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Aliases for NKAIN2 Gene

Aliases for NKAIN2 Gene

  • Sodium/Potassium Transporting ATPase Interacting 2 2 3 5
  • Na(+)/K(+)-Transporting ATPase Subunit Beta-1-Interacting Protein 2 3 4
  • T-Cell Lymphoma Breakpoint-Associated Target Protein 1 3 4
  • Na+/K+ Transporting ATPase Interacting 2 2 3
  • FAM77B 3 4
  • TCBA1 3 4
  • Sodium/Potassium-Transporting ATPase Subunit Beta-1-Interacting Protein 2 3
  • T-Cell Lymphoma Breakpoint Associated Target 1 2
  • Protein FAM77B 4
  • NKAIP2 3
  • TCBA 3

External Ids for NKAIN2 Gene

Previous HGNC Symbols for NKAIN2 Gene

  • TCBA1

Previous GeneCards Identifiers for NKAIN2 Gene

  • GC06P124167
  • GC06P124125
  • GC06P121704

Summaries for NKAIN2 Gene

Entrez Gene Summary for NKAIN2 Gene

  • This gene encodes a transmembrane protein that interacts with the beta subunit of a sodium/potassium-transporting ATPase. A chromosomal translocation involving this gene is a cause of lymphoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for NKAIN2 Gene

NKAIN2 (Sodium/Potassium Transporting ATPase Interacting 2) is a Protein Coding gene. Diseases associated with NKAIN2 include Lymphoma. An important paralog of this gene is NKAIN1.

Additional gene information for NKAIN2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKAIN2 Gene

Genomics for NKAIN2 Gene

GeneHancer (GH) Regulatory Elements for NKAIN2 Gene

Promoters and enhancers for NKAIN2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I123802 Promoter/Enhancer 1.4 Ensembl ENCODE 550.8 -1.2 -1152 1.1 ZNF133 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 ZNF213 ZNF143 REST NKAIN2 TRDN
GH06I123803 Promoter/Enhancer 1.3 Ensembl ENCODE 550.8 -0.1 -138 0.6 ZNF133 KLF17 ZNF2 ZNF335 GLIS2 ZNF213 REST ZEB2 ZFP69B ZNF610 NKAIN2 TRDN
GH06I123804 Promoter/Enhancer 1.2 EPDnew ENCODE 550.8 +1.4 1350 2.3 MXI1 MZF1 FEZF1 ZNF2 ZNF335 POLR2A ZNF366 ZBTB48 PATZ1 SCRT2 NKAIN2 ENSG00000237321
GH06I123828 Enhancer 0.7 ENCODE 12.9 +25.9 25912 2.4 MZF1 FEZF1 HIC1 SCRT2 PRDM10 KLF7 TCF7L2 ZBTB20 SCRT1 ZNF843 NKAIN2 ENSG00000237321 GC06M124359
GH06I123876 Enhancer 0.2 FANTOM5 19.7 +73.0 73021 0.4 NKAIN2 ENSG00000237321 GC06M124359
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NKAIN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKAIN2 gene promoter:

Genomic Locations for NKAIN2 Gene

Genomic Locations for NKAIN2 Gene
1,021,821 bases
Plus strand

Genomic View for NKAIN2 Gene

Genes around NKAIN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKAIN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKAIN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKAIN2 Gene

Proteins for NKAIN2 Gene

  • Protein details for NKAIN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8IYR4
    • Q8TF67

    Protein attributes for NKAIN2 Gene

    208 amino acids
    Molecular mass:
    23831 Da
    Quaternary structure:
    • Interacts with ATP1B1.

    Alternative splice isoforms for NKAIN2 Gene


neXtProt entry for NKAIN2 Gene

Post-translational modifications for NKAIN2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for NKAIN2 Gene

Domains & Families for NKAIN2 Gene

Gene Families for NKAIN2 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Protein Domains for NKAIN2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NKAIN family.
  • Belongs to the NKAIN family.
genes like me logo Genes that share domains with NKAIN2: view

Function for NKAIN2 Gene

Phenotypes From GWAS Catalog for NKAIN2 Gene

genes like me logo Genes that share phenotypes with NKAIN2: view

Animal Model Products

CRISPR Products

miRNA for NKAIN2 Gene

miRTarBase miRNAs that target NKAIN2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NKAIN2 Gene

Localization for NKAIN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKAIN2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKAIN2 gene
Compartment Confidence
plasma membrane 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NKAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NKAIN2: view

Pathways & Interactions for NKAIN2 Gene

SuperPathways for NKAIN2 Gene

No Data Available

Interacting Proteins for NKAIN2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357402 for NKAIN2 Gene via STRING

Gene Ontology (GO) - Biological Process for NKAIN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002028 regulation of sodium ion transport IBA --
genes like me logo Genes that share ontologies with NKAIN2: view

No data available for Pathways by source and SIGNOR curated interactions for NKAIN2 Gene

Drugs & Compounds for NKAIN2 Gene

No Compound Related Data Available

Transcripts for NKAIN2 Gene

Unigene Clusters for NKAIN2 Gene

Na+/K+ transporting ATPase interacting 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKAIN2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: -
SP2: - -
SP3: -

Relevant External Links for NKAIN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NKAIN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKAIN2 Gene

mRNA differential expression in normal tissues according to GTEx for NKAIN2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x13.1), Brain - Substantia nigra (x5.8), Brain - Hippocampus (x5.3), Brain - Amygdala (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.3).

