Aliases for NKPD1 Gene

Aliases for NKPD1 Gene

  • NTPase KAP Family P-Loop Domain Containing 1 2 3 5
  • NTPase KAP Family P-Loop Domain-Containing Protein 1 3 4
  • NTPase, KAP Family P-Loop Domain Containing 1 2

External Ids for NKPD1 Gene

Previous GeneCards Identifiers for NKPD1 Gene

  • GC19M050347
  • GC19M050348
  • GC19M045655
  • GC19M042083

Summaries for NKPD1 Gene

GeneCards Summary for NKPD1 Gene

NKPD1 (NTPase KAP Family P-Loop Domain Containing 1) is a Protein Coding gene.

Additional gene information for NKPD1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NKPD1 Gene

Genomics for NKPD1 Gene

GeneHancer (GH) Regulatory Elements for NKPD1 Gene

Promoters and enhancers for NKPD1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045160 Enhancer 0.9 Ensembl ENCODE 750.6 +1.2 1240 2.4 CTCF MNT MYC REST CTBP1 ZFX PKNOX1 SAP130 POLR2A DPF2 NKPD1 PPP1R37 ZNF226 ZNF235 ZNF227 QPCTL ZNF180 ENSG00000270679 ERCC2 ZNF112
GH19J045163 Enhancer 0.8 ENCODE 758.6 -1.7 -1687 1.4 RBPJ NFYC RELA MNT ELF3 ZNF687 CREM SP5 POLR2A KAT8 NKPD1 PPP1R37 TRAPPC6A MARK4
GH19J045089 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 7.2 +70.1 70064 6 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF ZBTB6 RBPJ POLR2A USF2 PPP1R37 GEMIN7-AS1 lnc-GEMIN7-1 ZNF225 ZNF227 ZNF226 ZNF235 ZNF180 ENSG00000186019 GEMIN7
GH19J045096 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +61.5 61522 9.8 ZBTB6 RBPJ SMARCE1 USF2 NR2F6 HLF L3MBTL2 MNT ZNF148 ELF3 GEMIN7 ENSG00000270679 FOSB ZNF296 PPP1R37 RELB CLASRP ZNF225 NKPD1 GEMIN7-AS1
GH19J045133 Enhancer 1.1 Ensembl ENCODE dbSUPER 7.1 +26.0 26040 6.4 SP1 USF2 RELA POLR2A SP7 ZNF687 CREM ZBTB33 IKZF1 GLIS2 ENSG00000267044 DMPK PPP1R37 RELB CKM CLASRP NKPD1 piR-53819-005 MARK4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKPD1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKPD1 gene promoter:
  • AP-1
  • AP-4
  • c-Myc
  • Elk-1
  • Ik-2
  • Max1
  • POU3F2

Genomic Locations for NKPD1 Gene

Genomic Locations for NKPD1 Gene
chr19:45,149,111-45,162,841
(GRCh38/hg38)
Size:
13,731 bases
Orientation:
Minus strand
chr19:45,653,008-45,663,408
(GRCh37/hg19)
Size:
10,401 bases
Orientation:
Minus strand

Genomic View for NKPD1 Gene

Genes around NKPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKPD1 Gene

Proteins for NKPD1 Gene

  • Protein details for NKPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q17RQ9-NKPD1_HUMAN
    Recommended name:
    NTPase KAP family P-loop domain-containing protein 1
    Protein Accession:
    Q17RQ9
    Secondary Accessions:
    • B7ZLG6
    • D6RH15
    • Q8N2A2

    Protein attributes for NKPD1 Gene

    Size:
    610 amino acids
    Molecular mass:
    67780 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC03547.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

neXtProt entry for NKPD1 Gene

Post-translational modifications for NKPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKPD1 Gene

No data available for DME Specific Peptides for NKPD1 Gene

Domains & Families for NKPD1 Gene

Gene Families for NKPD1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NKPD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKPD1 Gene

GenScript: Design optimal peptide antigens:
  • NTPase KAP family P-loop domain-containing protein 1 (NKPD1_HUMAN)
genes like me logo Genes that share domains with NKPD1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NKPD1 Gene

