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Aliases for NIM1K Gene

Aliases for NIM1K Gene

  • NIM1 Serine/Threonine Protein Kinase 2 3 5
  • EC 2.7.11.1 4 56
  • NIM1 3 4
  • Serine/Threonine-Protein Kinase NIM1 3
  • NIM1 Serine/Threonine-Protein Kinase 4
  • EC 2.7.11 56

External Ids for NIM1K Gene

Summaries for NIM1K Gene

GeneCards Summary for NIM1K Gene

NIM1K (NIM1 Serine/Threonine Protein Kinase) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MARK1.

Additional gene information for NIM1K Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIM1K Gene

Genomics for NIM1K Gene

GeneHancer (GH) Regulatory Elements for NIM1K Gene

Promoters and enhancers for NIM1K Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I043191 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.1 1075 2.8 CLOCK ARID4B ZNF2 ZBTB7B FOS KLF13 SP3 NFYC REST RFX3 NIM1K ZNF131 TMEM267 EEF1A1P19 ENSG00000249492 RPL29P12 C5orf34 LOC153684 AMD1P3 PAIP1
GH05I043231 Promoter 0.6 EPDnew 560.6 +39.8 39793 0.1 CTCF NIM1K GC05P043232 LOC100419036 HMGCS1 ENSG00000249888
GH05I043215 Enhancer 1 Ensembl ENCODE 13.1 +23.1 23147 0.4 HDAC1 PKNOX1 ATF1 FEZF1 CHAMP1 ZNF121 GATA2 ATF7 CEBPB ZEB2 NIM1K LOC100419037 ENSG00000249888
GH05I043033 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.6 -153.6 -153581 10.3 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZFP41 ZNF610 ZNF585B GLIS1 NBN ANXA2R ZNF131 ENSG00000249492 TMEM267 EEF1A1P19 AMD1P3 RPL29P12 LOC153684 ENSG00000272382 PAIP1
GH05I043074 Enhancer 1.2 ENCODE dbSUPER 10 -117.7 -117740 0.2 HDGF PKNOX1 ARNT ZNF2 ZNF121 POLR2B E2F8 ARID2 ZNF143 KLF7 PIR47359 PIR56928 PIR46975 ZNF131 ANXA2R TMEM267 RPL29P12 LOC153684 ENSG00000272382 ENSG00000249492
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NIM1K on UCSC Golden Path with GeneCards custom track

Genomic Locations for NIM1K Gene

Genomic Locations for NIM1K Gene
chr5:43,192,054-43,280,850
(GRCh38/hg38)
Size:
88,797 bases
Orientation:
Plus strand
chr5:43,192,173-43,280,952
(GRCh37/hg19)

Genomic View for NIM1K Gene

Genes around NIM1K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIM1K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIM1K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIM1K Gene

Proteins for NIM1K Gene

  • Protein details for NIM1K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY84-NIM1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase NIM1
    Protein Accession:
    Q8IY84
    Secondary Accessions:
    • B3KVM1

    Protein attributes for NIM1K Gene

    Size:
    436 amino acids
    Molecular mass:
    49606 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for NIM1K Gene

Selected DME Specific Peptides for NIM1K Gene

Q8IY84:
  • IIHRDLKA
  • GSPPYAAPE

Post-translational modifications for NIM1K Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NIM1K Gene

Domains & Families for NIM1K Gene

Gene Families for NIM1K Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for NIM1K Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY84

UniProtKB/Swiss-Prot:

NIM1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with NIM1K: view

Function for NIM1K Gene

Molecular function for NIM1K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation at Thr-229, probably by autophosphorylation.

Enzyme Numbers (IUBMB) for NIM1K Gene

Phenotypes From GWAS Catalog for NIM1K Gene

Gene Ontology (GO) - Molecular Function for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 15733851
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IDA,IEA 15733851
GO:0005524 ATP binding IDA 15733851
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with NIM1K: view
genes like me logo Genes that share phenotypes with NIM1K: view

Animal Model Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for NIM1K Gene

Localization for NIM1K Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIM1K gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with NIM1K: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NIM1K Gene

Pathways & Interactions for NIM1K Gene

SuperPathways for NIM1K Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIM1K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 15733851
GO:0016310 phosphorylation IEA --
GO:0035556 intracellular signal transduction IBA --
genes like me logo Genes that share ontologies with NIM1K: view

No data available for Pathways by source and SIGNOR curated interactions for NIM1K Gene

