Aliases for NKAPL Gene

Aliases for NKAPL Gene

  • NFKB Activating Protein Like 2 3 5
  • NKAP-Like Protein 3 4
  • C6orf194 3 4
  • Chromosome 6 Open Reading Frame 194 2
  • NFKB Activating Protein-Like 2
  • BA424I5.1 3

External Ids for NKAPL Gene

Previous HGNC Symbols for NKAPL Gene

  • C6orf194

Previous GeneCards Identifiers for NKAPL Gene

  • GC06P028336
  • GC06P028227
  • GC06P028037

Summaries for NKAPL Gene

GeneCards Summary for NKAPL Gene

NKAPL (NFKB Activating Protein Like) is a Protein Coding gene. An important paralog of this gene is NKAP.

UniProtKB/Swiss-Prot Summary for NKAPL Gene

  • Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.

Additional gene information for NKAPL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NKAPL Gene

Genomics for NKAPL Gene

GeneHancer (GH) Regulatory Elements for NKAPL Gene

Promoters and enhancers for NKAPL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKAPL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKAPL gene promoter:
  • AREB6
  • Brachyury
  • c-Ets-1
  • GATA-1
  • GR-alpha
  • GR-beta
  • LCR-F1
  • p300
  • p53
  • Roaz

Genomic Locations for NKAPL Gene

Genomic Locations for NKAPL Gene
chr6:28,259,297-28,260,958
(GRCh38/hg38)
Size:
1,662 bases
Orientation:
Plus strand
chr6:28,227,098-28,228,736
(GRCh37/hg19)
Size:
1,639 bases
Orientation:
Plus strand

Genomic View for NKAPL Gene

Genes around NKAPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPL Gene

Proteins for NKAPL Gene

  • Protein details for NKAPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5M9Q1-NKAPL_HUMAN
    Recommended name:
    NKAP-like protein
    Protein Accession:
    Q5M9Q1
    Secondary Accessions:
    • Q3MIV1
    • Q9H4Q7

    Protein attributes for NKAPL Gene

    Size:
    402 amino acids
    Molecular mass:
    46312 Da
    Quaternary structure:
    • Interacts with RBPJ, CIR1 and HDAC3.

neXtProt entry for NKAPL Gene

Post-translational modifications for NKAPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NKAPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NKAPL Gene

Domains & Families for NKAPL Gene

Gene Families for NKAPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NKAPL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for NKAPL Gene

GenScript: Design optimal peptide antigens:
  • NKAP-like protein (NKAPL_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5M9Q1

UniProtKB/Swiss-Prot:

NKAPL_HUMAN :
  • Belongs to the NKAP family.
Family:
  • Belongs to the NKAP family.
genes like me logo Genes that share domains with NKAPL: view

Function for NKAPL Gene

Molecular function for NKAPL Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.

Phenotypes From GWAS Catalog for NKAPL Gene

Gene Ontology (GO) - Molecular Function for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with NKAPL: view
genes like me logo Genes that share phenotypes with NKAPL: view

Animal Models for NKAPL Gene

MGI Knock Outs for NKAPL:
  • Nkapl Nkapl<tm1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKAPL Gene

Localization for NKAPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAPL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAPL gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with NKAPL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKAPL Gene

Pathways & Interactions for NKAPL Gene

PathCards logo

SuperPathways for NKAPL Gene

No Data Available

Interacting Proteins for NKAPL Gene

Gene Ontology (GO) - Biological Process for NKAPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007219 Notch signaling pathway IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
GO:0045892 negative regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with NKAPL: view

No data available for Pathways by source and SIGNOR curated interactions for NKAPL Gene

Drugs & Compounds for NKAPL Gene

No Compound Related Data Available

Transcripts for NKAPL Gene

mRNA/cDNA for NKAPL Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(50) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPL Gene

No ASD Table

Relevant External Links for NKAPL Gene

GeneLoc Exon Structure for
NKAPL
ECgene alternative splicing isoforms for
NKAPL

Expression for NKAPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKAPL Gene

mRNA differential expression in normal tissues according to GTEx for NKAPL Gene

This gene is overexpressed in Testis (x13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKAPL Gene



NURSA nuclear receptor signaling pathways regulating expression of NKAPL Gene:

NKAPL

SOURCE GeneReport for Unigene cluster for NKAPL Gene:

Hs.48787

Evidence on tissue expression from TISSUES for NKAPL Gene

  • Nervous system(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with NKAPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAPL Gene

Orthologs for NKAPL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NKAPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKAPL 33 32
  • 93.98 (n)
OneToOne
dog
(Canis familiaris)
Mammalia NKAPL 33 32
  • 74.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Nkapl 17 33 32
  • 72.52 (n)
rat
(Rattus norvegicus)
Mammalia Nkapl 32
  • 71.1 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 64 (a)
OneToMany
cow
(Bos Taurus)
Mammalia NKAPL 33
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves NKAP 33 32
  • 64.74 (n)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 33
  • 58 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii nkap 33
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6066 33
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea let-504 33
  • 24 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4484 32
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 40 (a)
OneToMany
Species where no ortholog for NKAPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for NKAPL Gene

ENSEMBL:
Gene Tree for NKAPL (if available)
TreeFam:
Gene Tree for NKAPL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NKAPL: view image

Paralogs for NKAPL Gene

Paralogs for NKAPL Gene

(1) SIMAP similar genes for NKAPL Gene using alignment to 1 proteins:

  • NKAPL_HUMAN
genes like me logo Genes that share paralogs with NKAPL: view

Variants for NKAPL Gene

Sequence variations from dbSNP and Humsavar for NKAPL Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001245941 -- 28,257,706(+) A/G upstream_transcript_variant
rs1001676006 -- 28,258,016(+) C/T upstream_transcript_variant
rs1002705275 -- 28,260,800(+) G/A 3_prime_UTR_variant
rs1003970067 -- 28,259,258(+) C/T upstream_transcript_variant
rs1005643066 -- 28,261,150(+) T/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NKAPL Gene

Variant ID Type Subtype PubMed ID
nsv830620 CNV loss 17160897
nsv950146 CNV duplication 24416366

Variation tolerance for NKAPL Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.59; 89.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKAPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKAPL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAPL Gene

Disorders for NKAPL Gene

Additional Disease Information for NKAPL

No disorders were found for NKAPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPL Gene

Publications for NKAPL Gene

  1. Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue WH … Zhang D (Nature genetics 2011) 3 43 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Association between NF-κB Pathway Gene Variants and sICAM1 Levels in Taiwanese. (PMID: 28095483) Wu S … Ko YL (PloS one 2017) 3 56

Products for NKAPL Gene

Sources for NKAPL Gene