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Aliases for NHLRC4 Gene

Aliases for NHLRC4 Gene

  • NHL Repeat Containing 4 2 3 5

External Ids for NHLRC4 Gene

Previous GeneCards Identifiers for NHLRC4 Gene

  • GC16P000558
  • GC16P000612
  • GC16P000614

Summaries for NHLRC4 Gene

GeneCards Summary for NHLRC4 Gene

NHLRC4 (NHL Repeat Containing 4) is a Protein Coding gene. An important paralog of this gene is TRIM32.

Additional gene information for NHLRC4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC4 Gene

Genomics for NHLRC4 Gene

GeneHancer (GH) Regulatory Elements for NHLRC4 Gene

Promoters and enhancers for NHLRC4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I000565 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 556.8 +1.6 1622 5.7 PKNOX1 ARNT ARID4B SIN3A ZNF2 POLR2B ZNF766 ZNF263 SP3 SP5 PIGQ NHLRC4 ENSG00000282907 WFIKKN1 LUC7L ENSG00000269482 WDR90 WDR24 CCDC154 TELO2
GH16I000523 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 -39.2 -39204 7.6 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 CAPN15 LINC00235 GC16M000522 NHLRC4 PRR35 PIGQ ENSG00000261505 ENSG00000260022 AXIN1 ENSG00000260051
GH16I000586 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 +24.1 24137 8.4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 RAB40C GC16M000587 WDR90 ENSG00000261505 ENSG00000260051 WFIKKN1 ENSG00000260954 RHOT2 WASH4P JMJD8
GH16I000456 Enhancer 1.3 FANTOM5 Ensembl ENCODE 14.8 -109.2 -109226 2.3 HDAC1 EGR1 EGR2 USF2 SP1 PRDM6 KLF16 SMARCA4 IKZF1 CEBPA DECR2 NHLRC4 NME4 PRR35 PIGQ ENSG00000230428 RAB11FIP3 GC16P000492
GH16I000533 Enhancer 1.3 Ensembl ENCODE dbSUPER 13 -32.1 -32094 3.2 ELF3 CLOCK SREBF2 ZFP64 ARID4B KLF17 DMAP1 ZNF48 RAD21 RARA MIR5587 CAPN15 PRR35 NHLRC4 PIGQ NME4 DECR2 GC16M000522
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NHLRC4 on UCSC Golden Path with GeneCards custom track

Genomic Locations for NHLRC4 Gene

Genomic Locations for NHLRC4 Gene
chr16:566,995-569,495
(GRCh38/hg38)
Size:
2,501 bases
Orientation:
Plus strand
chr16:616,996-619,495
(GRCh37/hg19)

Genomic View for NHLRC4 Gene

Genes around NHLRC4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHLRC4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHLRC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC4 Gene

Proteins for NHLRC4 Gene

  • Protein details for NHLRC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG21-NHLC4_HUMAN
    Recommended name:
    NHL-repeat-containing protein 4
    Protein Accession:
    P0CG21
    Secondary Accessions:
    • B8ZZ27
    • Q8N233
    • Q96AX3
    • Q96S23

    Protein attributes for NHLRC4 Gene

    Size:
    123 amino acids
    Molecular mass:
    12631 Da
    Quaternary structure:
    No Data Available

neXtProt entry for NHLRC4 Gene

Post-translational modifications for NHLRC4 Gene

No Post-translational modifications

Other Protein References for NHLRC4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NHLRC4 Gene

Domains & Families for NHLRC4 Gene

Gene Families for NHLRC4 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for NHLRC4 Gene

Suggested Antigen Peptide Sequences for NHLRC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NHLRC4: view

No data available for UniProtKB/Swiss-Prot for NHLRC4 Gene

Function for NHLRC4 Gene

Phenotypes From GWAS Catalog for NHLRC4 Gene

Phenotypes for NHLRC4 Gene

GenomeRNAi human phenotypes for NHLRC4:
genes like me logo Genes that share phenotypes with NHLRC4: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NHLRC4 Gene

Localization for NHLRC4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for NHLRC4 Gene

Pathways & Interactions for NHLRC4 Gene

SuperPathways for NHLRC4 Gene

No Data Available

Interacting Proteins for NHLRC4 Gene

Gene Ontology (GO) - Biological Process for NHLRC4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for NHLRC4 Gene

Drugs & Compounds for NHLRC4 Gene

No Compound Related Data Available

Transcripts for NHLRC4 Gene

mRNA/cDNA for NHLRC4 Gene

Unigene Clusters for NHLRC4 Gene

NHL repeat containing 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC4 Gene

No ASD Table

Relevant External Links for NHLRC4 Gene

GeneLoc Exon Structure for
NHLRC4
ECgene alternative splicing isoforms for
NHLRC4

Expression for NHLRC4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NHLRC4 Gene

NURSA nuclear receptor signaling pathways regulating expression of NHLRC4 Gene:

NHLRC4

SOURCE GeneReport for Unigene cluster for NHLRC4 Gene:

Hs.664267
genes like me logo Genes that share expression patterns with NHLRC4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for NHLRC4 Gene

Orthologs for NHLRC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for NHLRC4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC618053 33
  • 80.05 (n)
NHLRC4 34
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nhlrc4 33 16 34
  • 79.67 (n)
dog
(Canis familiaris)
Mammalia NHLRC4 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves NHLRC4 34
  • 23 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NHLRC4 34
  • 31 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101734263 33
  • 57.68 (n)
Species where no ortholog for NHLRC4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for NHLRC4 Gene

ENSEMBL:
Gene Tree for NHLRC4 (if available)
TreeFam:
Gene Tree for NHLRC4 (if available)

Paralogs for NHLRC4 Gene

Paralogs for NHLRC4 Gene

genes like me logo Genes that share paralogs with NHLRC4: view

Variants for NHLRC4 Gene

Sequence variations from dbSNP and Humsavar for NHLRC4 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000990691 -- 566,300(+) G/T upstream_transcript_variant
rs1001419601 -- 566,922(+) C/T upstream_transcript_variant
rs1001772200 -- 566,748(+) G/A upstream_transcript_variant
rs1002368237 -- 565,852(+) C/T upstream_transcript_variant
rs1002422093 -- 566,060(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for NHLRC4 Gene

Variant ID Type Subtype PubMed ID
nsv952898 CNV deletion 24416366
nsv833114 CNV gain+loss 17160897
nsv833113 CNV loss 17160897
nsv571006 CNV gain 21841781
nsv570988 CNV gain 21841781
nsv528354 CNV loss 19592680
nsv526903 CNV loss 19592680
nsv471064 CNV gain 18288195
nsv471063 CNV loss 18288195
nsv457304 CNV gain 19166990
nsv1160325 CNV duplication 26073780
esv2422427 CNV duplication 17116639
dgv4823n54 CNV loss 21841781

Variation tolerance for NHLRC4 Gene

Residual Variation Intolerance Score: 59.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NHLRC4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NHLRC4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHLRC4 Gene

Disorders for NHLRC4 Gene

Additional Disease Information for NHLRC4

No disorders were found for NHLRC4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHLRC4 Gene

Publications for NHLRC4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for NHLRC4 Gene

Sources for NHLRC4 Gene

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