Drugs & Compounds for NIM1K Gene

(1) Drugs for NIM1K Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Approved Nutra 0
genes like me logo Genes that share compounds with NIM1K: view

Transcripts for NIM1K Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for NIM1K Gene

No ASD Table

Relevant External Links for NIM1K Gene

GeneLoc Exon Structure for
NIM1K
ECgene alternative splicing isoforms for
NIM1K

Expression for NIM1K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NIM1K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NIM1K Gene

This gene is overexpressed in Brain - Cortex (x4.7), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Nucleus accumbens (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for NIM1K Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (51.4) and Skin (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NIM1K Gene



Protein tissue co-expression partners for NIM1K Gene

NURSA nuclear receptor signaling pathways regulating expression of NIM1K Gene:

NIM1K

Evidence on tissue expression from TISSUES for NIM1K Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with NIM1K: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NIM1K Gene

Orthologs for NIM1K Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NIM1K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NIM1K 34
  • 100 (a)
OneToOne
LOC471558 33
  • 99.46 (n)
cow
(Bos Taurus)
Mammalia NIM1K 34
  • 94 (a)
OneToOne
NIM1 33
  • 89.22 (n)
dog
(Canis familiaris)
Mammalia NIM1K 34
  • 94 (a)
OneToOne
NIM1 33
  • 87.69 (n)
mouse
(Mus musculus)
Mammalia Nim1 34
  • 92 (a)
OneToOne
Nim1k 33 16
  • 87.23 (n)
rat
(Rattus norvegicus)
Mammalia Nim1 33
  • 87.39 (n)
oppossum
(Monodelphis domestica)
Mammalia NIM1K 34
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NIM1K 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves NIM1 33 34
  • 73.09 (n)
lizard
(Anolis carolinensis)
Reptilia NIM1K 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491267 33
  • 73.62 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536336 33
  • 68.15 (n)
NIM1K (1 of 3) 34
  • 68 (a)
OneToMany
NIM1K (2 of 3) 34
  • 55 (a)
OneToMany
NIM1K (3 of 3) 34
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4629 34
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F49C5.4 33 34
  • 53.8 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GIN4 34
  • 10 (a)
ManyToMany
KCC4 34
  • 10 (a)
ManyToMany
HSL1 34
  • 8 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 46 (a)
OneToOne
Species where no ortholog for NIM1K was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIM1K Gene

ENSEMBL:
Gene Tree for NIM1K (if available)
TreeFam:
Gene Tree for NIM1K (if available)

Paralogs for NIM1K Gene

Paralogs for NIM1K Gene

(22) SIMAP similar genes for NIM1K Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NIM1K: view

Variants for NIM1K Gene

Sequence variations from dbSNP and Humsavar for NIM1K Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs866026698 A lung neuroendocrine carcinoma sample 43,280,415(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
VAR_040950 A lung large cell carcinoma sample p.Pro411Thr
rs1000036100 -- 43,193,236(+) G/A genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000036411 -- 43,267,201(+) T/C intron_variant
rs1000092958 -- 43,255,673(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NIM1K Gene

Variant ID Type Subtype PubMed ID
esv2663072 CNV deletion 23128226
esv2676471 CNV deletion 23128226
esv2730137 CNV deletion 23290073
esv33224 CNV loss 17666407
esv3604892 CNV loss 21293372
esv3604893 CNV loss 21293372
esv3604894 CNV loss 21293372
esv3604895 CNV loss 21293372
nsv1140538 CNV deletion 24896259
nsv462126 CNV gain 19166990
nsv508352 CNV deletion 20534489
nsv597925 CNV gain 21841781
nsv830274 CNV loss 17160897
nsv968170 CNV duplication 23825009
nsv980639 CNV duplication 23825009

Variation tolerance for NIM1K Gene

Residual Variation Intolerance Score: 35.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NIM1K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NIM1K

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIM1K Gene

Disorders for NIM1K Gene

Additional Disease Information for NIM1K

No disorders were found for NIM1K Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIM1K Gene

Publications for NIM1K Gene

  1. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. (PMID: 15733851) Jaleel M … Alessi DR (FEBS letters 2005) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) Oláh J … Ovádi J (The Journal of biological chemistry 2011) 3 58
  5. Patterns of somatic mutation in human cancer genomes. (PMID: 17344846) Greenman C … Stratton MR (Nature 2007) 4 58

Products for NIM1K Gene

Sources for NIM1K Gene

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