Aliases for NIBAN2 Gene

Aliases for NIBAN2 Gene

  • Niban Apoptosis Regulator 2 2 3 5
  • Melanoma Invasion By ERK 2 3 4
  • MINERVA 2 3 4
  • Family With Sequence Similarity 129 Member B 2 3
  • Niban-Like Protein 1 3 4
  • Protein Niban 2 3 4
  • BA356B19.6 2 3
  • C9orf88 3 4
  • FAM129B 3 4
  • Chromosome 9 Open Reading Frame 88 2
  • Protein FAM129B 4
  • DKFZP434H0820 2
  • FLJ13518 2
  • FLJ22151 2
  • FLJ22298 2
  • NIBAN2 5
  • MEG-3 3
  • Meg-3 4
  • OC58 3

External Ids for NIBAN2 Gene

Previous HGNC Symbols for NIBAN2 Gene

  • C9orf88
  • FAM129B

Previous GeneCards Identifiers for NIBAN2 Gene

  • GC09M127506
  • GC09M127509
  • GC09M127516

Summaries for NIBAN2 Gene

GeneCards Summary for NIBAN2 Gene

NIBAN2 (Niban Apoptosis Regulator 2) is a Protein Coding gene. Diseases associated with NIBAN2 include Melanoma. Among its related pathways are MAP Kinase Signaling. An important paralog of this gene is NIBAN1.

UniProtKB/Swiss-Prot Summary for NIBAN2 Gene

  • May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for NIBAN2 Gene

Genomics for NIBAN2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for NIBAN2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around NIBAN2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for NIBAN2

Genomic Locations for NIBAN2 Gene

Latest Assembly
73,693 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
73,689 bases
Minus strand

(GRCh37/hg19 by Ensembl)
73,651 bases
Minus strand

Genomic View for NIBAN2 Gene

Genes around NIBAN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NIBAN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NIBAN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NIBAN2 Gene

Proteins for NIBAN2 Gene

  • Protein details for NIBAN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Niban 2
    Protein Accession:
    Secondary Accessions:
    • Q4LE55
    • Q5VVW6
    • Q5VVW7
    • Q9BUS2
    • Q9NT35

    Protein attributes for NIBAN2 Gene

    746 amino acids
    Molecular mass:
    84138 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for NIBAN2 Gene


neXtProt entry for NIBAN2 Gene

Post-translational modifications for NIBAN2 Gene

  • Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.
  • As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.
  • Ubiquitination at Lys316, Lys401, and Lys430
  • Modification sites at PhosphoSitePlus

Other Protein References for NIBAN2 Gene

No data available for DME Specific Peptides for NIBAN2 Gene

Domains & Families for NIBAN2 Gene

Gene Families for NIBAN2 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for NIBAN2 Gene

  • Pleckstrin-like

Suggested Antigen Peptide Sequences for NIBAN2 Gene

GenScript: Design optimal peptide antigens:
  • Protein FAM129B (NIBL1_HUMAN)
  • FAM129B protein (Q2YD88_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Niban family.
  • Belongs to the Niban family.
genes like me logo Genes that share domains with NIBAN2: view

Function for NIBAN2 Gene

Molecular function for NIBAN2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.

Phenotypes From GWAS Catalog for NIBAN2 Gene

Gene Ontology (GO) - Molecular Function for NIBAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 17569660
GO:0005515 protein binding IPI 19615732
GO:0045296 cadherin binding HDA 25468996
genes like me logo Genes that share ontologies with NIBAN2: view
genes like me logo Genes that share phenotypes with NIBAN2: view

miRNA for NIBAN2 Gene

miRTarBase miRNAs that target NIBAN2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NIBAN2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NIBAN2 Gene

Localization for NIBAN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NIBAN2 Gene

Cytoplasm, cytosol. Cell junction, adherens junction. Membrane. Lipid-anchor. Note=In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NIBAN2 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
cytoskeleton 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Plasma membrane (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NIBAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 21148485
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 14602737
GO:0005829 cytosol IEA,IDA 21148485
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with NIBAN2: view