Function for NKPD1 Gene

Phenotypes From GWAS Catalog for NKPD1 Gene

genes like me logo Genes that share phenotypes with NKPD1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKPD1 Gene

Localization for NKPD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKPD1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKPD1 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for NKPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKPD1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKPD1 Gene

Pathways & Interactions for NKPD1 Gene

PathCards logo

SuperPathways for NKPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKPD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKPD1 Gene

Drugs & Compounds for NKPD1 Gene

No Compound Related Data Available

Transcripts for NKPD1 Gene

mRNA/cDNA for NKPD1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKPD1 Gene

No ASD Table

Relevant External Links for NKPD1 Gene

GeneLoc Exon Structure for
NKPD1
ECgene alternative splicing isoforms for
NKPD1

Expression for NKPD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKPD1 Gene

mRNA differential expression in normal tissues according to GTEx for NKPD1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x18.6) and Skin - Sun Exposed (Lower leg) (x16.1).

Protein differential expression in normal tissues from HIPED for NKPD1 Gene

This gene is overexpressed in Serum (56.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKPD1 Gene



Protein tissue co-expression partners for NKPD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NKPD1 Gene:

NKPD1

SOURCE GeneReport for Unigene cluster for NKPD1 Gene:

Hs.299256

Evidence on tissue expression from TISSUES for NKPD1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with NKPD1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKPD1 Gene

Orthologs for NKPD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKPD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKPD1 33 32
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NKPD1 33 32
  • 87.1 (n)
OneToOne
cow
(Bos Taurus)
Mammalia NKPD1 33 32
  • 86.19 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nkpd1 17 33 32
  • 83.15 (n)
rat
(Rattus norvegicus)
Mammalia Nkpd1 32
  • 83.15 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia NKPD1 33
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NKPD1 33
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489552 32
  • 52.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC561946 32
  • 45.22 (n)
BX119916.1 33
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 31 (a)
OneToMany
-- 33
  • 28 (a)
OneToMany
-- 33
  • 21 (a)
OneToMany
Species where no ortholog for NKPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKPD1 Gene

ENSEMBL:
Gene Tree for NKPD1 (if available)
TreeFam:
Gene Tree for NKPD1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NKPD1: view image

Paralogs for NKPD1 Gene

No data available for Paralogs for NKPD1 Gene

Variants for NKPD1 Gene

Sequence variations from dbSNP and Humsavar for NKPD1 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000155211 -- 45,155,371(-) G/A intron_variant
rs1000200920 -- 45,152,931(-) T/C coding_sequence_variant, synonymous_variant
rs1000505161 -- 45,157,519(-) C/G intron_variant
rs1000537655 -- 45,157,793(-) C/T intron_variant
rs1000690759 -- 45,161,107(-) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NKPD1 Gene

Variant ID Type Subtype PubMed ID
nsv520051 CNV loss 19592680
nsv522341 CNV loss 19592680
nsv833842 CNV loss 17160897
nsv833843 CNV loss 17160897
nsv953587 CNV deletion 24416366

Variation tolerance for NKPD1 Gene

Gene Damage Index Score: 6.12; 75.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKPD1 Gene

Human Gene Mutation Database (HGMD)
NKPD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKPD1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKPD1 Gene

Disorders for NKPD1 Gene

Additional Disease Information for NKPD1

No disorders were found for NKPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKPD1 Gene

Publications for NKPD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 2 3 4 56
  2. Nonsynonymous Variation in NKPD1 Increases Depressive Symptoms in European Populations. (PMID: 27745872) Amin N … van Duijn CM (Biological psychiatry 2017) 3 56
  3. Altered membrane NTPase activity in Lesch-Nyhan disease fibroblasts: comparison with HPRT knockout mice and HPRT-deficient cell lines. (PMID: 15935074) Pinto CS … Seifert R (Journal of neurochemistry 2005) 3 56
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 56
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56

Products for NKPD1 Gene

Sources for NKPD1 Gene