Aliases for NKRF Gene
External Ids for NKRF Gene
Previous GeneCards Identifiers for NKRF Gene
This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for NKRF Gene
NKRF (NFKB Repressing Factor) is a Protein Coding gene. Diseases associated with NKRF include Angiokeratoma Of Mibelli and Retinitis Pigmentosa 46. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is CDKN2AIP.
UniProtKB/Swiss-Prot Summary for NKRF Gene
Interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.