Aliases for NHLH1 Gene
External Ids for NHLH1 Gene
Previous HGNC Symbols for NHLH1 Gene
Previous GeneCards Identifiers for NHLH1 Gene
The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040).[supplied by OMIM, Nov 2002]
GeneCards Summary for NHLH1 Gene
NHLH1 (Nescient Helix-Loop-Helix 1) is a Protein Coding gene. Diseases associated with NHLH1 include Orofacial Cleft 12 and Orofacial Cleft 11. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and DNA-binding transcription activator activity, RNA polymerase II-specific. An important paralog of this gene is NHLH2.
UniProtKB/Swiss-Prot Summary for NHLH1 Gene
May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system.