Protein differential expression in normal tissues from HIPED for NKAIN2 Gene

This gene is overexpressed in Spinal cord (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NKAIN2 Gene

Protein tissue co-expression partners for NKAIN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NKAIN2 Gene:


SOURCE GeneReport for Unigene cluster for NKAIN2 Gene:


mRNA Expression by UniProt/SwissProt for NKAIN2 Gene:

Tissue specificity: Expressed in fetal brain. Weakly expressed in adult brain and thymus. Not expressed in any other normal tissue examined.

Evidence on tissue expression from TISSUES for NKAIN2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with NKAIN2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for NKAIN2 Gene

Orthologs for NKAIN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for NKAIN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia -- 34
  • 100 (a)
-- 34
  • 93 (a)
(Pan troglodytes)
Mammalia NKAIN2 33 34
  • 99.84 (n)
(Monodelphis domestica)
Mammalia NKAIN2 34
  • 99 (a)
(Canis familiaris)
Mammalia NKAIN2 33 34
  • 97.75 (n)
(Mus musculus)
Mammalia Nkain2 33 16 34
  • 94.55 (n)
(Rattus norvegicus)
Mammalia LOC102551716 33
  • 94.53 (n)
(Ornithorhynchus anatinus)
Mammalia NKAIN2 34
  • 56 (a)
(Gallus gallus)
Aves NKAIN2 33 34
  • 86.54 (n)
(Anolis carolinensis)
Reptilia NKAIN2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nkain2 33
  • 80.93 (n)
(Danio rerio)
Actinopterygii nkain2 34
  • 87 (a)
LOC101883714 33
  • 73.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta NKAIN 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3479 34
  • 35 (a)
Species where no ortholog for NKAIN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKAIN2 Gene

Gene Tree for NKAIN2 (if available)
Gene Tree for NKAIN2 (if available)

Paralogs for NKAIN2 Gene

Paralogs for NKAIN2 Gene

(4) SIMAP similar genes for NKAIN2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with NKAIN2: view

Variants for NKAIN2 Gene

Sequence variations from dbSNP and Humsavar for NKAIN2 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000008638 -- 124,068,382(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000009277 -- 124,204,082(+) G/A intron_variant
rs1000010214 -- 124,279,277(+) G/A intron_variant
rs1000010260 -- 124,632,101(+) A/G intron_variant
rs1000010713 -- 123,989,013(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NKAIN2 Gene

