
GO:0006355 regulation of transcription, DNA-templated NAS 11137288
genes like me logo Genes that share ontologies with NKX3-1: view

Drugs & Compounds for NKX3-1 Gene

(2) Drugs for NKX3-1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for NKX3-1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NKX3-1: view

Transcripts for NKX3-1 Gene

mRNA/cDNA for NKX3-1 Gene

(2) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(83) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for NKX3-1 Gene

NK3 homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKX3-1

Clone Products

  • Applied Biological Materials (abm): Clones for NKX3-1 - Now 50% OFF >
  • * NKX3-1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * NKX3-1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for NKX3-1 Gene

No ASD Table

Relevant External Links for NKX3-1 Gene

GeneLoc Exon Structure for
NKX3-1
ECgene alternative splicing isoforms for
NKX3-1

Expression for NKX3-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKX3-1 Gene

mRNA differential expression in normal tissues according to GTEx for NKX3-1 Gene

This gene is overexpressed in Prostate (x29.4) and Minor Salivary Gland (x7.0).

Protein differential expression in normal tissues from HIPED for NKX3-1 Gene

This gene is overexpressed in Heart (43.8) and Prostate (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NKX3-1 Gene



Protein tissue co-expression partners for NKX3-1 Gene

SOURCE GeneReport for Unigene cluster for NKX3-1 Gene:

Hs.55999

mRNA Expression by UniProt/SwissProt for NKX3-1 Gene:

Q99801-NKX31_HUMAN
Tissue specificity: Highly expressed in the prostate and, at a lower level, in the testis.

Evidence on tissue expression from TISSUES for NKX3-1 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with NKX3-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKX3-1 Gene

Orthologs for NKX3-1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX3-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKX3-1 35 34
  • 99.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NKX3-1 35 34
  • 87.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NKX3-1 35 34
  • 80.48 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nkx3-1 17 35 34
  • 73.6 (n)
rat
(Rattus norvegicus)
Mammalia Nkx3-1 34
  • 72.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NKX3-1 35
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NKX3-1 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKX3-1 34
  • 60.93 (n)
SOHO-1 35
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia NKX3-1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkx3-1 34
  • 56.68 (n)
Str.5202 34
African clawed frog
(Xenopus laevis)
Amphibia nkx3-1-prov 34
zebrafish
(Danio rerio)
Actinopterygii nkx3-1 35 34
  • 65.15 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bap 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-27 35
  • 19 (a)
ManyToMany
Species where no ortholog for NKX3-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NKX3-1 Gene

ENSEMBL:
Gene Tree for NKX3-1 (if available)
TreeFam:
Gene Tree for NKX3-1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NKX3-1: view image

Paralogs for NKX3-1 Gene

(1) SIMAP similar genes for NKX3-1 Gene using alignment to 1 proteins:

  • NKX31_HUMAN
genes like me logo Genes that share paralogs with NKX3-1: view

Variants for NKX3-1 Gene

Sequence variations from dbSNP and Humsavar for NKX3-1 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1001460327 -- 23,680,172(-) T/A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1001814841 -- 23,679,795(-) A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs1001941445 -- 23,684,696(-) C/A upstream_transcript_variant
rs1002442915 -- 23,680,164(-) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs1003936267 -- 23,678,683(-) CACACACACA/CACACA downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NKX3-1 Gene

Variant ID Type Subtype PubMed ID
nsv1028341 CNV gain 25217958
nsv831269 CNV gain 17160897

Variation tolerance for NKX3-1 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.85; 48.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKX3-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKX3-1
Human Gene Mutation Database (HGMD)
NKX3-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX3-1 Gene

Disorders for NKX3-1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for NKX3-1 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chromosome 8p deletion
  • 8p deletion
rete testis adenocarcinoma
  • adenocarcinoma of rete testis
rete testis neoplasm
prostatitis
urethral diverticulum
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NKX3-1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NKX3-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKX3-1 Gene

Publications for NKX3-1 Gene

  1. A novel human prostate-specific, androgen-regulated homeobox gene (NKX3.1) that maps to 8p21, a region frequently deleted in prostate cancer. (PMID: 9226374) He WW … Carter KC (Genomics 1997) 2 3 4 23 58
  2. Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1. (PMID: 19462257) Zhang P … Jiang A (Molecular biology reports 2010) 3 4 23 58
  3. Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. (PMID: 12972618) Hosohata K … Wang Z (Molecular and cellular biology 2003) 3 4 23 58
  4. Full-length cDNA sequence and genomic organization of human NKX3A - alternative forms and regulation by both androgens and estrogens. (PMID: 11137288) Korkmaz KS … Saatcioglu F (Gene 2000) 3 4 23 58
  5. Isolation and androgen regulation of the human homeobox cDNA, NKX3.1. (PMID: 9537602) Prescott JL … Tindall DJ (The Prostate 1998) 3 4 23 58

Products for NKX3-1 Gene

Sources for NKX3-1 Gene

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