Pathways & Interactions for NIBAN2 Gene

PathCards logo

SuperPathways for NIBAN2 Gene

SuperPathway Contained pathways
1 MAP Kinase Signaling
genes like me logo Genes that share pathways with NIBAN2: view

Pathways by source for NIBAN2 Gene

1 Cell Signaling Technology pathway for NIBAN2 Gene

Gene Ontology (GO) - Biological Process for NIBAN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance ISS --
GO:0008285 negative regulation of cell proliferation IDA 14602737
GO:0016525 negative regulation of angiogenesis ISS --
GO:0030154 cell differentiation ISS --
GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with NIBAN2: view

No data available for SIGNOR curated interactions for NIBAN2 Gene

Drugs & Compounds for NIBAN2 Gene

No Compound Related Data Available

Transcripts for NIBAN2 Gene

mRNA/cDNA for NIBAN2 Gene

16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for NIBAN2

Alternative Splicing Database (ASD) splice patterns (SP) for NIBAN2 Gene

No ASD Table

Relevant External Links for NIBAN2 Gene

GeneLoc Exon Structure for

Expression for NIBAN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for NIBAN2

SOURCE GeneReport for Unigene cluster for NIBAN2 Gene:


Evidence on tissue expression from TISSUES for NIBAN2 Gene

  • Liver(4.2)
  • Lung(3.7)
  • Skin(3.4)
  • Nervous system(2.5)
  • Intestine(2)
genes like me logo Genes that share expression patterns with NIBAN2: view

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NIBAN2 Gene

Orthologs for NIBAN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NIBAN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FAM129B 29 30
  • 98.95 (n)
(Bos Taurus)
Mammalia FAM129B 29 30
  • 90.02 (n)
(Canis familiaris)
Mammalia FAM129B 29 30
  • 88.86 (n)
(Mus musculus)
Mammalia Fam129b 29 30
  • 86.85 (n)
Niban2 16
(Rattus norvegicus)
Mammalia Fam129b 29
  • 86.26 (n)
(Monodelphis domestica)
Mammalia FAM129B 30
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia FAM129B 30
  • 68 (a)
(Gallus gallus)
Aves FAM129B 29 30
  • 78.99 (n)
(Anolis carolinensis)
Reptilia FAM129B 30
  • 65 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fam129b 29
  • 69.2 (n)
Str.8124 29
(Danio rerio)
Actinopterygii fam129bb 29 30
  • 66.77 (n)
FAM129B (3 of 3) 30
  • 53 (a)
fam129ba 30
  • 48 (a)
Species where no ortholog for NIBAN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for NIBAN2 Gene

Gene Tree for NIBAN2 (if available)
Gene Tree for NIBAN2 (if available)
Evolutionary constrained regions (ECRs) for NIBAN2: view image
Alliance of Genome Resources:
Additional Orthologs for NIBAN2

Paralogs for NIBAN2 Gene

Paralogs for NIBAN2 Gene

genes like me logo Genes that share paralogs with NIBAN2: view

Variants for NIBAN2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for NIBAN2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for NIBAN2 Gene

Variant ID Type Subtype PubMed ID
esv2739053 CNV deletion 23290073
nsv1133741 CNV deletion 24896259
nsv1145265 CNV deletion 24896259
nsv466569 CNV loss 19166990
nsv466570 CNV loss 19166990
nsv615368 CNV loss 21841781

Variation tolerance for NIBAN2 Gene

Residual Variation Intolerance Score: 49.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NIBAN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for NIBAN2 Gene

Disorders for NIBAN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for NIBAN2 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for NIBAN2

genes like me logo Genes that share disorders with NIBAN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NIBAN2 Gene

Publications for NIBAN2 Gene

  1. Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. (PMID: 19362540) Old WM … Ahn NG (Molecular cell 2009) 2 3 4
  2. EGFR phosphorylates FAM129B to promote Ras activation. (PMID: 26721396) Ji H … Lu Z (Proceedings of the National Academy of Sciences of the United States of America 2016) 2 3
  3. FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells. (PMID: 21148485) Chen S … Evans DR (The Journal of biological chemistry 2011) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for NIBAN2 Gene

Sources for NIBAN2 Gene