Aliases for NKD1 Gene
External Ids for NKD1 Gene
Previous GeneCards Identifiers for NKD1 Gene
In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
GeneCards Summary for NKD1 Gene
NKD1 (Naked Cuticle Homolog 1) is a Protein Coding gene. Diseases associated with NKD1 include Chronic Nk-Cell Lymphocytosis. Among its related pathways are Presenilin action in Notch and Wnt signaling and Wnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene include calcium ion binding and PDZ domain binding. An important paralog of this gene is NKD2.
UniProtKB/Swiss-Prot for NKD1 Gene
Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity.