This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008] See more...

Aliases for NKTR Gene

Aliases for NKTR Gene

  • Natural Killer Cell Triggering Receptor 2 3 5
  • Natural-Killer Cells Cyclophilin-Related Protein 2 3 4
  • NK-Tumor Recognition Protein 2 3 4
  • NK-TR Protein 2 3 4
  • Natural Killer-Tumor Recognition Sequence 2 3
  • Peptidyl-Prolyl Cis-Trans Isomerase NKTR 3 4
  • EC 5.2.1.8 4 52
  • Rotamase 3 4
  • PPIase 3 4
  • Natural Killer Triggering Receptor 3
  • P104 3

External Ids for NKTR Gene

Previous GeneCards Identifiers for NKTR Gene

  • GC03P041946
  • GC03P041822
  • GC03P042461
  • GC03P042602
  • GC03P042617
  • GC03P042643

Summaries for NKTR Gene

Entrez Gene Summary for NKTR Gene

  • This gene encodes a membrane-anchored protein with a hydrophobic amino terminal domain and a cyclophilin-like PPIase domain. It is present on the surface of natural killer cells and facilitates their binding to targets. Its expression is regulated by IL2 activation of the cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NKTR Gene

NKTR (Natural Killer Cell Triggering Receptor) is a Protein Coding gene. Diseases associated with NKTR include Theileriasis and Opioid Abuse. Gene Ontology (GO) annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and cyclosporin A binding. An important paralog of this gene is PPIG.

UniProtKB/Swiss-Prot Summary for NKTR Gene

  • PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688).

Gene Wiki entry for NKTR Gene

Additional gene information for NKTR Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NKTR Gene

Genomics for NKTR Gene

GeneHancer (GH) Regulatory Elements for NKTR Gene

Promoters and enhancers for NKTR Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKTR on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NKTR

Top Transcription factor binding sites by QIAGEN in the NKTR gene promoter:
  • AP-4
  • HEN1

Genomic Locations for NKTR Gene

Genomic Locations for NKTR Gene
chr3:42,600,655-42,648,741
(GRCh38/hg38)
Size:
48,087 bases
Orientation:
Plus strand
chr3:42,642,106-42,690,233
(GRCh37/hg19)
Size:
48,128 bases
Orientation:
Plus strand

Genomic View for NKTR Gene

Genes around NKTR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKTR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKTR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKTR Gene

Proteins for NKTR Gene

  • Protein details for NKTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30414-NKTR_HUMAN
    Recommended name:
    NK-tumor recognition protein
    Protein Accession:
    P30414

    Protein attributes for NKTR Gene

    Size:
    1462 amino acids
    Molecular mass:
    165677 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for NKTR Gene

neXtProt entry for NKTR Gene

Selected DME Specific Peptides for NKTR Gene

P30414:
  • FMIQGGD
  • TNGSQFF
  • GGESIYG

Post-translational modifications for NKTR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for NKTR Gene

Gene Families for NKTR Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for NKTR Gene

Blocks:
  • Peptidyl-prolyl cis-trans isomerase, cyclophilin type
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKTR Gene

GenScript: Design optimal peptide antigens:
  • Peptidyl-prolyl cis-trans isomerase (A8K7K2_HUMAN)
  • Peptidyl-prolyl cis-trans isomerase (C9JMM5_HUMAN)
  • Natural-killer cells cyclophilin-related protein (NKTR_HUMAN)
genes like me logo Genes that share domains with NKTR: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NKTR Gene

Function for NKTR Gene

Molecular function for NKTR Gene

UniProtKB/Swiss-Prot Function:
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Component of a putative tumor-recognition complex involved in the function of NK cells (PubMed:8421688).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by cyclosporin A (CsA).
GENATLAS Biochemistry:
natural killer triggering receptor

Enzyme Numbers (IUBMB) for NKTR Gene

Phenotypes From GWAS Catalog for NKTR Gene

Gene Ontology (GO) - Molecular Function for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003755 peptidyl-prolyl cis-trans isomerase activity IEA,IDA 20676357
GO:0016018 cyclosporin A binding TAS,IDA 20676357
GO:0016853 isomerase activity IEA --
GO:0051082 unfolded protein binding IBA 21873635
genes like me logo Genes that share ontologies with NKTR: view
genes like me logo Genes that share phenotypes with NKTR: view

Animal Model Products

  • Taconic Biosciences Mouse Models for NKTR

Clone Products

  • Addgene plasmids for NKTR

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKTR Gene

Localization for NKTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKTR Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKTR gene
Compartment Confidence
plasma membrane 4
nucleus 4
cytosol 3
mitochondrion 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA,IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with NKTR: view

