Aliases for NKAPD1 Gene

Aliases for NKAPD1 Gene

  • NKAP Domain Containing 1 2 3 5
  • NKAP Domain Containing Protein 1 3 4
  • Uncharacterized Protein NKAPD1 3 4
  • C11orf57 3 4
  • Chromosome 11 Open Reading Frame 57 2
  • Uncharacterized Protein C11orf57 3
  • FLJ10726 2
  • NKAPD1 5

External Ids for NKAPD1 Gene

Previous HGNC Symbols for NKAPD1 Gene

  • C11orf57

Summaries for NKAPD1 Gene

GeneCards Summary for NKAPD1 Gene

NKAPD1 (NKAP Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NKAPD1 Gene

Genomics for NKAPD1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NKAPD1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NKAPD1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NKAPD1

Genomic Locations for NKAPD1 Gene

Latest Assembly
chr11:112,074,086-112,085,150
(GRCh38/hg38)
Size:
11,065 bases
Orientation:
Plus strand

Previous Assembly
chr11:111,945,023-111,955,874
(GRCh37/hg19 by Entrez Gene)
Size:
10,852 bases
Orientation:
Plus strand

chr11:111,944,810-111,955,874
(GRCh37/hg19 by Ensembl)
Size:
11,065 bases
Orientation:
Plus strand

Genomic View for NKAPD1 Gene

Genes around NKAPD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAPD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAPD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAPD1 Gene

Proteins for NKAPD1 Gene

  • Protein details for NKAPD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZUT1-NKAP1_HUMAN
    Recommended name:
    Uncharacterized protein NKAPD1
    Protein Accession:
    Q6ZUT1
    Secondary Accessions:
    • Q5RL41
    • Q6IN53
    • Q7Z357
    • Q8N2T3

    Protein attributes for NKAPD1 Gene

    Size:
    292 amino acids
    Molecular mass:
    34110 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NKAPD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKAPD1 Gene

Post-translational modifications for NKAPD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NKAPD1 Gene

Domains & Families for NKAPD1 Gene

Gene Families for NKAPD1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NKAPD1 Gene

InterPro:
genes like me logo Genes that share domains with NKAPD1: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for NKAPD1 Gene

Function for NKAPD1 Gene

Phenotypes From GWAS Catalog for NKAPD1 Gene

Gene Ontology (GO) - Molecular Function for NKAPD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IPI 32296183
genes like me logo Genes that share ontologies with NKAPD1: view
genes like me logo Genes that share phenotypes with NKAPD1: view

miRNA for NKAPD1 Gene

miRTarBase miRNAs that target NKAPD1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPD1

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAPD1 Gene

Localization for NKAPD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAPD1 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for NKAPD1 Gene

Pathways & Interactions for NKAPD1 Gene

PathCards logo

SuperPathways for NKAPD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKAPD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NKAPD1 Gene

Drugs & Compounds for NKAPD1 Gene

No Compound Related Data Available

Transcripts for NKAPD1 Gene

mRNA/cDNA for NKAPD1 Gene

6 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NKAPD1

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for NKAPD1 Gene

No ASD Table

Relevant External Links for NKAPD1 Gene

GeneLoc Exon Structure for
NKAPD1

Expression for NKAPD1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NKAPD1

Evidence on tissue expression from TISSUES for NKAPD1 Gene

  • Nervous system(4.7)
  • Intestine(4.3)
No Expression Related Data Available

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAPD1 Gene

Orthologs for NKAPD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NKAPD1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C11H11orf57 29
  • 99.54 (n)
C11orf57 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C15H11orf57 29
  • 93.41 (n)
MGC143285 30
  • 93 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C5H11orf57 29
  • 92.61 (n)
C11orf57 30
  • 92 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC100151767 29
  • 86.03 (n)
Mouse
(Mus musculus)
Mammalia AU019823 29 30
  • 85.16 (n)
OneToOne
Nkapd1 16
Oppossum
(Monodelphis domestica)
Mammalia C11orf57 30
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C11orf57 30
  • 57 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C24H11ORF57 29
  • 67.13 (n)
C11orf57 30
  • 50 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C11orf57 30
  • 50 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c11orf57 29
  • 54.69 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1381 29
Zebrafish
(Danio rerio)
Actinopterygii C15H11orf57 30
  • 42 (a)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5815 29
Species where no ortholog for NKAPD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NKAPD1 Gene

ENSEMBL:
Gene Tree for NKAPD1 (if available)
TreeFam:
Gene Tree for NKAPD1 (if available)
Alliance of Genome Resources:
Additional Orthologs for NKAPD1

Paralogs for NKAPD1 Gene

No data available for Paralogs for NKAPD1 Gene

Variants for NKAPD1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NKAPD1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NKAPD1 Gene

Variant ID Type Subtype PubMed ID
esv2745077 CNV deletion 23290073

Variation tolerance for NKAPD1 Gene

Residual Variation Intolerance Score: 24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKAPD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKAPD1
Leiden Open Variation Database (LOVD)
NKAPD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NKAPD1 Gene

Disorders for NKAPD1 Gene

Additional Disease Information for NKAPD1

No disorders were found for NKAPD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NKAPD1 Gene

Publications for NKAPD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3

Products for NKAPD1 Gene

Sources for NKAPD1 Gene