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Aliases for NKAPL Gene
Aliases for NKAPL Gene
External Ids for NKAPL Gene
- HGNC: 21584
- Entrez Gene: 222698
- Ensembl: ENSG00000189134
- UniProtKB: Q5M9Q1
Previous HGNC Symbols for NKAPL Gene
- C6orf194
Previous GeneCards Identifiers for NKAPL Gene
- GC06P028336
- GC06P028227
- GC06P028037
Summaries for NKAPL Gene
GeneCards Summary for NKAPL Gene
NKAPL (NFKB Activating Protein Like) is a Protein Coding gene. An important paralog of this gene is NKAP.
UniProtKB/Swiss-Prot Summary for NKAPL Gene
-
Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.
Additional gene information for NKAPL Gene
- HGNC(21584)
- Entrez Gene(222698)
- Ensembl(ENSG00000189134)
- UniProtKB(Q5M9Q1)
- Open Targets Platform(ENSG00000189134)
- Monarch Initiative
- Search for NKAPL at DataMed
- Search for NKAPL at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NKAPL Gene
Genomics for NKAPL Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for NKAPL Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around NKAPL on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NKAPL
- Top Transcription factor binding sites by QIAGEN in the NKAPL gene promoter:
-
- AREB6
- Brachyury
- c-Ets-1
- GATA-1
- GR-alpha
- GR-beta
- LCR-F1
- p300
- p53
- Roaz
Genomic Locations for NKAPL Gene
Genomic Locations for NKAPL Gene
- chr6:28,259,297-28,260,958
- (GRCh38/hg38)
- Size:
- 1,662 bases
- Orientation:
- Plus strand
- chr6:28,227,098-28,228,736
- (GRCh37/hg19)
- Size:
- 1,639 bases
- Orientation:
- Plus strand
Genomic View for NKAPL Gene
Genes around NKAPL on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p22.1 by HGNC
- 6p22.1 by Entrez Gene
- 6p22.1 by Ensembl
NKAPL Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for NKAPL Gene
Proteins for NKAPL Gene
-
Protein details for NKAPL Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5M9Q1-NKAPL_HUMAN
- Recommended name:
- NKAP-like protein
- Protein Accession:
- Q5M9Q1
- Q3MIV1
- Q9H4Q7
Protein attributes for NKAPL Gene
- Size:
- 402 amino acids
- Molecular mass:
- 46312 Da
- Quaternary structure:
-
- Interacts with RBPJ, CIR1 and HDAC3.
Protein Expression for NKAPL Gene
Post-translational modifications for NKAPL Gene
Other Protein References for NKAPL Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-NKAPL (aa 179-228) polyclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for NKAPL
- Novus Biologicals Antibodies for NKAPL
-
Abcam antibodies for NKAPL
- Invitrogen Antibodies for NKAPL (AFLGC-NKAPL)
- antibodies-online: Show 23 available NKAPL Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for NKAPL
- Search Origene for MassSpec and Protein Over-expression Lysates for NKAPL
- Origene Custom Protein Services for NKAPL
- Novus Biologicals lysates for NKAPL
No data available for DME Specific Peptides for NKAPL Gene
Domains & Families for NKAPL Gene
Gene Families for NKAPL Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for NKAPL Gene
- GenScript: Design optimal peptide antigens:
-
- NKAP-like protein (NKAPL_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q5M9Q1- Family:
-
- Belongs to the NKAP family.
Function for NKAPL Gene
Molecular function for NKAPL Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis.
