Aliases for NIT2 Gene
External Ids for NIT2 Gene
Previous GeneCards Identifiers for NIT2 Gene
GeneCards Summary for NIT2 Gene
NIT2 (Nitrilase Family Member 2) is a Protein Coding gene. Diseases associated with NIT2 include Alkaptonuria. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds and omega-amidase activity. An important paralog of this gene is NIT1.
UniProtKB/Swiss-Prot Summary for NIT2 Gene
Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha-ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle.