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Aliases for NHLRC2 Gene

Aliases for NHLRC2 Gene

  • NHL Repeat Containing 2 2 3 5
  • Novel NHL Repeat Domain Containing Protein 3
  • NHL Repeat-Containing Protein 2 3
  • 1200003G01Rik 3

External Ids for NHLRC2 Gene

Previous GeneCards Identifiers for NHLRC2 Gene

  • GC10P115280
  • GC10P115604
  • GC10P109241

Summaries for NHLRC2 Gene

GeneCards Summary for NHLRC2 Gene

NHLRC2 (NHL Repeat Containing 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+.

Additional gene information for NHLRC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NHLRC2 Gene

Genomics for NHLRC2 Gene

GeneHancer (GH) Regulatory Elements for NHLRC2 Gene

Promoters and enhancers for NHLRC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I113851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 -0.5 -492 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 DCLRE1A NHLRC2 CCDC186 FAM160B1 LOC105378488 TCF7L2 ENSG00000212589
GH10I114365 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.3 +513.0 512969 3.2 ZSCAN4 SIN3A FEZF1 BATF ZSCAN5C ATF7 RCOR1 FOS RUNX3 CEBPB VWA2 NHLRC2 GC10P114357 AFAP1L2
GH10I113891 Enhancer 0.3 ENCODE 0.3 +37.1 37085 0.2 PRDM10 ADRB1 TDRD1 GC10P113911 NHLRC2
GH10I113865 Enhancer 0.2 Ensembl 0.4 +11.5 11508 0.5 ADRB1 NHLRC2 GC10P113911
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NHLRC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NHLRC2 gene promoter:

Genomic Locations for NHLRC2 Gene

Genomic Locations for NHLRC2 Gene
62,563 bases
Plus strand

Genomic View for NHLRC2 Gene

Genes around NHLRC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NHLRC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NHLRC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NHLRC2 Gene

Proteins for NHLRC2 Gene

  • Protein details for NHLRC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    NHL repeat-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8N1H1
    • Q8N5A6

    Protein attributes for NHLRC2 Gene

    726 amino acids
    Molecular mass:
    79444 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05316.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for NHLRC2 Gene


neXtProt entry for NHLRC2 Gene

Post-translational modifications for NHLRC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for NHLRC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NHLRC2 Gene

Domains & Families for NHLRC2 Gene

Gene Families for NHLRC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for NHLRC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NHLRC2: view

No data available for UniProtKB/Swiss-Prot for NHLRC2 Gene

Function for NHLRC2 Gene

Phenotypes From GWAS Catalog for NHLRC2 Gene

Gene Ontology (GO) - Molecular Function for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with NHLRC2: view

Phenotypes for NHLRC2 Gene

genes like me logo Genes that share phenotypes with NHLRC2: view

Animal Models for NHLRC2 Gene

MGI Knock Outs for NHLRC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for NHLRC2

miRNA for NHLRC2 Gene

miRTarBase miRNAs that target NHLRC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NHLRC2 Gene

Localization for NHLRC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NHLRC2 gene
Compartment Confidence
extracellular 4
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0031093 platelet alpha granule lumen TAS --
genes like me logo Genes that share ontologies with NHLRC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for NHLRC2 Gene

Pathways & Interactions for NHLRC2 Gene

genes like me logo Genes that share pathways with NHLRC2: view

Gene Ontology (GO) - Biological Process for NHLRC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0045454 cell redox homeostasis IEA --
genes like me logo Genes that share ontologies with NHLRC2: view

No data available for SIGNOR curated interactions for NHLRC2 Gene

Drugs & Compounds for NHLRC2 Gene

No Compound Related Data Available

Transcripts for NHLRC2 Gene

mRNA/cDNA for NHLRC2 Gene

Unigene Clusters for NHLRC2 Gene

NHL repeat containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NHLRC2 Gene

No ASD Table

Relevant External Links for NHLRC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for NHLRC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NHLRC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for NHLRC2 Gene

This gene is overexpressed in Uterus (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NHLRC2 Gene

Protein tissue co-expression partners for NHLRC2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of NHLRC2 Gene:


SOURCE GeneReport for Unigene cluster for NHLRC2 Gene:


Evidence on tissue expression from TISSUES for NHLRC2 Gene

  • Liver(4.3)
  • Stomach(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with NHLRC2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for NHLRC2 Gene

Orthologs for NHLRC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for NHLRC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia NHLRC2 33 34
  • 99.4 (n)
(Canis familiaris)
Mammalia NHLRC2 33 34
  • 91.41 (n)
(Bos Taurus)
Mammalia NHLRC2 33 34
  • 90.13 (n)
(Mus musculus)
Mammalia Nhlrc2 33 16 34
  • 82.57 (n)
(Rattus norvegicus)
Mammalia Nhlrc2 33
  • 81.15 (n)
(Ornithorhynchus anatinus)
Mammalia NHLRC2 34
  • 80 (a)
(Monodelphis domestica)
Mammalia NHLRC2 34
  • 75 (a)
(Gallus gallus)
Aves NHLRC2 33 34
  • 74.43 (n)
(Anolis carolinensis)
Reptilia NHLRC2 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia nhlrc2 33
  • 64.69 (n)
(Danio rerio)
Actinopterygii nhlrc2 34
  • 60 (a)
NHLRC2 (1 of 2) 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12547 33 34
  • 52.67 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010610 33
  • 49.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G56500 33
  • 50.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.297 34
  • 28 (a)
Species where no ortholog for NHLRC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NHLRC2 Gene

Gene Tree for NHLRC2 (if available)
Gene Tree for NHLRC2 (if available)

Paralogs for NHLRC2 Gene

(1) SIMAP similar genes for NHLRC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with NHLRC2: view

No data available for Paralogs for NHLRC2 Gene

Variants for NHLRC2 Gene

Sequence variations from dbSNP and Humsavar for NHLRC2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000000174 -- 113,867,079(+) A/C intron_variant
rs1000092831 -- 113,906,681(+) T/C intron_variant
rs1000154313 -- 113,885,777(+) C/T intron_variant
rs1000231011 -- 113,911,674(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000276103 -- 113,855,076(+) G/A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NHLRC2 Gene

Variant ID Type Subtype PubMed ID
nsv428238 CNV loss 18775914
nsv517356 CNV gain+loss 19592680
nsv525892 CNV loss 19592680
nsv552201 CNV loss 21841781
nsv7211 OTHER inversion 18451855
nsv831995 CNV gain+loss 17160897

Variation tolerance for NHLRC2 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.80; 86.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NHLRC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NHLRC2 Gene

Disorders for NHLRC2 Gene

Additional Disease Information for NHLRC2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for NHLRC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NHLRC2 Gene

Publications for NHLRC2 Gene

  1. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for NHLRC2 Gene

Sources for NHLRC2 Gene

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