Variant ID Type Subtype PubMed ID
nsv956535 CNV deletion 24416366
nsv955903 CNV deletion 24416366
nsv830794 CNV gain 17160897
nsv823835 CNV loss 20364138
nsv818454 CNV gain 17921354
nsv818453 CNV gain 17921354
nsv604598 CNV loss 21841781
nsv604597 CNV loss 21841781
nsv604596 CNV gain 21841781
nsv604595 CNV loss 21841781
nsv604594 CNV loss 21841781
nsv5464 CNV deletion 18451855
nsv5463 CNV deletion 18451855
nsv5462 CNV insertion 18451855
nsv525167 CNV loss 19592680
nsv524559 CNV gain 19592680
nsv517303 CNV gain 19592680
nsv514386 CNV gain 21397061
nsv512893 CNV insertion 21212237
nsv477592 CNV novel sequence insertion 20440878
nsv477297 CNV novel sequence insertion 20440878
nsv473019 CNV novel sequence insertion 20440878
nsv470859 CNV gain 18288195
nsv470858 CNV gain 18288195
nsv470857 CNV gain 18288195
nsv464057 CNV gain 19166990
nsv464055 CNV loss 19166990
nsv464054 CNV gain 19166990
nsv464042 CNV gain 19166990
nsv442007 CNV gain 18776908
nsv349664 CNV deletion 16902084
nsv348725 CNV deletion 16902084
nsv348535 CNV deletion 16902084
nsv1161449 CNV duplication 26073780
nsv1146605 CNV duplication 26484159
nsv1145738 CNV insertion 26484159
nsv1143160 CNV tandem duplication 24896259
nsv1142471 CNV tandem duplication 24896259
nsv1140691 CNV deletion 24896259
nsv1139871 CNV duplication 24896259
nsv1137557 CNV deletion 24896259
nsv1137145 CNV deletion 24896259
nsv1137144 CNV deletion 24896259
nsv1132010 CNV deletion 24896259
nsv1124943 CNV duplication 24896259
nsv1074958 CNV deletion 25765185
nsv1074426 CNV deletion 25765185
nsv1074012 CNV deletion 25765185
nsv1030013 CNV gain 25217958
nsv1027471 CNV loss 25217958
nsv1023991 CNV loss 25217958
nsv1018599 CNV gain 25217958
nsv1015660 CNV loss 25217958
esv998361 CNV gain 20482838
esv5558 CNV loss 19470904
esv4901 CNV loss 18987735
esv3890942 CNV loss 25118596
esv3890941 CNV loss 25118596
esv3890940 CNV loss 25118596
esv3756 CNV loss 18987735
esv3610672 CNV loss 21293372
esv3610670 CNV loss 21293372
esv3610665 CNV loss 21293372
esv3610660 CNV loss 21293372
esv3610658 CNV gain 21293372
esv3610656 CNV loss 21293372
esv3610655 CNV gain 21293372
esv3610652 CNV loss 21293372
esv3610647 CNV loss 21293372
esv3610646 CNV loss 21293372
esv3610644 CNV loss 21293372
esv3610643 CNV loss 21293372
esv3610642 CNV loss 21293372
esv3610641 CNV loss 21293372
esv3610640 CNV loss 21293372
esv3610639 CNV loss 21293372
esv3576223 CNV gain 25503493
esv3571384 CNV loss 25503493
esv3571383 CNV loss 25503493
esv3540425 CNV deletion 23714750
esv3540421 CNV deletion 23714750
esv3540420 CNV deletion 23714750
esv3540418 CNV deletion 23714750
esv3540417 CNV deletion 23714750
esv3438513 CNV insertion 20981092
esv3423931 CNV insertion 20981092
esv34079 CNV loss 18971310
esv3398522 CNV insertion 20981092
esv3341372 CNV insertion 20981092
esv3309661 CNV mobile element insertion 20981092
esv3307640 CNV mobile element insertion 20981092
esv3305844 CNV mobile element insertion 20981092
esv3305419 CNV mobile element insertion 20981092
esv3304191 CNV mobile element insertion 20981092
esv3302768 CNV tandem duplication 20981092
esv3091209 CNV deletion 24192839
esv3091162 CNV deletion 24192839
esv29157 CNV gain 19812545
esv2860346 CNV duplication 24192839
esv2843 CNV loss 18987735
esv2763597 CNV loss 21179565
esv2752089 CNV loss 17911159
esv2732674 CNV deletion 23290073
esv2732673 CNV deletion 23290073
esv2732671 CNV deletion 23290073
esv2732670 CNV deletion 23290073
esv2732669 CNV deletion 23290073
esv2732668 CNV deletion 23290073
esv2732667 CNV deletion 23290073
esv2732666 CNV deletion 23290073
esv2732665 CNV deletion 23290073
esv2732664 CNV deletion 23290073
esv2732663 CNV deletion 23290073
esv2732662 CNV deletion 23290073
esv2678659 CNV deletion 23128226
esv2675725 CNV deletion 23128226
esv2671870 CNV deletion 23128226
esv2663068 CNV deletion 23128226
esv2616735 CNV deletion 19546169
esv2571117 CNV deletion 19546169
esv2565664 CNV deletion 19546169
esv2532592 CNV deletion 19546169
esv2422137 CNV duplication 20811451
esv2403297 CNV deletion 18987734
esv2299970 CNV deletion 18987734
esv2156126 CNV deletion 18987734
esv2132883 CNV deletion 18987734
esv1174920 CNV insertion 17803354
esv1164700 CNV insertion 17803354
esv1159785 CNV insertion 17803354
esv1062584 CNV insertion 17803354
esv1003542 CNV deletion 20482838
dgv783n27 CNV gain 19166990
dgv6145n100 CNV gain 25217958
dgv6144n100 CNV gain 25217958
dgv6143n100 CNV loss 25217958
dgv3381n106 CNV deletion 24896259
dgv1828e212 CNV gain 25503493
dgv146e203 CNV gain 21179565
dgv145e203 CNV loss 21179565
dgv1216e214 CNV gain 21293372
dgv10924n54 CNV gain 21841781
dgv10923n54 CNV gain 21841781
dgv10922n54 CNV gain 21841781
dgv10921n54 CNV loss 21841781
dgv10920n54 CNV gain 21841781

Variation tolerance for NKAIN2 Gene

Residual Variation Intolerance Score: 29.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKAIN2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKAIN2 Gene

Disorders for NKAIN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NKAIN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards


  • Note=A chromosomal aberration involving NKAIN2 is a cause of lymphoma. Deletion del(6)(q13q21) within NKAIN2 and involving SUSP1 generates the SUSP1-NKAIN2 product (PubMed:11979551). {ECO:0000269 PubMed:11979551}.

Additional Disease Information for NKAIN2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with NKAIN2: view

No data available for Genatlas for NKAIN2 Gene

Publications for NKAIN2 Gene

  1. Molecular cytogenetic analysis of the breakpoint region at 6q21-22 in T-cell lymphoma/leukemia cell lines. (PMID: 11979551) Tagawa H … Seto M (Genes, chromosomes & cancer 2002) 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. A genome-wide association study of neuroticism in a population-based sample. (PMID: 20634892) Calboli FC … Balding DJ (PloS one 2010) 3 44 58
  5. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. (PMID: 17606467) Gorokhova S … Heintz N (Human molecular genetics 2007) 2 3 58

Products for NKAIN2 Gene

Sources for NKAIN2 Gene

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