Aliases for NKIRAS2 Gene
External Ids for NKIRAS2 Gene
Previous GeneCards Identifiers for NKIRAS2 Gene
GeneCards Summary for NKIRAS2 Gene
NKIRAS2 (NFKB Inhibitor Interacting Ras Like 2) is a Protein Coding gene. Diseases associated with NKIRAS2 include Diffuse Lipomatosis. Among its related pathways are NF-KappaB Family Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is NKIRAS1.
UniProtKB/Swiss-Prot Summary for NKIRAS2 Gene
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity).