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Aliases for NIFK Gene

Aliases for NIFK Gene

  • Nucleolar Protein Interacting With The FHA Domain Of MKI67 2 3 5
  • Nucleolar Protein Interacting With The FHA Domain Of PKi-67 2 3
  • Nucleolar Phosphoprotein Nopp34 3 4
  • MKI67IP 3 4
  • HNIFK 3 4
  • Nucleolar Protein Interacting With The FHA Domain Of PKI-67 4
  • MKI67 (FHA Domain) Interacting Nucleolar Phosphoprotein 2
  • MKI67 FHA Domain-Interacting Nucleolar Phosphoprotein 3
  • Nopp34 3
  • NOPP34 4

External Ids for NIFK Gene

Previous HGNC Symbols for NIFK Gene

  • MKI67IP

Previous GeneCards Identifiers for NIFK Gene

  • GC02M122485

Summaries for NIFK Gene

Entrez Gene Summary for NIFK Gene

  • This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

GeneCards Summary for NIFK Gene

NIFK (Nucleolar Protein Interacting With The FHA Domain Of MKI67) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding.

Gene Wiki entry for NIFK Gene

Additional gene information for NIFK Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NIFK Gene

Genomics for NIFK Gene

GeneHancer (GH) Regulatory Elements for NIFK Gene

Promoters and enhancers for NIFK Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J121735 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 -0.2 -179 3.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B E2F8 NIFK TSN LINC01823 ENSG00000270798
GH02J121524 Promoter/Enhancer 2 Ensembl ENCODE dbSUPER 10.6 +207.9 207888 9.2 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 RNU4ATAC GC02P121532 ENSG00000265451 NIFK TSN LINC01823 CLASP1 GC02M121346
GH02J121706 Enhancer 1 Ensembl ENCODE 11.8 +28.9 28943 2.5 ELF3 FOXA2 INSM2 ARID4B FEZF1 RARA SLC30A9 ZNF213 ZNF366 ZSCAN5C NPM1P32 TSN NIFK ENSG00000279721 NIFK-AS1
GH02J121476 Enhancer 0.9 Ensembl ENCODE dbSUPER 10.5 +260.3 260274 1.1 GATA3 FOXA2 SMAD5 PRDM10 TSN NIFK ENSG00000265451 GC02M121346 CLASP1
GH02J121399 Enhancer 0.3 ENCODE 10.8 +336.6 336647 0.9 FOS NIFK TSN LINC01823 GC02M121346 GC02M121365 CLASP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NIFK on UCSC Golden Path with GeneCards custom track

Genomic Locations for NIFK Gene

Genomic Locations for NIFK Gene
9,983 bases
Minus strand
9,983 bases
Minus strand

Genomic View for NIFK Gene

Genes around NIFK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIFK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIFK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIFK Gene

Proteins for NIFK Gene

  • Protein details for NIFK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MKI67 FHA domain-interacting nucleolar phosphoprotein
    Protein Accession:
    Secondary Accessions:
    • A8K788
    • Q8TB66
    • Q96ED4

    Protein attributes for NIFK Gene

    293 amino acids
    Molecular mass:
    34222 Da
    Quaternary structure:
    • Binds to the FHA domain of MKI67; this interaction is enhanced in mitosis.

    Three dimensional structures from OCA and Proteopedia for NIFK Gene

neXtProt entry for NIFK Gene

Post-translational modifications for NIFK Gene

  • Sequentially phosphorylated on Thr-238, Thr-234 and Ser-230. Thr-234 is phosphorylated only when Thr-238 is phosphorylated. Likewise, phosphorylation at Ser-230 requires that Thr-234 and Thr-238 are phosphorylated. Phosphorylation enhances MKI67 binding.
  • Ubiquitination at isoforms=139
  • Modification sites at PhosphoSitePlus

Other Protein References for NIFK Gene

No data available for DME Specific Peptides for NIFK Gene

Domains & Families for NIFK Gene

Gene Families for NIFK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NIFK Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NIFK: view

No data available for UniProtKB/Swiss-Prot for NIFK Gene

Function for NIFK Gene

Phenotypes From GWAS Catalog for NIFK Gene

Gene Ontology (GO) - Molecular Function for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,IDA 11342549
GO:0005515 protein binding IPI 11342549
genes like me logo Genes that share ontologies with NIFK: view
genes like me logo Genes that share phenotypes with NIFK: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NIFK

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIFK Gene

Localization for NIFK Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIFK Gene

Nucleus, nucleolus. Chromosome. Note=Localizes to mitotic chromosomes in conjunction with MKI67.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIFK gene
Compartment Confidence
nucleus 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IDA 11342549
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA 11342549
GO:0005694 chromosome IEA --
GO:0005730 nucleolus IDA 11342549
genes like me logo Genes that share ontologies with NIFK: view

Pathways & Interactions for NIFK Gene

No Data Available

Gene Ontology (GO) - Biological Process for NIFK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009303 rRNA transcription NAS 11342549
GO:0016072 rRNA metabolic process NAS 11342549
GO:0065003 protein-containing complex assembly NAS 11342549
genes like me logo Genes that share ontologies with NIFK: view

No data available for Pathways by source and SIGNOR curated interactions for NIFK Gene

Drugs & Compounds for NIFK Gene

No Compound Related Data Available

Transcripts for NIFK Gene

mRNA/cDNA for NIFK Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NIFK

Alternative Splicing Database (ASD) splice patterns (SP) for NIFK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP3: -

Relevant External Links for NIFK Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NIFK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NIFK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NIFK Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.3) and CD8 Tcells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for NIFK Gene

Protein tissue co-expression partners for NIFK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NIFK Gene:


Evidence on tissue expression from TISSUES for NIFK Gene

  • Nervous system(4.7)
  • Lung(4.2)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with NIFK: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NIFK Gene

Orthologs for NIFK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NIFK Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MKI67IP 34 33
  • 99.43 (n)
(Bos Taurus)
Mammalia NIFK 33
  • 82.82 (n)
MKI67IP 34
  • 73 (a)
(Canis familiaris)
Mammalia MKI67IP 33
  • 82.37 (n)
  • 69 (a)
(Rattus norvegicus)
Mammalia Nifk 33
  • 72.45 (n)
(Mus musculus)
Mammalia Nifk 16 33
  • 70.02 (n)
Mki67ip 34
  • 56 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 61 (a)
-- 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia NIFK 34
  • 48 (a)
(Gallus gallus)
Aves MKI67IP 33
  • 60.19 (n)
  • 51 (a)
(Anolis carolinensis)
Reptilia NIFK 34
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nifk 33
  • 57.98 (n)
Str.1406 33
African clawed frog
(Xenopus laevis)
Amphibia LOC398645 33
(Danio rerio)
Actinopterygii nifk 34 33
  • 60.66 (n)
mki67ipl 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11192 33
fruit fly
(Drosophila melanogaster)
Insecta CG6937 34
  • 22 (a)
(Caenorhabditis elegans)
Secernentea T04A8.6 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NOP15 36 34
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G04600 33
  • 48.15 (n)
(Oryza sativa)
Liliopsida Os08g0412200 33
  • 51.37 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10558 34
  • 29 (a)
Species where no ortholog for NIFK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NIFK Gene

Gene Tree for NIFK (if available)
Gene Tree for NIFK (if available)
Evolutionary constrained regions (ECRs) for NIFK: view image

Paralogs for NIFK Gene

No data available for Paralogs for NIFK Gene

Variants for NIFK Gene

Sequence variations from dbSNP and Humsavar for NIFK Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000500782 -- 121,727,465(-) T/C 3_prime_UTR_variant
rs1000526848 -- 121,737,477(-) C/A upstream_transcript_variant
rs1000813779 -- 121,737,760(-) C/G upstream_transcript_variant
rs1001079870 -- 121,726,529(-) /G downstream_transcript_variant
rs1001153569 -- 121,737,135(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NIFK Gene

Variant ID Type Subtype PubMed ID
esv3592209 CNV gain 21293372
esv3592217 CNV gain 21293372
nsv1011665 CNV gain 25217958
nsv459163 CNV gain 19166990
nsv582808 CNV gain 21841781
nsv834351 CNV loss 17160897
nsv961503 CNV duplication 23825009

Variation tolerance for NIFK Gene

Residual Variation Intolerance Score: 54.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 48.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NIFK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NIFK Gene

Disorders for NIFK Gene

Additional Disease Information for NIFK

No disorders were found for NIFK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NIFK Gene

Publications for NIFK Gene

  1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. (PMID: 11342549) Takagi M … Yoneda Y (The Journal of biological chemistry 2001) 2 3 4 22 58
  2. Sequential phosphorylation and multisite interactions characterize specific target recognition by the FHA domain of Ki67. (PMID: 16244663) Byeon IJ … Tsai MD (Nature structural & molecular biology 2005) 2 3 4 58
  3. Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions. (PMID: 14659764) Li H … Tsai MD (Journal of molecular biology 2004) 2 3 4 58
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for NIFK Gene

Sources for NIFK Gene

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