The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009] See more...

Aliases for NINJ1 Gene

Aliases for NINJ1 Gene

  • Ninjurin 1 2 3 5
  • Nerve Injury-Induced Protein-1 2 3
  • Ninjurin-1 3 4
  • NIN1 2 3
  • Nerve Injury-Induced Protein 1 4
  • NINJURIN 3
  • NINJ1 5

External Ids for NINJ1 Gene

Previous GeneCards Identifiers for NINJ1 Gene

  • GC09M086710
  • GC09M087611
  • GC09M089182
  • GC09M091225
  • GC09M092963
  • GC09M094923
  • GC09M095883
  • GC09M065560

Summaries for NINJ1 Gene

Entrez Gene Summary for NINJ1 Gene

  • The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons.[supplied by OMIM, Aug 2009]

GeneCards Summary for NINJ1 Gene

NINJ1 (Ninjurin 1) is a Protein Coding gene. Diseases associated with NINJ1 include Hereditary Sensory Neuropathy and Non-Functioning Pancreatic Endocrine Tumor. An important paralog of this gene is NINJ2.

UniProtKB/Swiss-Prot Summary for NINJ1 Gene

  • Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.

Gene Wiki entry for NINJ1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NINJ1 Gene

Genomics for NINJ1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NINJ1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J093125 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 654.9 +3.7 3654 10.3 HNRNPL CREB1 GATAD2A ATF7 ZNF629 NFKBIZ KDM1A RCOR2 POLR2A BACH1 NINJ1 CARD19 ENSG00000223446 SUSD3 IPPK PHF2 lnc-C9orf129-2
GH09J093136 Promoter/Enhancer 0.9 Ensembl dbSUPER 600.7 -1.8 -1797 0.2 SP1 FOXA2 FOXP1 FOXA1 ZFP91 TFAP4 NFIA FOXA3 NINJ1 RF00017-7717 WNK2
GH09J093090 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.8 +38.6 38635 9.5 SP1 HNRNPL GATAD2A PRDM10 IKZF1 KDM1A ZNF692 POLR2A BACH1 JUND CARD19 ENSG00000223446 LOC101927993 PHF2 LINC00475 NOL8 NINJ1 IARS1 ZNF484 SUSD3
GH09J093118 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 34.3 +13.9 13886 2.8 HNRNPL GATAD2A PRDM10 TFE3 NFKBIZ CTCF RCOR2 POLR2A BACH1 JUND NINJ1 CARD19 SUSD3 IPPK PHF2 MN298632 lnc-C9orf129-2
GH09J093115 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.6 +18.0 18004 1.5 GATAD2A TFE3 RBFOX2 RXRB IRF2 ZNF740 SP1 GABPA CEBPA SOX13 MN298632 NINJ1 CARD19 SUSD3 IPPK FGD3 PHF2 FAM120A lnc-C9orf129-2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NINJ1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NINJ1

Top Transcription factor binding sites by QIAGEN in the NINJ1 gene promoter:
  • AML1a
  • ATF6
  • Bach2
  • E47
  • FOXO4
  • GATA-3
  • NF-kappaB1
  • p53
  • Pax-5

Genomic Locations for NINJ1 Gene

Genomic Locations for NINJ1 Gene
chr9:93,121,496-93,134,304
(GRCh38/hg38)
Size:
12,809 bases
Orientation:
Minus strand
chr9:95,883,771-95,896,570
(GRCh37/hg19)
Size:
12,800 bases
Orientation:
Minus strand

Genomic View for NINJ1 Gene

Genes around NINJ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NINJ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NINJ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NINJ1 Gene

Proteins for NINJ1 Gene

  • Protein details for NINJ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92982-NINJ1_HUMAN
    Recommended name:
    Ninjurin-1
    Protein Accession:
    Q92982
    Secondary Accessions:
    • Q6GU89
    • Q8WUV5
    • Q9BT07

    Protein attributes for NINJ1 Gene

    Size:
    152 amino acids
    Molecular mass:
    16345 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NINJ1 Gene

Post-translational modifications for NINJ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NINJ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for NINJ1

No data available for DME Specific Peptides for NINJ1 Gene

Domains & Families for NINJ1 Gene

Gene Families for NINJ1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for NINJ1 Gene

InterPro:
Blocks:
  • Ninjurin
ProtoNet:

Suggested Antigen Peptide Sequences for NINJ1 Gene

GenScript: Design optimal peptide antigens:
  • Nerve injury-induced protein 1 (NINJ1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92982

UniProtKB/Swiss-Prot:

NINJ1_HUMAN :
  • Belongs to the ninjurin family.
Family:
  • Belongs to the ninjurin family.
genes like me logo Genes that share domains with NINJ1: view

Function for NINJ1 Gene

Molecular function for NINJ1 Gene

UniProtKB/Swiss-Prot Function:
Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Cell adhesion requires divalent cations.
UniProtKB/Swiss-Prot Induction:
By nerve injury both in dorsal root ganglion neurons and in Schwann cells.
GENATLAS Biochemistry:
mouse ninjurin homolog,nerve injury induced protein,cell surface molecule,promoting axonal growth

Phenotypes From GWAS Catalog for NINJ1 Gene

Gene Ontology (GO) - Molecular Function for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NINJ1: view
genes like me logo Genes that share phenotypes with NINJ1: view

Animal Models for NINJ1 Gene

MGI Knock Outs for NINJ1:
  • Ninj1 Ninj1<tm1b(KOMP)Wtsi>
  • Ninj1 Ninj1<tm1Gto>
  • Ninj1 Ninj1<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NINJ1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NINJ1 Gene

