Aliases for NIM1K Gene

Aliases for NIM1K Gene

  • NIM1 Serine/Threonine Protein Kinase 2 3 5
  • Serine/Threonine-Protein Kinase NIM1 3 4
  • EC 2.7.11.1 4 52
  • NIM1 3 4
  • NIM1 Serine/Threonine-Protein Kinase 4
  • EC 2.7.11 52

External Ids for NIM1K Gene

Previous GeneCards Identifiers for NIM1K Gene

  • GC05P043194
  • GC05P043201
  • GC05P043214
  • GC05P043229
  • GC05P043195

Summaries for NIM1K Gene

GeneCards Summary for NIM1K Gene

NIM1K (NIM1 Serine/Threonine Protein Kinase) is a Protein Coding gene. Diseases associated with NIM1K include Retinitis Pigmentosa 6. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is SIK2.

Additional gene information for NIM1K Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NIM1K Gene

Genomics for NIM1K Gene

GeneHancer (GH) Regulatory Elements for NIM1K Gene

Promoters and enhancers for NIM1K Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NIM1K on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NIM1K

Genomic Locations for NIM1K Gene

Genomic Locations for NIM1K Gene
chr5:43,192,054-43,280,850
(GRCh38/hg38)
Size:
88,797 bases
Orientation:
Plus strand
chr5:43,192,173-43,280,952
(GRCh37/hg19)
Size:
88,780 bases
Orientation:
Plus strand

Genomic View for NIM1K Gene

Genes around NIM1K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIM1K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIM1K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIM1K Gene

Proteins for NIM1K Gene

  • Protein details for NIM1K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY84-NIM1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase NIM1
    Protein Accession:
    Q8IY84
    Secondary Accessions:
    • B3KVM1

    Protein attributes for NIM1K Gene

    Size:
    436 amino acids
    Molecular mass:
    49606 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NIM1K Gene

Selected DME Specific Peptides for NIM1K Gene

Q8IY84:
  • IIHRDLKA
  • GSPPYAAPE

Post-translational modifications for NIM1K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIM1K Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for NIM1K Gene

Gene Families for NIM1K Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for NIM1K Gene

Suggested Antigen Peptide Sequences for NIM1K Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein kinase NIM1 (NIM1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IY84

UniProtKB/Swiss-Prot:

NIM1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NIM1K: view

Function for NIM1K Gene

Molecular function for NIM1K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; Evidence=. ;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Thr-229, probably by autophosphorylation.

Enzyme Numbers (IUBMB) for NIM1K Gene

Phenotypes From GWAS Catalog for NIM1K Gene

Gene Ontology (GO) - Molecular Function for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15733851
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA,IDA 15733851
GO:0005524 ATP binding IDA 15733851
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NIM1K: view
genes like me logo Genes that share phenotypes with NIM1K: view

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NIM1K

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NIM1K Gene

Localization for NIM1K Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIM1K gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with NIM1K: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NIM1K Gene

Pathways & Interactions for NIM1K Gene

PathCards logo

SuperPathways for NIM1K Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15733851
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA 21873635
genes like me logo Genes that share ontologies with NIM1K: view

No data available for Pathways by source and SIGNOR curated interactions for NIM1K Gene

Drugs & Compounds for NIM1K Gene

(2) Drugs for NIM1K Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
genes like me logo Genes that share compounds with NIM1K: view

Transcripts for NIM1K Gene

mRNA/cDNA for NIM1K Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NIM1K

Alternative Splicing Database (ASD) splice patterns (SP) for NIM1K Gene

No ASD Table

Relevant External Links for NIM1K Gene

GeneLoc Exon Structure for
NIM1K

Expression for NIM1K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for NIM1K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NIM1K Gene

This gene is overexpressed in Brain - Cortex (x4.7), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for NIM1K Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (51.4) and Skin (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for NIM1K Gene



Protein tissue co-expression partners for NIM1K Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NIM1K

Evidence on tissue expression from TISSUES for NIM1K Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NIM1K: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NIM1K Gene

Orthologs for NIM1K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NIM1K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIM1K 31
  • 100 (a)
OneToOne
LOC471558 30
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia NIM1K 31
  • 94 (a)
OneToOne
NIM1 30
  • 89.22 (n)
dog
(Canis familiaris)
Mammalia NIM1K 31
  • 94 (a)
OneToOne
NIM1 30
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Nim1 31
  • 92 (a)
OneToOne
Nim1k 17 30
  • 87.23 (n)
rat
(Rattus norvegicus)
Mammalia Nim1 30
  • 87.39 (n)
oppossum
(Monodelphis domestica)
Mammalia NIM1K 31
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIM1K 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIM1 31 30
  • 73.09 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NIM1K 31
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491267 30
  • 73.62 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536336 30
  • 68.15 (n)
NIM1K (1 of 3) 31
  • 68 (a)
OneToMany
NIM1K (3 of 3) 31
  • 55 (a)
OneToMany
NIM1K (2 of 3) 31
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4629 31
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F49C5.4 31 30
  • 53.8 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIN4 31
  • 10 (a)
ManyToMany
KCC4 31
  • 10 (a)
ManyToMany
HSL1 31
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 46 (a)
OneToOne
Species where no ortholog for NIM1K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIM1K Gene

ENSEMBL:
Gene Tree for NIM1K (if available)
TreeFam:
Gene Tree for NIM1K (if available)
Aminode:
Evolutionary constrained regions (ECRs) for NIM1K: view image

Paralogs for NIM1K Gene

(22) SIMAP similar genes for NIM1K Gene using alignment to 1 proteins:

  • NIM1_HUMAN
genes like me logo Genes that share paralogs with NIM1K: view

Variants for NIM1K Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NIM1K Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs866026698 A lung neuroendocrine carcinoma sample p.Pro333Ser
VAR_040950 A lung large cell carcinoma sample p.Pro411Thr
rs35659008 - p.Leu260Ile
rs55663207 - p.Glu64Gln
rs55664335 - p.Arg21Trp

Additional dbSNP identifiers (rs#s) for NIM1K Gene

Structural Variations from Database of Genomic Variants (DGV) for NIM1K Gene

Variant ID Type Subtype PubMed ID
esv2663072 CNV deletion 23128226
esv2676471 CNV deletion 23128226
esv2730137 CNV deletion 23290073
esv33224 CNV loss 17666407
esv3604892 CNV loss 21293372
esv3604893 CNV loss 21293372
esv3604894 CNV loss 21293372
esv3604895 CNV loss 21293372
nsv1140538 CNV deletion 24896259
nsv462126 CNV gain 19166990
nsv508352 CNV deletion 20534489
nsv597925 CNV gain 21841781
nsv830274 CNV loss 17160897
nsv968170 CNV duplication 23825009
nsv980639 CNV duplication 23825009

Variation tolerance for NIM1K Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NIM1K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NIM1K

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIM1K Gene

Disorders for NIM1K Gene

MalaCards: The human disease database

(1) MalaCards diseases for NIM1K Gene - From: DISEASES

Disorder Aliases PubMed IDs
retinitis pigmentosa 6
  • rp6
- elite association - COSMIC cancer census association via MalaCards
Search NIM1K in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NIM1K

genes like me logo Genes that share disorders with NIM1K: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NIM1K Gene

Publications for NIM1K Gene

  1. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PMID: 15733851) Jaleel M … Alessi DR (FEBS letters 2005) 2 3 4 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations. (PMID: 29568061) Liu X … Varjosalo M (Nature communications 2018) 3 54
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54

Products for NIM1K Gene

Sources for NIM1K Gene