Phenotypes From GWAS Catalog for NKAPL Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for NKAPL Gene
- MGI mutant phenotypes for NKAPL:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for NKAPL:
Animal Models for NKAPL Gene
- MGI Knock Outs for NKAPL:
-
- Nkapl Nkapl<tm1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NKAPL - Select products 50% OFF >
- * NKAPL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NKAPL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NKAPL
-
Santa Cruz Biotechnology (SCBT) CRISPR for NKAPL
miRNA for NKAPL Gene
- miRTarBase miRNAs that target NKAPL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NKAPL
- Browse OriGene Inhibitory RNA Products For NKAPL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPL
Clone Products
- Applied Biological Materials (abm): Clones for NKAPL - Select products 50% OFF >
- * NKAPL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NKAPL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NKAPL
Cell Line Products
-
Horizon Cell Lines for NKAPL
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKAPL Gene
Localization for NKAPL Gene
Subcellular locations from UniProtKB/Swiss-Prot for NKAPL Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for NKAPL Gene
Pathways & Interactions for NKAPL Gene
Interacting Proteins for NKAPL Gene
Selected Interacting proteins:
Q5M9Q1-NKAPL_HUMAN
ENSP00000345716
for NKAPL Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for NKAPL
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007219 | Notch signaling pathway | IEA | -- |
| GO:0007283 | spermatogenesis | IEA | -- |
| GO:0030154 | cell differentiation | IEA | -- |
| GO:0045892 | negative regulation of transcription, DNA-templated | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for NKAPL Gene
Transcripts for NKAPL Gene
mRNA/cDNA for NKAPL Gene
- 1 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343684 1662 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for NKAPL - Select products 50% OFF >
- * NKAPL CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for NKAPL
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NKAPL
-
Santa Cruz Biotechnology (SCBT) CRISPR for NKAPL
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NKAPL
- Browse OriGene Inhibitory RNA Products For NKAPL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPL
Clone Products
- Applied Biological Materials (abm): Clones for NKAPL - Select products 50% OFF >
- * NKAPL as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for NKAPL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NKAPL
Relevant External Links for NKAPL Gene
- GeneLoc Exon Structure for
- NKAPL
Expression for NKAPL Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for NKAPL Gene
This gene is overexpressed in Testis (x13.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NKAPL Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NKAPL
SOURCE GeneReport for Unigene cluster for NKAPL Gene:
Hs.48787Evidence on tissue expression from TISSUES for NKAPL Gene
- Nervous system(4.3)
- Lung(4)
Primer Products
-
OriGene qPCR primer pairs for NKAPL
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAPL Gene
Orthologs for NKAPL Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | NKAPL 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | NKAPL 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Nkapl 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Nkapl 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | NKAPL 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | NKAP 30 31 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | nkap 31 |
|
OneToMany | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6066 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | let-504 31 |
|
OneToMany | |
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.4484 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for NKAPL was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for NKAPL Gene
- ENSEMBL:
- Gene Tree for NKAPL (if available)
- TreeFam:
- Gene Tree for NKAPL (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for NKAPL: view image
Paralogs for NKAPL Gene
Variants for NKAPL Gene
Residual Variation Intolerance Score:
93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.59;
89.02% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for NKAPL Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- NKAPL
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAPL Gene
Disorders for NKAPL Gene
Additional Disease Information for NKAPL
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for NKAPL Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPL Gene
Publications for NKAPL Gene
- Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. (PMID: 22037552) Yue WH … Zhang D (Nature genetics 2011) 3 41
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
- PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
ExternalLinks
Products for NKAPL Gene
- Custom Antibody ServicesOriGene Antibodies for NKAPL
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for NKAPL
- Search Origene for MassSpec and Protein Over-expression Lysates for NKAPL
- Origene Custom Protein Services for NKAPL
- Origene shrna, sirna, and RNAi products in human, mouse, rat for NKAPL
- Browse OriGene Inhibitory RNA Products For NKAPL
- OriGene qPCR primer pairs for NKAPL
- OriGene CRISPR knockouts for NKAPL
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For NKAPL
- Sino Biological Human cDNA Clone for NKAPL
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for NKAPL
- Novus Biologicals lysates for NKAPL
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for NKAPL
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for NKAPL (AFLGC-NKAPL)
- VectorBuilder Custom and pre-made DNA vectors for NKAPL (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for NKAPL (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for NKAPL (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for NKAPL CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for NKAPL
- antibodies-online: Show 23 available NKAPL Antibodies ranked by validation data
- antibodies-online: Search results for available NKAPL related products ranked by validation data
- antibodies-online: Search results for available NKAPL related products ranked by validation data
- Horizon Cell Lines for NKAPL
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for NKAPL
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for NKAPL
- Search GeneCopoeia for miRNA 3'UTR Target clone products for NKAPL
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPL
Sources for NKAPL Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB