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Aliases for NKX1-1 Gene

Aliases for NKX1-1 Gene

  • NK1 Homeobox 1 2 3 5
  • Homeobox Protein SAX-2 3 4
  • Homeobox Protein 153 3 4
  • NKX-1.1 3 4
  • NK1 Transcription Factor Related, Locus 1 (Drosophila) 2
  • NK1 Transcription Factor-Related Protein 1 3
  • NK1 Transcription Factor Related, Locus 1 3
  • HPX-153 Homeobox 3
  • HSPX153 3
  • HPX-153 4
  • HPX153 4
  • SAX2 3

External Ids for NKX1-1 Gene

Previous GeneCards Identifiers for NKX1-1 Gene

  • GC04U900463
  • GC04M001380

Summaries for NKX1-1 Gene

Entrez Gene Summary for NKX1-1 Gene

  • This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017]

GeneCards Summary for NKX1-1 Gene

NKX1-1 (NK1 Homeobox 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is NKX1-2.

Additional gene information for NKX1-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKX1-1 Gene

Genomics for NKX1-1 Gene

GeneHancer (GH) Regulatory Elements for NKX1-1 Gene

Promoters and enhancers for NKX1-1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I001406 Promoter 0.7 EPDnew 550.8 +0.0 11 0.1 SUZ12 EZH2 NKX1-1 PIR54652
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NKX1-1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKX1-1 gene promoter:

Genomic Locations for NKX1-1 Gene

Genomic Locations for NKX1-1 Gene
3,511 bases
Minus strand

Genomic View for NKX1-1 Gene

Genes around NKX1-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKX1-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKX1-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKX1-1 Gene

Proteins for NKX1-1 Gene

  • Protein details for NKX1-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NK1 transcription factor-related protein 1
    Protein Accession:

    Protein attributes for NKX1-1 Gene

    411 amino acids
    Molecular mass:
    40659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKX1-1 Gene

Post-translational modifications for NKX1-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKX1-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKX1-1 Gene

Domains & Families for NKX1-1 Gene

Gene Families for NKX1-1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for NKX1-1 Gene

Suggested Antigen Peptide Sequences for NKX1-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NK-1 homeobox family.
  • Belongs to the NK-1 homeobox family.
genes like me logo Genes that share domains with NKX1-1: view

Function for NKX1-1 Gene

Gene Ontology (GO) - Molecular Function for NKX1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NKX1-1: view

Phenotypes for NKX1-1 Gene

genes like me logo Genes that share phenotypes with NKX1-1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NKX1-1 Gene

Localization for NKX1-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKX1-1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKX1-1 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for NKX1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKX1-1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKX1-1 Gene

Pathways & Interactions for NKX1-1 Gene

SuperPathways for NKX1-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKX1-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006629 lipid metabolic process IEA --
GO:0008150 biological_process ND --
GO:0010906 regulation of glucose metabolic process IEA --
GO:0043467 regulation of generation of precursor metabolites and energy IEA --
genes like me logo Genes that share ontologies with NKX1-1: view

No data available for Pathways by source and SIGNOR curated interactions for NKX1-1 Gene

Drugs & Compounds for NKX1-1 Gene

No Compound Related Data Available

Transcripts for NKX1-1 Gene

mRNA/cDNA for NKX1-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for NKX1-1 Gene

No ASD Table

Relevant External Links for NKX1-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKX1-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKX1-1 Gene

mRNA differential expression in normal tissues according to GTEx for NKX1-1 Gene

This gene is overexpressed in Testis (x40.0) and Pituitary (x11.3).

Protein differential expression in normal tissues from HIPED for NKX1-1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKX1-1 Gene

Protein tissue co-expression partners for NKX1-1 Gene

SOURCE GeneReport for Unigene cluster for NKX1-1 Gene:


mRNA Expression by UniProt/SwissProt for NKX1-1 Gene:

Tissue specificity: Expressed in hemopoietic progenitor cells.

Evidence on tissue expression from TISSUES for NKX1-1 Gene

  • Bone marrow(4.1)
genes like me logo Genes that share expression patterns with NKX1-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKX1-1 Gene

Orthologs for NKX1-1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKX1-1 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia NKX1-1 34
  • 88 (a)
(Mus musculus)
Mammalia Nkx1-1 34
  • 85 (a)
(Pan troglodytes)
Mammalia NKX1-1 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia NKX1-1 34
  • 49 (a)
(Bos Taurus)
Mammalia -- 34
  • 29 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 22 (a)
(Gallus gallus)
Aves NKX1-1 34
  • 53 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25851 33
(Danio rerio)
Actinopterygii nkx1.2lb 34
  • 50 (a)
pnx 33
(Caenorhabditis elegans)
Secernentea ceh-1 34
  • 48 (a)
Species where no ortholog for NKX1-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKX1-1 Gene

Gene Tree for NKX1-1 (if available)
Gene Tree for NKX1-1 (if available)

Paralogs for NKX1-1 Gene

Paralogs for NKX1-1 Gene

(5) SIMAP similar genes for NKX1-1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NKX1-1: view

Variants for NKX1-1 Gene

Sequence variations from dbSNP and Humsavar for NKX1-1 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000186006 -- 1,407,067(-) C/T upstream_transcript_variant
rs1000586819 -- 1,402,959(-) C/A coding_sequence_variant, synonymous_variant
rs1000950688 -- 1,402,574(-) C/T downstream_transcript_variant
rs1000960523 -- 1,406,302(-) A/G coding_sequence_variant, synonymous_variant
rs1001637567 -- 1,406,321(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for NKX1-1 Gene

Variant ID Type Subtype PubMed ID
dgv853n67 CNV gain 20364138
nsv1073288 CNV deletion 25765185
nsv4197 CNV insertion 18451855
nsv593278 CNV loss 21841781
nsv593302 CNV loss 21841781
nsv822425 CNV loss 20364138
nsv950333 CNV deletion 24416366

Variation tolerance for NKX1-1 Gene

Gene Damage Index Score: 1.57; 30.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKX1-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKX1-1 Gene

Disorders for NKX1-1 Gene

Additional Disease Information for NKX1-1

No disorders were found for NKX1-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKX1-1 Gene

Publications for NKX1-1 Gene

  1. Identification of homeobox genes expressed in human haemopoietic progenitor cells. (PMID: 7518789) Moretti P … D'Andrea R (Gene 1994) 2 3 4 58
  2. Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3 58
  3. Ablation of Sax2 gene expression prevents diet-induced obesity. (PMID: 21126319) Simon R … Bergemann A (The FEBS journal 2011) 3 58
  4. Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis. (PMID: 17879320) Simon R … Bergemann AD (Developmental dynamics : an official publication of the American Association of Anatomists 2007) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for NKX1-1 Gene

Sources for NKX1-1 Gene

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