Aliases for NHLH2 Gene
External Ids for NHLH2 Gene
Previous HGNC Symbols for NHLH2 Gene
Previous GeneCards Identifiers for NHLH2 Gene
GeneCards Summary for NHLH2 Gene
NHLH2 (Nescient Helix-Loop-Helix 2) is a Protein Coding gene. Diseases associated with NHLH2 include Neuroblastoma. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and RNA polymerase II activating transcription factor binding. An important paralog of this gene is NHLH1.
UniProtKB/Swiss-Prot Summary for NHLH2 Gene
Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Involved in regulating energy expenditure, body mass, voluntary physical activity, mating behavior and reproductive longevity, acting through the hypothalamic-pituitary-gonadal axis. Acts as a transcriptional activator of target genes, including NDN and PCSK1. May act centrally to regulate function of both white and brown adipose tissue. Together with NHLH1, required to maintain migration and survival of cells in the anterior extramural migration stream (aes), which forms the precerebellar nuclei. Also, in concert with NHLH1, may determine fate of gonadotropin releasing hormone-1 (GnRH-1) neurons.