Pathways & Interactions for NKTR Gene

PathCards logo

SuperPathways for NKTR Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IDA 20676357
GO:0006457 protein folding IEA --
GO:0042026 protein refolding IBA 21873635
genes like me logo Genes that share ontologies with NKTR: view

No data available for Pathways by source and SIGNOR curated interactions for NKTR Gene

Drugs & Compounds for NKTR Gene

No Compound Related Data Available

Transcripts for NKTR Gene

mRNA/cDNA for NKTR Gene

5 REFSEQ mRNAs :
20 NCBI additional mRNA sequence :
19 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for NKTR

Alternative Splicing Database (ASD) splice patterns (SP) for NKTR Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^
SP1: - - -
SP2: - -
SP3:
SP4:
SP5: -
SP6: - -
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 17a · 17b ^ 18a · 18b · 18c
SP1:
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for NKTR Gene

GeneLoc Exon Structure for
NKTR

Expression for NKTR Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NKTR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NKTR Gene

This gene is overexpressed in Heart (45.8) and Cerebrospinal fluid (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NKTR Gene



Protein tissue co-expression partners for NKTR Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NKTR

SOURCE GeneReport for Unigene cluster for NKTR Gene:

Hs.529509

Evidence on tissue expression from TISSUES for NKTR Gene

  • Gall bladder(5)
  • Blood(4.8)
  • Liver(4.3)
  • Nervous system(3.8)
  • Intestine(3.6)
genes like me logo Genes that share expression patterns with NKTR: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKTR Gene

Orthologs for NKTR Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NKTR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKTR 31 30
  • 99.52 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NKTR 31 30
  • 90.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NKTR 31 30
  • 90.18 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 83 (a)
OneToMany
-- 31
  • 53 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Nktr 17 31 30
  • 81.89 (n)
rat
(Rattus norvegicus)
Mammalia Nktr 30
  • 79.27 (n)
oppossum
(Monodelphis domestica)
Mammalia NKTR 31
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKTR 31 30
  • 68.08 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKTR 31
  • 64 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii nktr 31
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Moca-cyp 31
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cyp-8 32
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CPR6 31
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3359 31
  • 51 (a)
OneToMany
Species where no ortholog for NKTR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKTR Gene

ENSEMBL:
Gene Tree for NKTR (if available)
TreeFam:
Gene Tree for NKTR (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NKTR: view image

Paralogs for NKTR Gene

(25) SIMAP similar genes for NKTR Gene using alignment to 3 proteins:

  • NKTR_HUMAN
  • A8K7K2_HUMAN
  • C9JMM5_HUMAN
genes like me logo Genes that share paralogs with NKTR: view

Variants for NKTR Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NKTR Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
770519 Benign: not provided 42,633,618(+) T/G MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT
rs33969824 - p.Leu861Val
rs34897686 - p.Met1182Thr
rs35726114 - p.Val271Gly
rs35770315 - p.Ser935Leu

Additional dbSNP identifiers (rs#s) for NKTR Gene

Structural Variations from Database of Genomic Variants (DGV) for NKTR Gene

Variant ID Type Subtype PubMed ID
nsv3781 CNV insertion 18451855

Variation tolerance for NKTR Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKTR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKTR

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKTR Gene

Disorders for NKTR Gene

MalaCards: The human disease database

(3) MalaCards diseases for NKTR Gene - From: DISEASES

Disorder Aliases PubMed IDs
theileriasis
  • infection by theileria
opioid abuse
  • opioid-related disorders
babesiosis
  • babesiasis
- elite association - COSMIC cancer census association via MalaCards
Search NKTR in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NKTR

genes like me logo Genes that share disorders with NKTR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKTR Gene

Publications for NKTR Gene

  1. Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases. (PMID: 20676357) Davis TL … Dhe-Paganon S (PLoS biology 2010) 3 4 54
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  3. Expression of the NK-TR gene is required for NK-like activity in human T cells. (PMID: 8144875) Chambers CA … Roder J (Journal of immunology (Baltimore, Md. : 1950) 1994) 2 3 54
  4. A cyclophilin-related protein involved in the function of natural killer cells. (PMID: 8421688) Anderson SK … Ortaldo JR (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 54
  5. IL-2 regulates the expression of the NK-TR gene via an alternate RNA splicing mechanism. (PMID: 8413330) Rinfret A … Anderson SK (Molecular immunology 1993) 3 23 54

Products for NKTR Gene

Sources for NKTR Gene