Localization for NINJ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NINJ1 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NINJ1 gene
Compartment Confidence
plasma membrane 3
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
peroxisome 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with NINJ1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for NINJ1 Gene

Pathways & Interactions for NINJ1 Gene

PathCards logo

SuperPathways for NINJ1 Gene

No Data Available

Interacting Proteins for NINJ1 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 19)
STRING Interaction Network
Selected Interacting proteins: Q92982-NINJ1_HUMAN ENSP00000364595 for NINJ1 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for NINJ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001954 positive regulation of cell-matrix adhesion IEA --
GO:0007155 cell adhesion TAS,IBA 21873635
GO:0007399 nervous system development TAS 9261151
GO:0042246 tissue regeneration IEA --
GO:1990384 hyaloid vascular plexus regression IEA --
genes like me logo Genes that share ontologies with NINJ1: view

No data available for Pathways by source and SIGNOR curated interactions for NINJ1 Gene

Drugs & Compounds for NINJ1 Gene

No Compound Related Data Available

Transcripts for NINJ1 Gene

mRNA/cDNA for NINJ1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NINJ1

Alternative Splicing Database (ASD) splice patterns (SP) for NINJ1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c
SP1: - -
SP2: - - -
SP3: - - - -
SP4:
SP5: -

Relevant External Links for NINJ1 Gene

GeneLoc Exon Structure for
NINJ1

Expression for NINJ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NINJ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NINJ1 Gene

This gene is overexpressed in Whole Blood (x11.6).

Protein differential expression in normal tissues from HIPED for NINJ1 Gene

This gene is overexpressed in Frontal cortex (8.3), Spinal cord (6.8), Testis (6.6), Monocytes (6.5), and Ovary (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NINJ1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NINJ1

SOURCE GeneReport for Unigene cluster for NINJ1 Gene:

Hs.494457

mRNA Expression by UniProt/SwissProt for NINJ1 Gene:

Q92982-NINJ1_HUMAN
Tissue specificity: Widely expressed in both adult and embryonic tissues, primarily those of epithelial origin.

Evidence on tissue expression from TISSUES for NINJ1 Gene

  • Skin(4.5)
  • Lung(4.5)
  • Nervous system(2.7)
  • Bone marrow(2.6)
  • Heart(2.5)
  • Liver(2.4)
  • Spleen(2.2)
  • Intestine(2.2)
  • Blood(2.2)
  • Muscle(2.1)
  • Lymph node(2.1)
  • Adrenal gland(2.1)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with NINJ1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NINJ1 Gene

Orthologs for NINJ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NINJ1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia NINJ1 30 31
  • 99.56 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia NINJ1 30 31
  • 88.74 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ninj1 30 17 31
  • 87.06 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ninj1 30
  • 87.06 (n)
Cow
(Bos Taurus)
Mammalia NINJ1 30 31
  • 86.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia NINJ1 31
  • 78 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia NINJ1 31
  • 68 (a)
OneToOne
Chicken
(Gallus gallus)
Aves NINJ1 30 31
  • 68.53 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia NINJ1 31
  • 72 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ninj1 30
  • 68.6 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC100150223 30
  • 67.15 (n)
NINJ1 31
  • 60 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG14394 31
  • 34 (a)
ManyToMany
CG11637 31
  • 21 (a)
ManyToMany
NijA 31
  • 19 (a)
ManyToMany
Species where no ortholog for NINJ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NINJ1 Gene

ENSEMBL:
Gene Tree for NINJ1 (if available)
TreeFam:
Gene Tree for NINJ1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NINJ1: view image

Paralogs for NINJ1 Gene

Paralogs for NINJ1 Gene

(1) SIMAP similar genes for NINJ1 Gene using alignment to 1 proteins:

  • NINJ1_HUMAN
genes like me logo Genes that share paralogs with NINJ1: view

Variants for NINJ1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NINJ1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs2275848 - p.Ala110Asp

Additional dbSNP identifiers (rs#s) for NINJ1 Gene

Structural Variations from Database of Genomic Variants (DGV) for NINJ1 Gene

Variant ID Type Subtype PubMed ID
nsv1128505 CNV deletion 24896259
nsv1134927 CNV tandem duplication 24896259
nsv1161884 CNV deletion 26073780
nsv526296 CNV loss 19592680
nsv614879 CNV loss 21841781
nsv824982 CNV gain 20364138

Variation tolerance for NINJ1 Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NINJ1 Gene

Human Gene Mutation Database (HGMD)
NINJ1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
NINJ1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NINJ1 Gene

Disorders for NINJ1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NINJ1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hereditary sensory neuropathy
  • familial dysautonomia, type ii
non-functioning pancreatic endocrine tumor
  • non functioning pancreatic endocrine tumor
- elite association - COSMIC cancer census association via MalaCards
Search NINJ1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NINJ1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with NINJ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NINJ1 Gene

Publications for NINJ1 Gene

  1. Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth. (PMID: 8780658) Araki T … Milbrandt J (Neuron 1996) 2 3 4 23
  2. The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). (PMID: 9465296) Chadwick BP … Frischauf AM (Genomics 1998) 3 4 23
  3. Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule. (PMID: 9261151) Araki T … Milbrandt J (The Journal of biological chemistry 1997) 3 4 23
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41

Products for NINJ1 Gene

  • Signalway ELISA kits for NINJ1

Sources for NINJ1 Gene