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Aliases for NHSL1 Gene

Aliases for NHSL1 Gene

  • NHS Like 1 2 3 5
  • C6orf63 3 4
  • Chromosome 6 Open Reading Frame 63 2
  • NHS-Like Protein 1 3
  • KIAA1357 4

External Ids for NHSL1 Gene

Previous HGNC Symbols for NHSL1 Gene

  • C6orf63

Previous GeneCards Identifiers for NHSL1 Gene

  • GC06M138784
  • GC06M136304
  • GC06M138743

Summaries for NHSL1 Gene

GeneCards Summary for NHSL1 Gene

NHSL1 (NHS Like 1) is a Protein Coding gene. An important paralog of this gene is NHS.

Additional gene information for NHSL1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHSL1 Gene

Genomics for NHSL1 Gene

GeneHancer (GH) Regulatory Elements for NHSL1 Gene

Promoters and enhancers for NHSL1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I138569 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 557.4 +121.1 121148 3.5 FOXA2 ZFP64 ARID4B DMAP1 ZNF48 YY1 SLC30A9 RXRA SP5 NFYC NHSL1 PBOV1 LOC100129577 ENSG00000274594
GH06I138496 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 562.7 +189.5 189488 13.3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 NHSL1 PERP REPS1 ENSG00000274594 LOC100129577
GH06I138689 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 550.8 +0.8 788 4.5 PKNOX1 ARNT ARID4B SIN3A ZNF2 ZBTB7B ZNF48 SLC30A9 GLIS2 ZNF143 FLJ46906 NHSL1
GH06I138535 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 26.6 +150.9 150892 12.8 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF121 FOS NHSL1 FLJ46906 PERP HEBP2 PBOV1 ENSG00000274594 LOC100129577
GH06I138549 Enhancer 1.1 ENCODE dbSUPER 27.6 +142.4 142373 1.3 FOXA2 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 RXRA SP5 MXD4 NHSL1 FLJ46906 ENSG00000274594 LOC100129577
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NHSL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NHSL1 gene promoter:

Genomic Locations for NHSL1 Gene

Genomic Locations for NHSL1 Gene
270,574 bases
Minus strand

Genomic View for NHSL1 Gene

Genes around NHSL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHSL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHSL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHSL1 Gene

Proteins for NHSL1 Gene

  • Protein details for NHSL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHS-like protein 1
    Protein Accession:
    Secondary Accessions:
    • Q3ZCS5
    • Q5SYE8
    • Q9P2J0

    Protein attributes for NHSL1 Gene

    1610 amino acids
    Molecular mass:
    170668 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI12098.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI12099.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14156.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14157.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for NHSL1 Gene


neXtProt entry for NHSL1 Gene

Post-translational modifications for NHSL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NHSL1 Gene

Domains & Families for NHSL1 Gene

Gene Families for NHSL1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NHSL1 Gene


Suggested Antigen Peptide Sequences for NHSL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the NHS family.
  • Belongs to the NHS family.
genes like me logo Genes that share domains with NHSL1: view

Function for NHSL1 Gene

Phenotypes From GWAS Catalog for NHSL1 Gene

Phenotypes for NHSL1 Gene

genes like me logo Genes that share phenotypes with NHSL1: view

Animal Models for NHSL1 Gene

MGI Knock Outs for NHSL1:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NHSL1 Gene

Localization for NHSL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NHSL1 gene
Compartment Confidence
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NHSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with NHSL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NHSL1 Gene

Pathways & Interactions for NHSL1 Gene

SuperPathways for NHSL1 Gene

No Data Available

Interacting Proteins for NHSL1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000394546 Q5SYE7-NHSL1_HUMAN for NHSL1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for NHSL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097475 motor neuron migration IBA --
genes like me logo Genes that share ontologies with NHSL1: view

No data available for Pathways by source and SIGNOR curated interactions for NHSL1 Gene

Drugs & Compounds for NHSL1 Gene

No Compound Related Data Available

Transcripts for NHSL1 Gene

Unigene Clusters for NHSL1 Gene

NHS-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHSL1 Gene

No ASD Table

Relevant External Links for NHSL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHSL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NHSL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NHSL1 Gene

This gene is overexpressed in Plasma (47.0) and Placenta (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NHSL1 Gene

Protein tissue co-expression partners for NHSL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of NHSL1 Gene:


SOURCE GeneReport for Unigene cluster for NHSL1 Gene:


mRNA Expression by UniProt/SwissProt for NHSL1 Gene:

Tissue specificity: Widely expressed. Expressed in adult and fetal brain, fetal eyes, adult lens, kidney, liver and intestine.

Evidence on tissue expression from TISSUES for NHSL1 Gene

  • Liver(4.3)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with NHSL1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for NHSL1 Gene

Orthologs for NHSL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHSL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHSL1 33 34
  • 98.96 (n)
(Canis familiaris)
Mammalia NHSL1 33 34
  • 83.7 (n)
(Bos Taurus)
Mammalia NHSL1 33 34
  • 82.58 (n)
(Mus musculus)
Mammalia Nhsl1 33 16 34
  • 81.17 (n)
(Rattus norvegicus)
Mammalia Nhsl1 33
  • 80.42 (n)
(Monodelphis domestica)
Mammalia NHSL1 34
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
-- 34
  • 51 (a)
(Gallus gallus)
Aves NHSL1 34
  • 51 (a)
(Anolis carolinensis)
Reptilia NHSL1 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhsl1 33
  • 54.57 (n)
(Danio rerio)
Actinopterygii nhsl1b 33 34
  • 60.01 (n)
nhsl1a 34
  • 34 (a)
Species where no ortholog for NHSL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHSL1 Gene

Gene Tree for NHSL1 (if available)
Gene Tree for NHSL1 (if available)

Paralogs for NHSL1 Gene

Paralogs for NHSL1 Gene

genes like me logo Genes that share paralogs with NHSL1: view

Variants for NHSL1 Gene

Sequence variations from dbSNP and Humsavar for NHSL1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000002182 -- 138,587,354(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000004881 -- 138,627,860(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000016156 -- 138,533,836(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000022885 -- 138,548,339(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000034519 -- 138,539,497(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NHSL1 Gene

Variant ID Type Subtype PubMed ID
esv1934223 CNV deletion 18987734
esv2399126 CNV deletion 18987734
esv2469347 CNV deletion 19546169
esv2732769 CNV deletion 23290073
esv2732770 CNV deletion 23290073
esv2732771 CNV deletion 23290073
esv2752090 CNV gain 17911159
esv3610957 CNV loss 21293372
nsv1117668 CNV deletion 24896259
nsv1124122 CNV deletion 24896259
nsv5499 CNV deletion 18451855

Variation tolerance for NHSL1 Gene

Gene Damage Index Score: 4.65; 65.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NHSL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHSL1 Gene

Disorders for NHSL1 Gene

Additional Disease Information for NHSL1

No disorders were found for NHSL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHSL1 Gene

Publications for NHSL1 Gene

  1. Identification of the gene for Nance-Horan syndrome (NHS). (PMID: 15466011) Brooks SP … Hardcastle AJ (Journal of medical genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for NHSL1 Gene

Sources for NHSL1 Gene

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