Aliases for NKG7 Gene

Aliases for NKG7 Gene

  • Natural Killer Cell Granule Protein 7 2 3 5
  • GMP-17 2 3 4
  • GIG1 2 3 4
  • Natural Killer Cell Group 7 Sequence 2 3
  • Granule Membrane Protein Of 17 KDa 3 4
  • Natural Killer Cell Protein 7 3 4
  • G-CSF-Induced Gene 1 Protein 3 4
  • Granule Membrane Protein 17 2 3
  • GIG-1 Protein 3 4
  • Protein NKG7 3 4
  • P15-TIA-1 3 4
  • NKG7 5

External Ids for NKG7 Gene

Previous GeneCards Identifiers for NKG7 Gene

  • GC19M052505
  • GC19M052236
  • GC19M056550
  • GC19M056566
  • GC19M051874
  • GC19M048206

Summaries for NKG7 Gene

GeneCards Summary for NKG7 Gene

NKG7 (Natural Killer Cell Granule Protein 7) is a Protein Coding gene. An important paralog of this gene is LIM2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NKG7 Gene

Genomics for NKG7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NKG7 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKG7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NKG7

Top Transcription factor binding sites by QIAGEN in the NKG7 gene promoter:
  • CP2
  • GATA-1
  • HNF-4alpha1
  • HSF2
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • Pax-6
  • RelA
  • Roaz

Genomic Locations for NKG7 Gene

Latest Assembly
1,096 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
1,035 bases
Minus strand

(GRCh37/hg19 by Ensembl)
1,110 bases
Minus strand

Genomic View for NKG7 Gene

Genes around NKG7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKG7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKG7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKG7 Gene

Proteins for NKG7 Gene

  • Protein details for NKG7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein NKG7
    Protein Accession:

    Protein attributes for NKG7 Gene

    165 amino acids
    Molecular mass:
    17665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NKG7 Gene

Post-translational modifications for NKG7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NKG7 Gene

Domains & Families for NKG7 Gene

Gene Families for NKG7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for NKG7 Gene

Suggested Antigen Peptide Sequences for NKG7 Gene

GenScript: Design optimal peptide antigens:
  • p15-TIA-1 (NKG7_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PMP-22/EMP/MP20 family.
  • Belongs to the PMP-22/EMP/MP20 family.
genes like me logo Genes that share domains with NKG7: view

Function for NKG7 Gene

Molecular function for NKG7 Gene

UniProtKB/Swiss-Prot Induction:
GENATLAS Biochemistry:
natural killer,group 7 sequence

Phenotypes From GWAS Catalog for NKG7 Gene

Gene Ontology (GO) - Molecular Function for NKG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NKG7: view
genes like me logo Genes that share phenotypes with NKG7: view

Animal Models for NKG7 Gene

MGI Knock Outs for NKG7:
  • Nkg7 Nkg7<tm1.1(KOMP)Vlcg>

miRNA for NKG7 Gene

miRTarBase miRNAs that target NKG7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKG7

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKG7 Gene

Localization for NKG7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKG7 Gene

Cell membrane. Multi-pass membrane protein. Cytoplasmic granule membrane. Multi-pass membrane protein. Note=Cytoplasmic granules of cytolytic T-lymphocytes, NK cells, and neutrophils.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKG7 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NKG7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0005887 integral component of plasma membrane TAS 8458737
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKG7: view

Pathways & Interactions for NKG7 Gene

PathCards logo

SuperPathways for NKG7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKG7 Gene


No data available for Pathways by source and SIGNOR curated interactions for NKG7 Gene

Drugs & Compounds for NKG7 Gene

No Compound Related Data Available

Transcripts for NKG7 Gene

mRNA/cDNA for NKG7 Gene

5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKG7

Alternative Splicing Database (ASD) splice patterns (SP) for NKG7 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b
SP2: -
SP3: - -

Relevant External Links for NKG7 Gene

GeneLoc Exon Structure for

Expression for NKG7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NKG7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NKG7 Gene

This gene is overexpressed in Whole Blood (x44.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NKG7

SOURCE GeneReport for Unigene cluster for NKG7 Gene:


mRNA Expression by UniProt/SwissProt for NKG7 Gene:

Tissue specificity: Expressed in activated T-cells, in kidney, liver, lung and pancreas. Not expressed in brain, heart, or skeletal muscle. Expressed at high levels in TCR gamma delta-expressing CTL clones, and in some TCR alpha beta-expressing CTL clones (both CD4+ and CD8+), but is not expressed in other TCR alpha beta-expressing CTL clones and in cell lines representing B-cells, monocytes, and myeloid cells.

Evidence on tissue expression from TISSUES for NKG7 Gene

  • Blood(4.6)
  • Bone marrow(2.9)
  • Lymph node(2.8)
  • Spleen(2.7)
  • Intestine(2.4)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with NKG7: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKG7 Gene

Orthologs for NKG7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKG7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NKG7 30 31
  • 97.88 (n)
(Canis familiaris)
Mammalia NKG7 30 31
  • 77.78 (n)
(Rattus norvegicus)
Mammalia Nkg7 30
  • 76.57 (n)
(Mus musculus)
Mammalia Nkg7 30 17 31
  • 75.35 (n)
(Bos Taurus)
Mammalia NKG7 31
  • 64 (a)
(Monodelphis domestica)
Mammalia NKG7 31
  • 52 (a)
(Anolis carolinensis)
Reptilia NKG7 31
  • 35 (a)
Species where no ortholog for NKG7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for NKG7 Gene

Gene Tree for NKG7 (if available)
Gene Tree for NKG7 (if available)
Evolutionary constrained regions (ECRs) for NKG7: view image

Paralogs for NKG7 Gene

Paralogs for NKG7 Gene

genes like me logo Genes that share paralogs with NKG7: view

Variants for NKG7 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NKG7 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs111589366 Benign: not provided 51,372,311(-) A/T
rs34131521 Benign: not provided 51,372,042(-) T/C
NM_005601.4(NKG7):c.337A>G (p.Thr113Ala)

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NKG7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NKG7 Gene

Variant ID Type Subtype PubMed ID
nsv1140251 OTHER inversion 24896259

Variation tolerance for NKG7 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKG7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKG7 Gene

Disorders for NKG7 Gene

Additional Disease Information for NKG7

No disorders were found for NKG7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKG7 Gene

Publications for NKG7 Gene

  1. Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells. (PMID: 8458737) Turman MA … Houchins JP (Human immunology 1993) 2 3 4 23
  2. Molecular cloning and characterization of G-CSF induced gene cDNA. (PMID: 7510105) Shimane M … Asano S (Biochemical and biophysical research communications 1994) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. (PMID: 8570616) Medley QG … Anderson P (Proceedings of the National Academy of Sciences of the United States of America 1996) 4 23
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for NKG7 Gene

Sources for NKG7 Gene